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  • 1
    Electronic Resource
    Electronic Resource
    Differential regulation by Ca2+ of calmodulin- and PKC-dependent contractile pathways in cat lower oesophageal sphincter (2003)
    Oxford, UK : Blackwell Science Ltd
    Autonomic & autacoid pharmacology 23 (2003), S. 0 
    Details
    ISSN: 1474-8673
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Chemistry and Pharmacology , Medicine
    Notes: 1 In the present investigation we examined the regulation of calmodulin (CaM)- and protein kinase C (PKC)-dependent pathways by cytosolic Ca2+ in the contraction of cat lower oesophageal sphincter (LES). 2 Force developed in response to increasing doses of acetylcholine (ACh) was directly related to the increase of the [Ca2+]i measured by fura-2. Thapsigargin, which depletes Ca2+ stores, reduced the contraction and the [Ca2+]i. In addition, contraction in response to maximal ACh was reduced by the CaM inhibitor CGS9343B but not by the PKC inhibitor chelerythrine. The contraction in response to submaximal ACh was reduced by chelerythrine but not by CGS9343B. 3 In permeabilized cells, the contraction in response to low Ca2+ (0.54 μm) was also reduced by CGS9343B. 4 The response to high Ca2+ (1.0 μm) was reduced by CGS9343B. ACh also inhibited PKC activation induced by diacylglycerol, which activation is inhibited by the N-myristoylated peptide inhibitor derived from pseudosubstrate sequences of PKCαβγ (myr-PKC-αβγ), but not of myr-PKC-α. 5 These data are consistent with the view that activated CaM-dependent pathways inhibit PKC-dependent pathways, this switch mechanism might be regulated by Ca2+ in the LES.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1474-8673.2004.00302.x
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  • 2
    Electronic Resource
    Electronic Resource
    Focusing of an ultrasonic beam by a curved interface
    Amsterdam : Elsevier
    Wave Motion 12 (1990), S. 497-511 
    Details
    ISSN: 0165-2125
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0165-2125(90)90021-U
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Relationship between heterosis and genetic divergence in ‘Tongil’-type rice (2002)
    Oxford, UK : Blackwell Publishing Ltd
    Plant breeding 121 (2002), S. 0 
    Details
    ISSN: 1439-0523
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Improving grain yield and quality of ‘Tongil’-type rice (indica/japonica) continues to be a major breeding objective in Korea. In this study, genetic divergence among 13‘Tongil’-type rice cultivars was evaluated and the relationship between genetic distance and hybrid performance in all possible nonreciprocal crosses between them assessed. The 78 F1 hybrids together with the 13 parents were evaluated for eight traits of agronomic importance, including yield, in a replicated field trial. The 13 parents were examined for DNA polymorphism using 71 micro-satellite or simple sequence repeats and 46 random decamer oligonucleotide primers. A total of 319 polymorphic variants were generated and, based on the polymorphism data, genetic distances (GDs) ranged from 0.021 to 0.437. Cluster analysis based on GDs revealed associations among cultivars which was in agreement with the pedigree data. Heterosis was observed in hybrids for most of the traits, and yield exhibited the highest heterosis among the eight traits examined. The correlation values of GDs with F1 performance were mostly nonsignificant, except for yield, culm length and spikelets per panicle. The correlations of GDs with midparent and better-parent heterosis were not significant enough to be of predictive value. These results indicate that GDs based on the microsatellite and random amplified polymorphic DNA (RAPD) markers may not be useful for predicting heterotic combinations in ‘Tongil’-type rice and support the idea that the level of correlation between hybrid performance and genetic divergence is dependent on the germplasm used.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1439-0523.2002.00760.x
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  • 4
    Electronic Resource
    Electronic Resource
    FINITE ELEMENT ANALYSIS OF CLOSURE BEHAVIOUR OF FATIGUE CRACKS IN RESIDUAL STRESS FIELDS (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Fatigue & fracture of engineering materials & structures 18 (1995), S. 0 
    Details
    ISSN: 1460-2695
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: An elastic-plastic finite element analysis with high order elements is performed to examine closure behaviour of fatigue. cracks in residua1 stress fieids and the numerical results are then compared with experimental results. The finite element analysis, performed under plane stress using 8-node isoparametric elements, can predict fatigue crack closure behaviour through residual stress fields very well. The crack opening and closing behaviour through a compressive residual stress field is found to be complicated and influenced by the applied load magnitude and the location of the crack tip. Three different types of crack opening behaviour, namely, normal, unsymmetric partial and symmetric partial crack opening behaviour are observed through a compressive residual stress field. The partial crack opening stress intensity factor including the partial crack opening effect is recommended for the prediction of fatigue crack growth through a compressive residual stress field.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1460-2695.1995.tb00145.x
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  • 5
    Electronic Resource
    Electronic Resource
    Macrocrack interaction with transverse array of microcracks (1988)
    Springer
    International journal of fracture 36 (1988), S. 15-26 
    Details
    ISSN: 1573-2673
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Description / Table of Contents: Résumé On envisage une formulation générale du problème d'une microfissure se propageant dans une zone où préexistent des microfissures. On se base, pour ce faire, sur une solution simultanée à un système d'intégrales singulières. Diverses méthodes décrites dans la littérature sont passées en revue de manière détaillée, et comparées à l'approche adoptée. Le problème spécifique considéré est celui d'une macrofissure s'approchant d'un “banc” de microfissures transversales, et les résultats sont applicables à l'interprétation des mécanismes de renforcement de la ténacité en présence de microfissures. Ces résultats illustrent les effets différents qui peuvent avoir les types de mise en charge sur le comportement de matériaux comportant des distributions de microfissures transversales ou des empilements de microfissures. La comparaison des résultats numériques avec les données récemment publiées fait apparaitre l'importance de l'exactitude du schéma numérique adopté. En se comparant à certaines données publiées [6], les résultats obtenus se révèlent divergents dans certains cas.
    Notes: Abstract General formulation of a problem involving a macrocrack propagating through an area with microcracks is considered. The applied approach is based on the simultaneous solution of a system of singular integral equations. Several methods described in the literature are discussed in detail and compared with our approach. The specific problem considered represents a macrocrack approaching an infinite transverse array of microcracks. Results can be used for interpretation of the microcrack-toughening mechanisms. Results illustrate the different effects due to loading types in materials with transverse microcrack arrays (stacks of microcracks). Numerical results are compared with data recently appearing in literature and they demonstrate the importance of the accuracy of the numerical scheme employed. Our results differ by a factor in certain cases as compared with data given in [6].
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00034814
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