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  • 1
    ISSN: 1432-1041
    Keywords: Calcium antagonists ; Amlodipine ; hypertension ; renal function
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary In this study the efficacy and safety of short-term amlodipine administration on renal haemodynamics were evaluated in mild to moderate hypertensive subjects. Our final goal was to evaluate whether the reduced blood pressure induced by treatment was associated with maintenance of renal function. After a run-in period with placebo, 30 hypertensive patients without cardiac or renal diseases were randomly allocated to a double-blind 4 weeks controlled study with amlodipine 10 mg once a day (15 patients) or placebo (15 patients). Renal haemodynamic measurements included effective renal plasma flow (ERPF) and glomerular filtration rate (GFR) by radionuclide study using 131I-hippuran and 99mTc, with methods described by Schlegel and Gates, respectively. In addition, effective renal blood flow [ERBF=ERPF/(1-Ht)], filtration fraction (FF=GFR/ERPF) ERPF) and renal vascular resistance (RVR=MBP×80/ERBF) were calculated. Plasma renin activity (PRA), serum aldosterone (ALD) and urinary excretion of sodium (NaU) were evaluated. At the end of amlodipine administration a significant decrease (P〈0.001) in SBP, DBP and MBP from baseline values was observed. A significant decrease (P〈0.01) in RVR and significant increases (P〈0.05) in ERPF, ERBF and in NaU were also found, without relevant changes in GFR, FF, PRA and ALD. No significant variation in clinical and renal measurements was observed in the placebo group. No relevant side effects were observed in either group. In conclusion, amlodipine was effective in lowering blood pressure in mild to moderate hypertension and exerted favourable effects on renal haemodynamics and function.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1041
    Keywords: arrhythmia ; hypertension ; LVH ; holter monitoring ; BP monitoring
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary To evaluate the relationship among supraventricular and ventricular arrhythmias with blood pressure and heart rate (HR) values, we studied 2 groups of 20 hypertensive men with (group I) and without (group II) left ventricular hypertrophy. Ambulatory electrocardiographic tracings were recorded continuously, together with ambulatory arterial pressure. Systolic (SBP) and diastolic (DBP) blood pressure values measured over 24 h showed no difference between the two groups, but we found greater variability in SBP in group I. The incidence of ventricular and supraventricular arrhythmias was significantly higher in patients of group I; moreover, we found a strong correlation between the incidence of ventricular extrasystoles (VPCs) and SBP, DBP, and HR values in group I, whereas in group 11 the incidence of supraventricular extrasystoles (APCs) was higher during peaks of SBP and HR values. The relationship between APCs and SBP observed in group II may be attributable to the pressure stimulus on a normal atrium, and the significant correlation between VPCs and SBP, DBP, and HR values may be due to episodes of subendocardial ischemia or to the influence of adrenergic stimulation on previously compromised myocardial tissue.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1573-3025
    Keywords: Aerobiology ; Epidemiology ; Olea europaéa ; Aerobiologia ; Epidemiologia ; Olea europaéa
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Description / Table of Contents: Riassunto Sono stati effettuati tre anni (1984–86) di osservazioni epidemiologiche ed aerobiologiche per ricercare la relazione esistente tra concentrazione pollinica giornaliera delle Oleacee nell' atmosfera della città di Palermo e numero di casi di pollinosi dovute a tale polline. I dati aerobiologici sono stati ottenuti con un campionatore volumetrico VPPS 2000. Questi, elaborati con il metodo della media mobile su 7 giorni e correlati con i dati epidemiologici, hanno evidenziato che, nel nostro territorio, le famiglie di pollini che rivestono importanza clinica sono tre: Urticacee, prevalentemente Parietaria, Graminacee ed Oleacee, prevalentemente Olea europaéa. Le Oleacee occupano il terzo posto nel determinismo delle pollinosi (21,76% di tutte le pollinosi), mentre dal punto di vista aerobiologico sono al secondo posto. La mancanza di proporzionalità diretta è da mettere in relazione, verosimilmente, con il breve periodo sintomatologico e con un basso potere allergizzante di tale aeroallergene. E' stato registrato, negli ultimi dieci anni, anche in Sicilia, un aumento della frequenza di sensibilizzazione verso il polline delle Oleacee.
    Notes: Summary Three years of epidemiological and aerobiological observations (1984–86) were carried out in order to search the existing relationship between the Oleacee's daily pollen concentration in Palermo's atmosphere and the number of hay fever cases due to such pollen. The aerobiological data were abtained with a 2000 VPPS volumetric sampler. These data, elaborated by a seven day moving average method and correlated woth epidemiological data, evidenced that three of the pollen families in our territory are clinically important: Urticacee, prevailing Parietaria, Graminacee and Oleacee, prevailing Olea europaéa. The Oleacee, occupy the third position in hay fever determinism (21,76% of all hay fever), while on the aerobiological point of view they occupy the second position. The lack of direct proportionality is probabily related with the short sintomatological period and the low allergic potentiality of the aeroallergene. It has been registered, in the last ten years, even in Sicily, an increase of the frequency of sensitization towards Oleacee pollen.
    Type of Medium: Electronic Resource
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