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  • 1
    Electronic Resource
    Electronic Resource
    Sequence-specific bifunctional DNA ligands based on triple-helix-forming oligonucleotides inhibit restriction enzyme cleavage under physiological conditions (1991)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 113 (1991), S. 1457-1458 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja00004a081
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Allelic association between a Ser-9-Gly polymorphism in the dopamine D3 receptor gene and schizophrenia (1996)
    Springer
    Human genetics 〈Berlin〉 97 (1996), S. 714-719 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract We examined a Ser-9-Gly polymorphism in the dopamine D3 receptor gene for allelic association with schizophrenia in 133 patients currently treated with clozapine and 109 controls. Allele 1 (Ser-9) was significantly more frequent in the patients (69%) than in the controls (56%) (P = 0.004). The 1-1 genotype was more common (43% vs 30%) and the 2-2 genotype less common (5% vs 18%) in patients than in controls. When the patient group was subdivided on the basis of clinical response to clozapine, using a 20-point improvement in the global assessment scale as cut-off, genotype 1-1 was found to be more frequent among the non-responders (53% vs 36%, P = 0.04). To place our results in the context of previous studies of this polymorphism and schizophrenia, we performed a meta-analysis of all published data including the present sample. The combined analysis shows evidence for a modest association between genotype 1-1 and schizophrenia (odds ratio 1.25, 95% confidence interval 1.05– 1.49, P = 0.01). These results suggest that the Ser-9 allele, or a nearby polymorphism in linkage disequilibrium, results in a small increase in susceptibility to schizophrenia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004390050125
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Genetic mapping of 14 short tandem repeat polymorphisms on human chromosome 22 (1994)
    Springer
    Human genetics 〈Berlin〉 93 (1994), S. 688-690 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract We have constructed a linkage map of 14 short tandem repeat polymorphisms (11 with heterozygosity 〉 70%) on the long arm of human chromosome 22 using 23 non-CEPH pedigrees. Twelve of the markers could be positioned uniquely with a likelihood of at least 1,000:1, and distributed at an average distance of 6.62 cM (range 1.5–16.1 cM). The sex-combined map covers a total of 79.6 cM, the female map 93.2 cM and the male map 64.6 cM. Based on comparisons between physical maps and other genetic maps, we estimate that our map covers 70%–80% of the chromosome. The map integrates markers from previous genetic maps and uniquely positions one marker (D22S307). Data from physical mapping on the location of four genetic markers correlates well with our linkage map, and provides information on an additional marker (D22S315). This map will facilitate high resolution mapping of additional polymorphic loci and disease genes on chromosome 22, and act as a reference for building and verifying physical maps.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00201571
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  • 4
    Electronic Resource
    Electronic Resource
    A service positioning matrix (1998)
    Bingley : Emerald
    International journal of operations & production management 18 (1998), S. 1223-1244 
    Details
    ISSN: 0144-3577
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Economics
    Notes: The service positioning matrix shows how the desired nature of the customer's service encounter activity sequence translates into a recommended service system design. The matrix helps managers think about marketing and operations linkages, roles of the customer and service-provider in creating and delivering services, facility design and process choice, and the different types of management challenges at each position in the matrix. Concepts such as the service encounter activity sequence and the degree of repeatability in the activity sequence are defined and used in the matrix. Examples are given to illustrate the positioning of service entities within the matrix. An empirical evaluation provides statistical support for the logic of the service positioning matrix. The criteria used in the matrix are meaningful to survey participants. Future research directions and issues are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1108/01443579810236647
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  • 5
    Electronic Resource
    Electronic Resource
    An empirical comparison of service matrices (2000)
    Bingley : Emerald
    International journal of operations & production management 20 (2000), S. 705-729 
    Details
    ISSN: 0144-3577
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Economics
    Notes: This research is the first study to evaluate and compare alternative service positioning matrices using rigorous statistical analysis and a common data set based on a variety of service processes. The matrices are evaluated based on five guidelines: clarity of construct definitions, conceptual independence of the two axes of each matrix, clarity in specifying the direction of causation from one axis to the other, axis unidimensionality, and correlation between the two axes of each matrix. These five guidelines provide a more rigorous approach to evaluating current and future positioning matrices, and contribute to the literature by defining more specifically than past research what constitutes a good positioning matrix. The difference between a classification scheme and a positioning matrix are also explained. The results indicate that while there is a statistically significant level of association (correlation) between the axes (Guideline 5) of each of the service matrices studied, meeting the requirements of the other four guidelines is a challenge for some service matrices.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1108/01443570010321685
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    The role of technology and quality on hospital financial performance: An exploratory analysis (2000)
    Bingley : Emerald
    International journal of service industry management 11 (2000), S. 202-224 
    Details
    ISSN: 0956-4233
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Economics
    Notes: The stimulus for this research is that as US hospitals and health care organizations become more competitive, wise investments in technology and quality improvement are keys to financial success and survival. A structural equation model is hypothesized using the following five constructs: clinical technology; information technology; clinical quality; process quality; and hospital financial performance. No research to date has examined the relationships between the type of technology, the type of quality, and hospital financial performance. The general research hypothesis tested is that hospital technology directly drives (affects) quality and hospital financial performance. The results indicate that the type of hospital technology (clinical or information) drives different types of quality-related performance (clinical or process), and directly and indirectly affects hospital financial performance. The simple recursive model documented here is an important first step to defining more complete models that accurately predict hospital financial performance as a function of technology and quality investments and initiatives. The article concludes by summarizing results, discussing their implications, and proposing future research ideas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1108/09564230010340715
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  • 7
    Electronic Resource
    Electronic Resource
    Modelling the relationships between process quality errors and overall service process performance (1995)
    Bingley : Emerald
    International journal of service industry management 6 (1995), S. 4-19 
    Details
    ISSN: 0956-4233
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Economics
    Notes: Describes research which continues the quest to model performanceusing structural equation models. The objective is to provide meaningfuland substantively interpretable predictions of process performance usingstructural equation modelling. Develops structural equation models whichclearly define the performance relationships for a backroom bank cardremittance process using criteria such as process quality errors,employee turnover rates, labour productivity, on-time delivery, and unitcost. Also defines the idea of a process quality equilibrium point(error rate) using structural equation modelling, and investigates howto use these structural equation models to help set internal andexternal standards of performance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1108/09564239510096876
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    Paper (German National Licenses)
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  • 8
    Electronic Resource
    Electronic Resource
    A Service Quality Process Map for Credit Card Processing (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Decision sciences 22 (1991), S. 0 
    Details
    ISSN: 1540-5915
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Economics
    Notes: Evaluating marketing (external) and operations (internal) service quality performance in most organizations is a data-oriented management task that involves many variables for many different types of services. These two diverse sets of service quality information seldom “match up well” because the marketing and operations functions define and evaluate service quality “their way.” Management's interpretation of what the data “mean” often contributes to extra meetings, unnecessary disagreements within and between functional areas, and poor decision making. This situation can affect the quality and timing of decisions, and ultimately, the organization's profitability and market share.This paper quantitatively relates the customer's evaluation (perception) of service quality directly to the activities and performance criteria of the service delivery process for a credit card processing center. Basic statistical analyses and a recursive path analysis model define the relationships between marketing- and operations-based service quality information. The idea of a “service quality process map” is introduced. A service quality process map relates a flowchart of the service delivery process to the customer's perception of service using the power of multivariate data analysis. Management insights gained from an analysis of marketing (external) and operations (internal) measures of service quality performance can be used to allocate resources wisely. The objective is to gain the most improvement in the customer's perception of service for the least cost. Service quality with this type of evaluation capability can be used to gain competitive advantage in the marketplace.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1540-5915.1991.tb00355.x
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  • 9
    Electronic Resource
    Electronic Resource
    THE MEASUREMENT AND OPERATING BENEFITS OF COMPONENT PART COMMONALITY (1981)
    Oxford, UK : Blackwell Publishing Ltd
    Decision sciences 12 (1981), S. 0 
    Details
    ISSN: 1540-5915
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Economics
    Notes: The product structure is a key input to a material requirements planning system. Yet, the effect of alternate product structure designs on system performance is not well understood. Analytical measures are needed to accurately relate product-structure characteristics to total cost and delivery performance.A new analytical measure of product structure called the degree of commonality index is defined in this paper. The degree of commonality index can be applied to single end items, product families, entire product lines, or to any level of product structure.This study suggests that component part commonality, as measured by the degree of commonality index, has a significant effect on system performance. For example, company standardization programs that increase the degree of component part commonality result in manufacturing cost reductions. The degree of commonality index provides a way to directly relate the degree of component part commonality to various dependent variables such as total cost, work center load, and delivery performance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1540-5915.1981.tb00063.x
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    Paper (German National Licenses)
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  • 10
    Electronic Resource
    Electronic Resource
    The Role of Clinical and Process Quality in Achieving Patient Satisfaction in Hospitals (2004)
    J. Mack Robinson College of Business, Georgia State University , Atlanta , GA 30303 , 404-651-4073, fax: 404-651-2804 : Decision Sciences
    Decision sciences 35 (2004), S. 0 
    Details
    ISSN: 1540-5915
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Economics
    Notes: Managers constantly struggle with where to allocate their resources and efforts in managing the complex service delivery system called a hospital. In the broadest sense, their decisions and actions focus on two important aspects of health care—clinical or technical medical care that emphasizes “what” the patient receives and process performance that emphasizes “how” health care services are delivered to patients. Here, we investigate the role of leadership, clinical quality, and process quality on patient satisfaction. A causal model is hypothesized and evaluated using structural equation modeling for a sample of 202 U.S. hospitals. Statistical results support the idea that leadership is a good exogenous construct and that clinical and process quality are good intermediate outcomes in determining patient satisfaction. Statistical results also suggest that hospital leadership has more influence on process quality than on clinical quality, which is predominantly the doctors' domain. Other results are discussed, such as that hospital managers must be mindful of the fact that process quality is at least as important as clinical quality in predicting patient satisfaction. The article concludes by proposing areas for future research.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0011-7315.2004.02570.x
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    Paper (German National Licenses)
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