ISSN:
1013-9826
Source:
Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
Topics:
Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
Notes:
Previous in vitro studies confirmed an improved cytocompatibility of chitosan-silicatehybrid membranes over chitosan membranes. The main goal of this study was to assess the in vivohistocompatibility of both membranes through subcutaneous implantations at different time periods,1 week, 1, 2 and 3 months, using a sheep model. Chitosan membranes elicited an exuberantinflammatory response and were consequently rejected. The hybrid chitosan membranes were notrejected and the degree of inflammatory response decreased gradually until the third month ofimplantation. Histological evaluation also showed that these membranes can be resorbed in vivo.This study demonstrates that the incorporation of silicate into the chitosan solution improves itshistocompatibility, indicating that the hybrid chitosan-silicate membranes are suitable candidates tobe used in clinical applications
Type of Medium:
Electronic Resource
URL:
http://www.tib-hannover.de/fulltexts/2011/0528/01/56/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.361-363.1265.pdf
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