ISSN:
1744-313X
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Biology
,
Medicine
Notes:
HLA phenotypes were studied in 59 Chinese myasthenia gravis (MG) patients. Unfractionated peripheral blood mononuclear cells were used for typing of HLA-A, B and C, and B-enriched lymphocytes for HLA-DR. Seventy-nine healthy subjects were included as controls. When compared with healthy controls, the patients showed significant increases in HLA-Bw46 (47·5% versus 14%, χ2= 18·7, P 〈 0·001), HLA-DRw9 (59·3% versus 11%, χ2= 35·7, P 〈 0.001), while HLA-DR3 was decreased (3·4% versus 32·9%, χ2= 18·2, P 〈 0.001). Further analysis showed that the primary association was with DRw9 and the increase in Bw46 was secondary to it. Both HLA-Bw46 and -DRw9 were increased in all subgroups except where the age of onset was greater than 40 years. Finally, the HLA-A2-Bw46-DRw9 combination was also significantly increased in patients (25.4% versus 5.1%, χ2= 11.5, P 〈 0.001), especially in the subgroups of MG with age of onset of less than 10 and males with age of onset of less than 40 years.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1744-313X.1987.tb00382.x
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