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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Parasitology research 75 (1988), S. 83-87 
    ISSN: 1432-1955
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Echinostoma population regulation in the experimental rodent host is governed by the capacity of the latter to express an effective regulatory response. Parasite establishment, survival and fecundity are affected by host-related factors such as species, strain and age and by parasite-related factors such as species, age and the burden of infection. The genetic heterogeneity in the regulatory response to infection is marked. The most intensively studied host/echinostome combinations compriseE. caproni andE. trivolvis in the mouse host, for which a range of interesting host-parasite relationships has been demonstrated, including concomitant immunity with rapid expulsion of superimposed infections, a long-lasting resistance to secondary infection, a negatively dose-dependent pattern of expulsion of primary infections, a positively dose-dependent reproductive potential, an infective-dose independency of primary worm establishment, and a range of heterologous antagonistic and synergistic interactions in concurrent infections with related and unrelated parasite species. TheEchinostoma/rodent model is highly suitable for studying aspects of parasite population regulation in intestinal trematode infections.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1955
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Hooded-Lister rats were inoculated with 6, 25, 50 or 100 metacercariae of the intestinal trematodeEchinostoma caproni. Worm establishment and the pattern of egg excretion were followed during the course of primary infections with 6, 25 and 50 metacercariae. Peripheral blood eosinophilia was followed at all infecton levels. After 1 month, worm recovery and faecal egg output showed a gradual decline with increasing duration of infection. High worm burdens were expelled later than smaller worm burdens, and egg output persited longer in animals exhibiting a high initial egg out-put. The level of blood eosinophilia increased with increasing degree of infection and with the level of egg output. A marked concomitant resistance to superimposed infection was observed on the challenge of rats harbouring 21- and 49-day-old infections with 50 metacercariae. In addition, rats were partially resistant to secondary infection at challenge day 14 following anthelmintic removal of primary 7-day-old infections with 50 metacercariae and were completely resistant at challenge day 7 following elimination of a primary 14-day-old primary infection.
    Type of Medium: Electronic Resource
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