ISSN:
1612-1112
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Summary A general procedure is presented for predicting the minimum analysis time required to achieve a given chromatographic separation. By combining equations relating the residence time, resolution, and gas flow characteristics of a column, a direct computational procedure is evolved for determining the minimising values of: the inlet to outlet pressure ratio, the column length and the linear gas velocity. This technique is then utilised to discuss the relative sensitivity of the solution to the values of the terms α, β, C g , C L , and D and hence to determine their optimal settings with respect to the characteristic properties of the system. In particular, the feasibility of fast analyses (〈6 sec) within the accessible limits of these parameters is explored, together with a quantitative assessment of the influence of the liquid loading, carrier-gas type and support particle size. The condition when permeability requirements demand a compromise between these factors is identified in terms of the expected flowrate restrictions.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02281017
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