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  • 1
    Electronic Resource
    Electronic Resource
    A comparison of neuropsychological deficits in primary and secondary progressive multiple sclerosis (2000)
    Springer
    Journal of neurology 247 (2000), S. 97-101 
    Details
    ISSN: 1432-1459
    Keywords: Key words Multiple sclerosis ; Neuropsychological ; Cognitive ; Magnetic resonance imaging ; Lesion load
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Neuropsychological deficits and the relationship to brain pathology were examined in 13 primary progressive (PP) and 12 secondary progressive (SP) multiple sclerosis patients with a similar duration of the progressive phase and comparable physical disability. A battery of neuropsychological tests to assess attention, short-term and working memory was administered to the patients, and their performance was compared to that of 20 healthy controls matched for age and premorbid IQ. Total cerebral lesion load on T2-weighted magnetic resonance imaging was measured in the patients. Both PP and SP patients performed significantly worse than controls in most of the neuropsychological tests. There were only subtle differences between SP and PP on the working memory task although magnetic resonance imaging lesion load was significantly higher in SP than in PP patients. In this exploratory study only subtle differences in cognitive impairment were detected between SP and PP patients matched for physical disability and relevant illness features. The results also suggest that the severity of cognitive impairment cannot be fully explained by the extent of abnormalities detected on conventional T2-weighted magnetic resonance images, and that other pathological abnormalities such as in normal-appearing white matter are likely to be involved.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00007804
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Alternative (Pd,Ti,Au) contacts to (Pt,Ti,Au) contacts for In0.53Ga0.47As (1998)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 84 (1998), S. 2977-2979 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: (Pd,Ti,Au) contacts, Ti/Pd/Au and Pd/Ti/Pd/Au, to In0.53Ga0.47As have been investigated for applications in InP-based devices. A thin interfacial Pd layer, with an optimum thickness of ∼100 Å, was found to be essential in contact to p+-In0.53Ga0.47As but undesirable to n+-In0.53Ga0.47As. Pd (100 Å)/Ti (200 Å)/Pd (200 Å)/Au (2000 Å) and Ti (200 Å)/Pd (200 Å)/Au (2000 Å) yielded, respectively, a minimum specific contact resistance (ρc) of 1.68×10−6 Ω cm2 and 2.54×10−7 Ω cm2 to p+- and n+-In0.53Ga0.47As(p+=n+=1×1019 cm−3). (Pd,Ti,Au) contacts have shown to outperform (Ti,Pt,Au) counterparts in ρc. In addition, it has been seen that contact anneal beyond 400 °C should be avoided for thin base InP-based heterojunction bipolar transistors. © 1998 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.368449
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Comparative immunogenicity of 146S, 75S and 12S particles of foot-and-mouth disease virus (1982)
    Springer
    Archives of virology 73 (1982), S. 185-191 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Vaccines prepared from 75S particles of FMDV, strain A Cruzeiro, although less potent than 146S particle vaccines, conferred immunity to challenge. Heat and acid degraded 75S particles also conferred significant levels of immunity, whereas degraded 146S particle vaccines were ineffective.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01314726
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Spatial data analysis in the quantitative assessment of cerebral white matter pathology on MRI in HIV infection (1995)
    Springer
    Neuroradiology 37 (1995), S. 429-433 
    Details
    ISSN: 1432-1920
    Keywords: Key words Magnetic resonance imaging ; Spatial autocorrelation ; Cerebral HIV disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This study was carried out using MRI (proton density – and T 2-weighted) on 16 HIV-negative controls, 9 symptom-free HIV-positive patients and 25 with CDC IV HIV disease. The studies from this last group had previously been allocated by a radiologist to the following categories: 8 with focal mass lesions and normal-appearing white matter; 9 with diffuse encephalopathy (high signal on T 2-weighted images, affecting most or all of the white matter) and 8 with patchy encephalopathy (high signal affecting only one or two areas within the white matter). Moran's I, a statistic of spatial autocorrelation, was calculated for the grey-scale values of a sampled pixel array from a central white matter region of each of the images. All values of Moran's I calculated in this study showed a large positive excess over the expected value under randomisation, indicating highly significant positive autocorrelation in the spatial arrangement of the grey-scale values. On T 2-weighted images a statistically significant increase in the mean value of Moran's I, compared with controls, was found in the diffuse encephalopathy group, indicating that quantifiable changes in the spatial autocorrelation of pixel data can be related to recognised qualitative changes in the appearance of white matter in subjects with HIV disease. A lesser, but significant, rise in the mean value of Moran's I was also found in the focal mass lesion group, suggesting that changes in spatial autocorrelation may indicate pathological change in advance of qualitative MRI changes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00600081
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Spatial data analysis in the quantitative assessment of cerebral white matter pathology on MRI in HIV infection (1995)
    Springer
    Neuroradiology 37 (1995), S. 429-433 
    Details
    ISSN: 1432-1920
    Keywords: Magnetic resonance imaging ; Spatial autocorrelation ; Cerebral HIV disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This study was carried out using MRI (proton density-and T2-weighted) on 16 HIV-negative controls, 9 symptom-free HIV-positive patients and 25 with CDC IV HIV disease. The studies from this last group had previously been allocated by a radiologist to the following categories: 8 with focal mass lesions and normal-appearing white matter; 9 with diffuse encephalopathy (high signal on T2-weighted images, affecting most or all of the white matter) and 8 with patchy encephalopathy (high signal affecting only one or two areas within the white matter). Moran'sI, a statistic of spatial autocorrelation, was calculated for the grey-scale values of a sampled pixel array from a central white matter region of each of the images. All values of Moran'sI calculated in this study showed a large positive excess over the expected value under randomisation, indicating highly significant positive autocorrelation in the spatial arrangement of the grey-scale values. On T2-weighted images a statistically significant increase in the mean value of Moran'sI, compared with controls, was found in the diffuse encephalopathy group, indicating that quantifiable changes in the spatial autocorrelation of pixel data can be related to recognised qualitative changes in the appearance of white matter in subjects with HIV disease. A lesser, but significant, rise in the mean value of Moran'sI was also found in the focal mass lesion group, suggesting that changes in spatial autocorrelation may indicate pathological change in advance of qualitative MRI changes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00600081
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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