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  • 1
    Electronic Resource
    Electronic Resource
    Letter to the editor (1994)
    Oxford, UK : Blackwell Publishing Ltd
    FEMS immunology and medical microbiology 9 (1994), S. 0 
    Details
    ISSN: 1574-695X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1574-695X.1994.tb00491.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of lysophosphatidic acid on motility, polarisation and metabolic burst of human neutrophils (1994)
    Oxford, UK : Blackwell Publishing Ltd
    FEMS immunology and medical microbiology 8 (1994), S. 0 
    Details
    ISSN: 1574-695X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Abstract The effect of lysophosphatidic acid (LPA) on human neutrophil activation was examined by a combination of automated tracking assays, cell shape measurements and assays of the metabolic burst by means of 7-dimethylamino-naphthalene-1,2-dicarbonic acid hydrazide (DNDH)-dependent chemiluminescence. LPA powerfully stimulated polarisation and motility. Polarisation became detectable at 2 μM LPA and virtually 100% of cells were polarised at 20 μM LPA. Cell motility increased with the degree of polarisation, and was diminished at high LPA concentration, but this decrease was reversed by albumin. LPA also inhibited the metabolic burst response to both n-formyl-methionyl-leucyl-phenylalanine (fMLP) and phorbol 12-myristate 13-acetate (PMA). Inhibition of the PMA-induced metabolic burst by LPA was not affected by pertussis toxin, showing that the effect was not mediated by the pertussis toxin-sensitive heterotrimeric G protein, and that inhibition of the PMA-stimulated metabolic burst by LPA could result from a direct action of LPA on the small cytosolic GTP-binding proteins. These results indicate that lysophosphatidic acid production by thrombin-activated platelets could play a significant role in the regulation of the inflammatory response.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1574-695X.1994.tb00452.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Relationship of Human Neutrophil Morphology and Actin Distribution to Dispersive Locomotion caused by a steroid induced factor (1997)
    Springer
    Experimental biology online 2 (1997), S. 1-12 
    Details
    ISSN: 1430-3418
    Keywords: Neutrophils ; Monocyte ; Actin ; Locomotion ; Adhesion ; Glucocorticoids
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract A monocyte-derived steroid-induced factor has been shown previously to induce dispersive locomotion in human neutrophils and to lower adhesion to an albumin-coated glass surface. In this paper we show that this factor inhibits adhesion of neutrophils to bovine aorta and human endothelial cells by an undetermined mechanism. It induces unique changes in neutrophil shape with a characteristic monopolar pattern of F-actin distribution, which may correlate with the dispersive locomotion observed in the absence of a concentration gradient. This factor also inhibits N-formyl-methionyl-leucyl-phenylalanine-induced chemotaxis of neutrophils in a modified Boyden chamber assay. The reduction of adhesion and the inhibition of chemotaxis by the factor in vitro indicate a possible in vivo anti-inflammatory role.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s00898-997-0007-6
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    Paper (German National Licenses)
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