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  • 1
    Electronic Resource
    Electronic Resource
    New aspects of the microstructure of polyethylene-isotactic polypropylene gel blends as revealed by microhardness: influence of composition (1990)
    s.l. : American Chemical Society
    Macromolecules 23 (1990), S. 5352-5355 
    Details
    ISSN: 1520-5835
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ma00228a008
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  • 2
    Electronic Resource
    Electronic Resource
    Novel aspects in the structure of poly(ethylene terephthalate) as revealed by means of small angle x-ray scattering (1991)
    s.l. : American Chemical Society
    Macromolecules 24 (1991), S. 5980-5990 
    Details
    ISSN: 1520-5835
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ma00022a013
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  • 3
    Electronic Resource
    Electronic Resource
    LCST Behavior in Polymer Blends (1977)
    s.l. : American Chemical Society
    Macromolecules 10 (1977), S. 681-686 
    Details
    ISSN: 1520-5835
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ma60057a037
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  • 4
    Electronic Resource
    Electronic Resource
    The Basis for Miscibility in Polyester-Polycarbonate Blends (1979)
    s.l. : American Chemical Society
    Macromolecules 12 (1979), S. 726-731 
    Details
    ISSN: 1520-5835
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ma60070a038
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  • 5
    Electronic Resource
    Electronic Resource
    Traumatic interhemispheric subdural haematomas (1991)
    Springer
    Acta neurochirurgica 111 (1991), S. 128-131 
    Details
    ISSN: 0942-0940
    Keywords: Subdural haematoma ; interhemispheric ; head injury ; computed tomography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary According to reports in the literature traumatic interhemispheric subdural haematomas (I.S.H.) are supposed to present acutely or subacutely with contralateral monoparesis of a lower extremity or hemiparesis or in bilateral haematomas even with paraparesis, and to need early operative evacuation. In our series of 5 cases none of them followed this “classical” clinical picture, and three of them recovered without operation. We conclude that the indication for operative evacuation depends on the clinical course and that in patients with spontaneously improving symptomatology non-surgical management under close supervision may be the better solution. Also the C.T. finding of open convexity cisterns may be possible indication for conservative management.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01400500
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  • 6
    Electronic Resource
    Electronic Resource
    Long-term effect of nonsteroidal anti-inflammatory drugs on the production of cytokines and other inflammatory mediators by blood cells of patients with osteoarthritis (1994)
    Springer
    Inflammation research 41 (1994), S. 171-178 
    Details
    ISSN: 1420-908X
    Keywords: NSAIDs ; osteoarthritis ; cytokines ; lipid mediators
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Most of the previous studies dealing with the effect of nonsteroidal anti-inflammatory drugs (NSAIDs) on the synthesis of inflammatory mediators involved in joint damage have been done in cells culturedin vitro or in blood cells from patients treated for short periods of time. In this work we have evaluated the long-term effect of aceclofenac, a new NSAID, and diclofenac on the production of a series of inflammatory mediators by blood cells from 30 patients with severe knee osteoarthritis. Both aceclofenac and diclofenac significantly inhibited prostaglandin E2 (PGE2) synthesis by blood mononuclear and polymorphonuclear cells after 180 days of treatment. However, no clear effect was noted on leukotriene B4 (LTB4) and platelet activating factor (PAF) production. The generation of O 2 − by polymorphonuclear cells, stimulated with FMLP, was decreased after 15 days of treatment with both drugs, but reached normal values after 180 days. Interleukin-1β (IL-1β) production decreased significantly at 180 days with both drugs in the group of high producer patients. In a few (n=3) patients with high basal mononuclear cell tumor necrosis factor α (TNFα) production, this also decreased on treatment for 180 days with the NSAIDs. In the remaining low TNFα-producing patients, TNFα production tended to increase. Interleukin-6 (IL-6) synthesis was not affected by aceclofenac while it was diminished by diclofenac. The decrease in IL-6 in all treated patients was significantly correlated with a worsening of the clinical condition. On the whole, these data could afford a pathogenetic basic for the long-term employment of these drugs in patients with inflammatory conditions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02001912
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  • 7
    Electronic Resource
    Electronic Resource
    Neurofibrillary changes in the cerebral cortex of a patient with subacute sclerosing panencephalitis (SSPE) (1979)
    Springer
    Acta neuropathologica 48 (1979), S. 157-160 
    Details
    ISSN: 1432-0533
    Keywords: Subacute sclerosing panencephalitis ; Neurofibrillary degeneration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Biopsy fragments from the frontal cortex of one patient with SSPE were studied with ultrastructural methods. Special attention was given to the presence of neurofibrillary tangles observed in all cortical layers. These tangles were composed either of filaments with a diameter of 10–12 nm or of paired helical filaments 22–24 nm at their widest and periodically reduced to 10 nm about every 80 nm. These tangles were observed in all cortical layers, while those formed by single filaments were only visualized in layer 3. The simultaneous appearance of both types of tangles in the same patient suggests that they may be chemically related, which is in keeping with recent chemical data concerning the nature of the neurofilament protein subunit.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00691159
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  • 8
    Electronic Resource
    Electronic Resource
    Characteristics of a wire preionized nitrogen laser with helium as buffer gas (1984)
    Springer
    Applied physics 35 (1984), S. 131-133 
    Details
    ISSN: 1432-0649
    Keywords: 42.55 Hq
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The operation of a small N2 laser using wire preionization and He as a buffer gas is discussed. The preionization is found to increase the output power and energy by 50% while the addition of helium can increase fourfold the output power.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00697701
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  • 9
    Electronic Resource
    Electronic Resource
    Experimental Traumatic Cerebral Contusion: Morphological Study of Brain Microvessels and Characterization of the Oedema (1998)
    Springer
    Acta neurochirurgica 140 (1998), S. 76-81 
    Details
    ISSN: 0942-0940
    Keywords: Keywords: Brain oedema; head injury; blood-brain barrier; morphology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Several experimental brain oedema models are currently available, but most of them are very different from what happens in clinical practice. As it is simple and seems to replicate the range of injuries seen in man we decided to evaluate Marmarou's model of head injury in order to test physiopathogenic and therapeutic hypotheses. Three groups of Wistar rats weighing 360–400 gr, anaesthetized with sodium pentobarbitone and breathing spontaneously, without tracheal intubation, were studied. In the first group six animals were killed two hours after injury and the brain's water content compared with that of nine controls. In another group Evans blue (100 mg/kg) was injected one hour before trauma and dye's extraction ratio determined at various times after injury: five animals at 15 minutes, six at 30 minutes, five at 60 minutes and nine at 120 minutes. A total of twenty-eight animals served as controls. In the last group morphological studies with light and electron microscopy were performed in the traumatized brain tissue from rats killed 5 and 120 minutes after injury and in brain tissue from control rats. Results showed that Marmarou's brain trauma model induced perivascular brain oedema, already visible at the ultrastructural level 5 minutes after the injury. Endothelial cells themselves were “oedematiated”, rich in pinocytotic vesicles and membrane blebs, and presented intact tight junctions. Two hours after trauma the perivascular oedema was more marked. At this time the brain water content was significantly higher than that in controls. Evans blue extraction ratio increased linearly with time, being significantly higher than in controls 120 minutes after injury. We conclude that Marmarou's model is a suitable model for the study of brain oedema induced by trauma, and that this oedema, assessed by three different methodologies, was statistically significant two hours after injury.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007010050061
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  • 10
    Electronic Resource
    Electronic Resource
    Ultrastructural study of brain microvessels in patients with traumatic cerebral contusions (1997)
    Springer
    Acta neurochirurgica 139 (1997), S. 215-220 
    Details
    ISSN: 0942-0940
    Keywords: Blood-brain barrier ; brain oedema ; head trauma ; ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Brain tissue from 11 patients with traumatic cerebral contusions submitted to surgery was studied. Control biopsy specimens were obtained from 5 patients undergoing ventriculo-peritoneal shunts for “communicating” hydrocephalus. After collection, the small fragments were fixed by immersion in glutaraldehyde-osmium and embedded in Epon. Semi-thin sections stained with toluidine blue were observed with the light microscope. Thin sections stained with lead citrate and uranyl acetate were observed using a Jeol electron microscope. In tissues from patients with head trauma a clear space most probably corresponding to fluid accumulation was systematically observed around microvessels. Ultrastructurally endothelial cells from these specimens exhibited signs of marked intracellular oedema, tight junctions being intact. Pinocytotic activity was increased, mainly at the abluminal surface. Swelling of astrocytic perivascular processes and the appearance of macrophagic cells with voluminous lysosomes were also observed. The authors conclude that the oedema of endothelial cells probably represent a central fact in the pathophysiology of traumatic brain oedema and speculate on the putative involvement of stretch-activated receptors in this condition.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01844754
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