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  • 1
    Electronic Resource
    Electronic Resource
    Anterior thoracic corpectomy without sternotomy: A strategy for malignant disease of the upper thoracic spine (1997)
    Springer
    Acta neurochirurgica 139 (1997), S. 712-718 
    Details
    ISSN: 0942-0940
    Keywords: Metastatic tumor ; thoracic spine ; sternotomy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Background With increasing frequency, spine surgeons are being asked to provide decompression and stabilization in patients with spinal metastases. While no region of the spine is easily treated, the upper thoracic spine is perhaps the least accessible. Traditional approaches to this region involve either thoracotomy or at least limited sternotomy. The authors present an approach to anterior pathology of the upper thoracic spine that obviates the need for sternotomy. Methods Within the past two years, two patients with cervicothoracic metastases underwent anterior decompression and fusion without sternotomy. In both patients, the bodies of C7, T1, and T2 were removed. While both patients were prepared and draped for sternotomy, each required a neck dissection only. In both patients, left-sided incisions were made along the leading edge of the sternocleidomastoid. The platysma was divided with the overlying skin. With further dissection, the strap muscles were tagged and divided approximately one centimeter above their sternal attachments. The loose areolar tissue of the superior mediastinum was then bluntly dissected. Along the entire length of the incision, the vascular plane medial to the carotid sheath was developed to facilitate exposure of the anterior spine. A Farley-Thompson retractor system was then employed to retract and protect the superior mediastinal structures. With this exposure, corpectomies were carried out using a high speed drill. Fusion was accomplished through insertion of Steinmann pins into the adjacent intact bodies above and below. This was followed by application of methyl methacrylate. Both patients had immediate postoperative stability with preservation of spinal cord function. Both patients subsequently underwent removal of dorsally located tumor with posterior fusion. Conclusions The goal of cancer surgery is to provide for increased functional survival without undue morbidity. The authors feel that when possible, the pain of sternal and clavicular osteotomies should be avoided. The described approach works well in conjunction with a methyl methacrylate/Steinmann pin construct. Because of the intact sternum, the surgeon has a downward angle to access the superior endplate of T3. With adequate soft tissue dissection and retraction as described, however, T3 and perhaps even T4 are easily accessible. While this downward angle would likely not permit an anterior plating procedure, it lends itself nicely to Steinmann pin/methyl methacrylate fusion and spares the patient the pain and potential morbidity of sternotomy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01420043
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Acute disseminated encephalomyelitis (ADEM) or ADEM-like inflammatory changes in a heart-lung transplant recipient: a case report (1995)
    Springer
    Neuroradiology 37 (1995), S. 434-437 
    Details
    ISSN: 1432-1920
    Keywords: Acute disseminated encephalomyelitis ; Transplantation ; Magnetic resonance imaging ; FK-506 ; Rabbit antithymocyte globulin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Acute disseminated encephalomyelitis (ADEM) is a white matter inflammatory disease which usually follows a viral infection or pharmaceutical intervention. We describe a case of presumed ADEM in a heart/lung transplant patient, the etiology of which cannot be elucidated. The fascinating aspect is the mode of clinical presentation and the rapid resolution of radiologic abnormalities. Histologic examination of the brain is provided in an attempt to elucidate the radiographic abnormalities.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00600082
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Acute disseminated encephalomyelitis (ADEM) or ADEM-like inflammatory changes in a heart-lung transplant recipient: a case report (1995)
    Springer
    Neuroradiology 37 (1995), S. 434-437 
    Details
    ISSN: 1432-1920
    Keywords: Key words Acute disseminated encephalomyelitis ; Transplantation ; Magnetic resonance imaging ; FK-506 ; Rabbit antithymocyte globulin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Acute disseminated encephalomyelitis (ADEM) is a white matter inflammatory disease which usually follows a viral infection or pharmaceutical intervention. We describe a case of presumed ADEM in a heart/lung transplant patient, the etiology of which cannot be elucidated. The fascinating aspect is the mode of clinical presentation and the rapid resolution of radiologic abnormalities. Histologic examination of the brain is provided in an attempt to elucidate the radiographic abnormalities.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00600082
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    PCR-based typing of DNA extracted from cigarette butts (1991)
    Springer
    International journal of legal medicine 104 (1991), S. 229-233 
    Details
    ISSN: 1437-1596
    Keywords: Cigarette butts ; Saliva ; DNA ; Polymerase chain reaction (PCR) ; HLA-DQ alpha ; D1S80 (pMCT118) ; AMP-FLP ; human identification ; Zigaretten ; Speichel ; DNS ; Polymerase chain reaction (PCR) ; HLA-DQ alpha ; D 1S80 (pMCT118) ; AMP-FLP ; Identifikation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Description / Table of Contents: Zusammenfassung In Anbetracht der limitierten Möglichkeiten der Typisierung von Speichelspuren mittels konventioneller serologischer Methoden wurden fÜr diesen Anwendungsbereich DNA-Typisierungsmethoden, die auf der Polymerase-Chain-Reaction (PCR) basieren, untersucht. Aus 200 Zigaretten, die von 10 verschiedenen Personen geraucht worden waren (20 Zigaretten pro Person), sowie aus 3 von 2 Tatorten stammenden Zigarettenkippen wurde DNA mittels Chelex 100 Methode isoliert und die Menge humaner DNA im Slot-Blot Verfahren bestimmt. Aus den 200 Zigarettenkippen konnten zwischen 〈 2 -160 ng DNA extrahiert werden, aus den von den Tatorten stammenden Zigaretten 8 ng, 50 ng, bzw. 100 ng DNA. Die DNA wurde mittels PCR erfolgreich amplifiziert und typisiert (99 von 100 Zigarettenkippen am HLA-DQ alpha Locus; 99 von 100 Zigarettenkippen am VNTR locus D1S80; sämtliche Zigarettenkippen von den Tatorten). Die Resultate lassen den Schluß zu, daß die DNA-Typisierung mittels PCR eine mögliche Methode zur Analyse von Speichelspuren an
    Notes: Summary Limited genetic marker information can be obtained from saliva by typing by conventional serological means. Thus, the application of PCR-based DNA typing methods was investigated as a potential approach for typing genetic markers in saliva. DNA was isolated from 200 cigarettes smoked by 10 different individuals (20 cigarettes per individual) and from 3 cigarette butts recovered from 2 crime scenes (adjudicated cases) using a Chelex 100 extraction procedure. The amount of recovered human DNA was quantified by slot-blot analysis and ranged from approximately 〈 2-160 ng DNA per cigarette butt for the 200 samples, and 8 ng, 50 ng, and 100 ng for the cigarette butts from the adjudicated cases. The DNA was successfully amplified by the polymerase chain reaction (PCR) for the HLA-DQ alpha locus (99 out of 100 samples) as well as for the variable number of tandem repeat (VNTR) locus D1S80 (99 out of 100 samples). Amplification and typing of DNA was successful on all samples recovered from the crime scenes. The results suggest that PCR-based typing of DNA offers a potential method for genetically characterizing traces of saliva on cigarette butts.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01369812
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    Paper (German National Licenses)
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