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  • 1
    Electronic Resource
    Electronic Resource
    Modification of glycosylated haemoglobin concentration during artificial endocrine pancreas treatment of diabetics (1980)
    Springer
    Diabetologia 18 (1980), S. 125-130 
    Details
    ISSN: 1432-0428
    Keywords: Glycosylated haemoglobin ; artificial endocrine pancreas ; continuous blood glucose monitoring ; subcutaneous insulin treatment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In order to verify whether or not insulininduced blood glucose control can acutely lower glycosylated haemoglobin levels, HbAI (a+b+c) (HbAI) was measured in 11 diabetics before, during and after 3 days of treatment with an “artificial endocrine pancreas” (Biostator). Initially 5 patients were in fair glycaemic control (group A), while the other 6 showed poor control (group B). HbAI levels decreased significantly after 3 days in both groups A (from 9.6 ± 0.2% to 8.5 ± 0.3%, mean ± SEM, p 〈 0.05) and B (from 13.7 ± 0.2% to 12.6 ± 0.3%, p 〈 0.05). A further HbAI decrease was observed until day 60 following Biostator treatment, during which period glycaemic control inproved, as assessed by fasting and post-lunch plasma glucose values and daily glycosuria determined every 10 days. These results suggest that increased HbAI levels may be reversed early by strict blood glucose control during a 3 day period. It is concluded that HbAI levels not only reflect long-term glycaemic control, but also recent acute variations in mean blood glucose values.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00290488
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Lack of glucagon response in glucose counter-regulation in Type 1 (insulin-dependent) diabetics: Absence of recovery after prolonged optimal insulin therapy (1982)
    Springer
    Diabetologia 22 (1982), S. 100-105 
    Details
    ISSN: 1432-0428
    Keywords: Catecholamines ; cortisol ; glucagon ; glucose counter-regulation ; growth hormone ; hypoglycaemia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Mild hypoglycaemia was induced using an artificial pancreas in five normal subjects (from 5.00 ±0.15 to 2.83±0.15 mmol/l) by infusing 28 mU/m2 per min soluble insulin for 60 min. Six Type 1 (insulin-dependent) diabetic patients were stabilized for 14h using an artificial pancreas. They were then rendered hypoglycaemic (from 4.94±0.09 to 2.89±0.11 mmol/l) by infusing 28mU/m2 per min plus 16 ±3.8mU/min insulin for 60 min. Before the study, the diabetic patients were in optimal blood glucose control (mean blood glucose 6.72±0.11 mmol/l over the previous 14–20 days; HbA1 8.3±0.1%). During the insulin infusion test, blood glucose decrement was slower in the diabetic patients than in the control subjects. The blood glucose nadir was delayed in the diabetics until 75 min compared with 55 min in the control subjects. Blood glucose recovery rate in the diabetic subjects was severely impaired. In Type 1 diabetes, the counter-regulatory hormonal response to insulin induced hypoglycaemia is similar to that of non-diabetics, except for that of glucagon, the blunted response of which is not reversed by prolonged optimisation of blood glucose control. This impaired response of the A cell does not seem to be a consequence of insulin deficiency.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00254837
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Genotypic identification of sequentialCandida albicans isolates from AIDS patients by polymerase chain reaction techniques (1997)
    Springer
    European journal of clinical microbiology & infectious diseases 16 (1997), S. 601-605 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Random amplification of polymorphic DNA and inter-repeat polymerase chain reaction (IR-PCR) were compared with restriction fragment length polymorphism (RFLP) analysis as methods for DNA typing ofCandida albicans. Forty-seven strains ofCandida albicans isolated from the oral cavities of five AIDS patients undergoing fluconazole therapy were analyzed. There was an excellent correspondence between the DNA types obtained by both PCR-based techniques and by RFLP. With the exception of one patient who was infected with three DNA types ofCandida albicans during a five-year observation period, the patients each harboured only one major strain, which became progressively less susceptible to fluconazole. Each DNA type was unique to a patient. The data suggest that these typing methods are suitable for investigating the epidemiology of oropharyngeal candidiasis in this patient group.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02447925
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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