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  • 1
    Digitale Medien
    Digitale Medien
    s.l. : American Chemical Society
    Biochemistry 14 (1975), S. 4245-4251 
    ISSN: 1520-4995
    Quelle: ACS Legacy Archives
    Thema: Biologie , Chemie und Pharmazie
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    ISSN: 1520-4995
    Quelle: ACS Legacy Archives
    Thema: Biologie , Chemie und Pharmazie
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 33 (1979), S. 0 
    ISSN: 1471-4159
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 4
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 69 (1997), S. 0 
    ISSN: 1471-4159
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Abstract: Activation of the classical complement pathway has been widely investigated in recent years as a potential mechanism for the neuronal loss and neuritic dystrophy characteristic of Alzheimer's disease (AD) pathogenesis. We have previously shown that amyloid β peptide (Aβ) is a potent activator of complement, and recent evidence suggesting that the assembly state of Aβ is crucial to the progress of the disease prompted efforts to determine whether the ability of Aβ to activate the classical complement pathway is a function of the aggregation state of the peptide. In this report, we show that the fibrillar aggregation state of Aβ, as determined by thioflavin T fluorometry, electron microscopy, and staining with Congo red and thioflavine S, is precisely correlated with the ability of the peptide to induce the formation of activated fragments of the complement proteins C4 and C3. These results suggest that the classical complement pathway provides a mechanism whereby complement-dependent processes may contribute to neuronal injury in the proximity of fibrillar but not diffuse Aβ deposits in the AD brain.
    Materialart: Digitale Medien
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  • 5
    Digitale Medien
    Digitale Medien
    Cambridge : Cambridge University Press
    The @classical quarterly 16 (1966), S. 65-69 
    ISSN: 0009-8388
    Quelle: Cambridge Journals Digital Archives
    Thema: Klassische Philologie, Byzantinistik, Mittellateinische und Neugriechische Philologie, Neulatein
    Notizen: Plato in his discussion of the Divided Line (Republic 6) introduces a distinction between knowledge of the Forms in and by themselves ([...]) and [...]. The first distinguishing characteristic of [...] is that it ‘is compelled to employ assumptions, while knowledge of the Forms tries to advance to a certain first principle’ (510 b 4–9). The second distinguishing characteristic of [...] is that it employs the ordinary objects of sense-perception as images (510 d 5–511 a 1). The geometer, in order to find out about ‘the Square’ and ‘the Diagonal’, draws diagrams and makes models.
    Materialart: Digitale Medien
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  • 6
    Digitale Medien
    Digitale Medien
    Cambridge : Cambridge University Press
    Philosophy 69 (1994), S. 459-469 
    ISSN: 0031-8191
    Quelle: Cambridge Journals Digital Archives
    Thema: Philosophie
    Notizen: An old Arab proverb runs as follows:He who knows not, and knows not that he knows not, is a fool; shun him.He who knows not, and knows that he knows not, is a child; teach him.He who knows, and knows not that he knows, is asleep; wake him.But he who knows, and knows that he knows, is a sage; follow him.
    Materialart: Digitale Medien
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  • 7
    Digitale Medien
    Digitale Medien
    Cambridge : Cambridge University Press
    Philosophy 69 (1994), S. 112-114 
    ISSN: 0031-8191
    Quelle: Cambridge Journals Digital Archives
    Thema: Philosophie
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 8
    Digitale Medien
    Digitale Medien
    Cambridge : Cambridge University Press
    Philosophy 63 (1988), S. 401-402 
    ISSN: 0031-8191
    Quelle: Cambridge Journals Digital Archives
    Thema: Philosophie
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 9
    Digitale Medien
    Digitale Medien
    Cambridge : Cambridge University Press
    Philosophy 66 (1991), S. 169-175 
    ISSN: 0031-8191
    Quelle: Cambridge Journals Digital Archives
    Thema: Philosophie
    Notizen: Any account of knowledge has to take account both of the contribution of the world and the contribution of man. Every human endeavour, every activity, every art, every science is a product of a unique interaction between man and the world. Where man is most passive, he merely reflects and reports the world; this is pure discovery, if it ever exists. Where man is most active, the world's contribution lies merely in the provision of the raw material; this is pure invention, if it ever exists. All the arts, all the sciences can be ordered in a continuous array or spectrum ranging from pure discovery to pure invention. That they are all at some point on this continuum gives them a common but fragile thread, justifying our thinking and talking of the unity of the arts and sciences. Philosophy is neither pure discovery nor pure invention; it bears resemblances to both a science and an art. In this paper I propose to try to give reasons why we should regard the philosopher as an artist and philosophy as an art; or, at any rate, I shall try to show that there is an Art of Philosophy.
    Materialart: Digitale Medien
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  • 10
    Digitale Medien
    Digitale Medien
    Cambridge : Cambridge University Press
    Philosophy 41 (1966), S. 19-33 
    ISSN: 0031-8191
    Quelle: Cambridge Journals Digital Archives
    Thema: Philosophie
    Notizen: It is a surprising fact that moral philosophers have rarely examined the distinction between what I shall call ‘positive’ or ‘social’ morality on the one hand and ‘autonomous’ or ‘individual’ morality on the other. Accordingly, conceptual and moral issues of the greatest importance have been neglected. The distinction is, I take it, recognised by Hegel, when he contrasts Sittlichkeit with Moralität. However, the rival sides who give a conceptual or a moral preference to one concept over the other rarely come to grips with one another, and the deep conflicts between them are concealed instead of being brought out into the open. Only in Burke's diatribe against Rousseau, Bradley's critique of Sidgwick (Collected Essays I, 122), Hobhouse's crusade against Bosanquet (Metaphysical Theory of the State), Prichard's attack on Green (Moral Obligation, p. 75), Hart's criticism of Hare (‘Legal and Moral Obligation’ in Essays in Moral Philosophy, edited by Melden), and above all in Oakeshott's onslaught on Rationalism (Rationalism in Politics, passim) do we get a glimpse of one of the main issues of moral philosophy and of morality. For just as we have two concepts, so we have two moral conceptual schemes, each of which gives a central place to one concept at the expense of the other. Those who suppose that morality is or ought to be wholly or mainly a social concept may recommend submission to a tradition. Those, on the other hand, who suppose morality to be primarily an individual or independent concept will recommend independent decisions. I want in this paper, firstly, to explain the differences between the two concepts, secondly, to show that neither of them is conceptually illegitimate or degenerate, and lastly, to determine what place, if any, each ought to have in a rational morality.
    Materialart: Digitale Medien
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