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  • 1
    Electronic Resource
    Electronic Resource
    Study of the Pictet-Spengler Reaction in Aprotic Media: Synthesis of the β-Galactosidase Inhibitor, Pyridinolol. (1979)
    s.l. : American Chemical Society
    The @journal of organic chemistry 44 (1979), S. 3740-3740 
    Details
    ISSN: 1520-6904
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jo01335a608
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Congenital diaphragmatic hernia: lung compliance after antenatal tracheal obstruction or surgical correction of the defect (1996)
    Springer
    Pediatric surgery international 11 (1996), S. 524-527 
    Details
    ISSN: 1437-9813
    Keywords: Diaphragmatic hernia ; Compliance ; Plug Fetal surgery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Fetal lambs with diaphragmatic herniae (CDH) created surgically at 73 days' gestation were subjected to three different forms of intrauterine correction: silastic patch correction of the diaphragmatic defect plus an abdominal patch at 101 days gestation; an intrathoracic “silo” at 101 days; and a tracheal “plug” obstruction at 101 or 129 days. At 143 days' gestation (term 145–149 days), the lambs were delivered by caesarean section and ventilated for 30 min before undergoing respiratory compliance measurements. These results were compared to those of normal lambs and animals with uncorrected herniae. The total respiratory system compliance values in those groups undergoing corrections were remarkably similar: those with any form of correction had a significant improvement (P 〈 0.05) compared to those with herniae and no correction (patch = 1.57 = ± 0.182 ml/cm H2O; silo = 1.53 ± 0.179; plug at 101 days = 1.66 ± 0.311; plug at 129 days = 2.00 ± 0,175; without correction = 0.62 ± 0.073). None, however, reached the values of those with normal lungs: 2.72 ± 0.223 (P 〈 0.05). This improvement in compliance in all corrected groups suggests that fetal tracheal obstruction is as effective as the two more invasive forms of open fetal surgery carried out in this study and, as this procedure lends itself to surgery through a small uterine incision or “minimally invasive” surgery, it may be the procedure of choice to reduce the incidence of preterm labour for those human fetuses undergoing antenatal correction of a CDH.bb
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00626057
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Altered intestinal development after jejunal ligation in fetal sheep (1993)
    Springer
    Virchows Archiv 423 (1993), S. 45-50 
    Details
    ISSN: 1432-2307
    Keywords: Fetus ; Small intestine ; Ultrastructure ; Intestinal atresia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Experimental obstruction of the fetal small intestine resulted in massive hypertrophy of the segment proximal to the site of obstruction. Villus morphology was grossly abnormal. Enterocytes developed many irregular features, most notably cytoplasmic extensions (pseudopods, or blebs) from their apical surface. Distal to the site of obstruction, morphological anomalies which resembled those seen after experimental oesophageal ligation were found. These included delayed disappearance of the apical endocytic network, disrupted or absent microvilli, glycogen accumulation and inappropriate cell extrusion. Proximal to the obstruction, where stasis of swallowed fluid occurs, distension and abnormal intestinal development ensues. Distal to the obstruction where the intestine develops in the absence of swallowed fluid, development is also abnormal. The anomalies resemble those noted after oesophageal ligation in utero, and possibly are the results of reduced cellular nutrition. These results suggest that fetal ingestion provides the developing gastrointestinal tract with an important stimulus for normal growth.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01606431
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  • 4
    Electronic Resource
    Electronic Resource
    A biomechanical analysis of the vertebral and rib deformities in structural scoliosis (1999)
    Springer
    European spine journal 8 (1999), S. 252-260 
    Details
    ISSN: 1432-0932
    Keywords: Key words Scoliosis ; Scoliosis ; deformity ; Scoliosis ; vertebra ; Scoliosis ; rib ; Scoliosis ; biomechanics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Although the structural changes occurring in the scoliotic spine have been reported as early as the 19th century, the descriptions and biomechanical explanations have not always been complete and consistent. In this study, three-dimensionally rendered CT images of two human skeletons with a scoliotic deformity and two patients with serious scoliosis were used to describe the intrinsic vertebral and rib deformities. The pattern of structural deformities was found to be consistent. Apart from the wedge deformation of the apical vertebrae, a rotation deformity was found in the transversal plane between the vertebral body and the posterior complex: the vertebral body was maximally rotated towards the convexity of the scoliotic curve, whereas the tip of the spinous process was pointed to posterior. The rib deformities at the convex side of the scoliotic curve showed an increased angulation of the rib at the posterior angle, whereas the rib curve on the concave side was flattened. The observed vertebral deformities suggest that these are caused by bone remodelling processes due to forces in the anterior spinal column, which drive the apical vertebral body out of the midline, whereas forces of the musculo-ligamentous structures at the posterior side of the spinal column attempt to minimize the deviations and rotations of the vertebrae. The demonstrated rib deformities suggest an adaptation to forces imposed by the scoliotic spine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s005860050169
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  • 5
    Electronic Resource
    Electronic Resource
    Hand prosthesis with adaptive internally powered fingers (1971)
    Springer
    Medical & biological engineering & computing 9 (1971), S. 33-36 
    Details
    ISSN: 1741-0444
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Description / Table of Contents: Sommaire Une nouvelle prothèse de la main, actionnée pneumatiquement, complètement adaptable, a été développée. Les doigts étant actionnés intérieurement, aucun volume additionnel n'est nécessaire et la prothèse peut être adapté à des patients qui ont perdu leurs doigts mais qui possèdent encore la paume de leur main. Autrescaractéristiques sont: une bonne préhension, un poids réduit et une grande vitesse d'opération. Une description de la construction est donnée et le rendement mesuré est discuté.
    Abstract: Zusammenfassung Es wurde eine neue, pneumatisch betriebene, vollständig adaptive Handprothese entwickelt. Da die Finger von innen betrieben werden, ist kein zusätzliches Volumen notwendig und die Prothese kann Patienten angepasst werden, die zwar ihre Finger verloren haben, aber noch ihre Handfläche besitzen. Weitere Merkmale sind: guter Griff, geringes Gewicht und grosse Leistungsgeschwindigkeit. Es wird eine Konstruktionsbeschreibung gegeben und die bemessene Leistungsfähigkeit besprochen.
    Notes: Abstract A new pneumatic powered, completely adaptive, hand prosthesis has been developed. Because of the internal powering of the fingers no additional volume is necessary and the prosthesis can be adapted to patients who have lost their fingers but still possess the palm of their hand. Other features are good prehension, low weight and high operating speed. A description of the construction is given, and the measured performance is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02474402
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    Paper (German National Licenses)
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