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  • 1
    Electronic Resource
    Electronic Resource
    The effects of finite population size and selection on the correlation between gene frequency changes at two different loci and on the amount of linkage disequilibrium (1972)
    Springer
    Theoretical and applied genetics 42 (1972), S. 335-345 
    Details
    ISSN: 1432-2242
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary A potentially infinite random-mating population of monoecious diploid individuals is subjected to a single cycle of sampling and selection based on the values of a quantitative character. In the absence of epistatic interactions, expressions are obtained for the correlation between the gene frequencies at two linked loci and for the mean and variance of linkage disequilibrium after one cycle of selection. Numerical results are presented for a range of population sizes and for various values of the genetic parameters.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00275358
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  • 2
    Electronic Resource
    Electronic Resource
    “Backcasting” with the World Dynamics Models (1973)
    [s.l.] : Nature Publishing Group
    Nature 243 (1973), S. 63-65 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Two members of the Science Policy Research Unit at the University of Sussex discuss whether or not a Systems Dynamics model can meaningfully be run backwards in ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/243063a0
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  • 3
    Electronic Resource
    Electronic Resource
    BSE susceptibility (1990)
    [s.l.] : Nature Publishing Group
    Nature 347 (1990), S. 610-610 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SIR-Our paper on the inheritance of susceptibility to bovine spongiform en-cephalopathy (BSE) in pedigree Holstein Friesian cattle (Veterinary Record 126, 5-8; 1990) is relevant to the question raised by your correspondent O. H. G. Sparrow (Nature 346, 694; 1990) as to whether BSE is gene-linked. ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/347610c0
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  • 4
    Electronic Resource
    Electronic Resource
    A phase I study of a HER2/neu bispecific antibody with granulocyte-colony-stimulating factor in patients with metastatic breast cancer that overexpresses HER2/neu (1999)
    Springer
    Cancer immunology immunotherapy 48 (1999), S. 9-21 
    Details
    ISSN: 1432-0851
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A phase I study of escalating doses of humanized bispecific antibody (bsAb) MDX-H210 with granulocyte-colony-stimulating factor (G-CSF) was conducted in patients with metastatic breast cancer that overexpressed HER2/neu. The main objectives of the study were to define the maximal tolerated dose (MTD) of MDX-H210 when combined with G-CSF, to measure the pharmacokinetics of MDX-H210 when administered with G-CSF, and to determine the toxicity, biological effects and possible therapeutic effect of MDX-H210 with G-CSF. MDX-H210 is a F(ab)′ × F(ab)′ humanized bispecific murine antibody that binds to both HER2/neu and the FcγR1 receptor (CD64), and was administered intravenously weekly for three doses followed by a 2-week break and then three more weekly doses. A total of 23 patients were treated, and doses were escalated from 1 mg/m2 to 40 mg/m2 with no MTD reached. The toxicity of the bsAb + G-CSF combination was modest, with no dose-limiting toxicity noted: 19 patients had fevers, 7 patients had diarrhea, and 3 patients had allergic reactions that did not limit therapy. The β-elimination half-life varied from 4 h to 8 h at doses up to 20 mg/m2. Significant release of cytokines interleukin-6, G-CSF, and tumor necrosis factor α was observed after administration of bsAb. Circulating monocytes disappeared within 1 h of bsAb infusion, which correlated with binding of bsAb, noted by flow-cytometric analysis. Significant levels of human anti-(bispecific antibody) were measured in the plasma of most patients by the third infusion. No objective clinical responses were seen in this group of heavily pre-treated patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002620050543
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  • 5
    Electronic Resource
    Electronic Resource
    Estimating the locations and the sizes of the effects of quantitative trait loci using flanking markers (1992)
    Springer
    Theoretical and applied genetics 85 (1992), S. 480-488 
    Details
    ISSN: 1432-2242
    Keywords: Quantitative trait loci ; Interval mapping ; RFLPS mapping
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The use of information from flanking markers to estimate the position and size of the effect of a quantitative trait locus (QTL) lying between two markers is shown to be affected by QTLs lying in neighbouring regions of the chromosome. In some situations the effects of two QTLs lying outside the flanked region are reinforced in such a way that a ‘ghost’ QTL may be mistakenly identified as a real QTL. These problems are discussed in the framework of a backcross using a regression model as the analytical tool to present the theoretical results. Regression models that use information obtained from three or more nearby markers are shown to be useful in separating the effects of QTLs in neighbouring regions. A simulated data set exemplifies the problem and is analysed by the interval mapping method as well as by the regression model.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00222330
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  • 6
    Electronic Resource
    Electronic Resource
    An accurate approximation to the distribution of the length of the longest matching word between two random DNA sequences (1990)
    Springer
    Bulletin of mathematical biology 52 (1990), S. 773-784 
    Details
    ISSN: 1522-9602
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract An accurate approximation is derived to the distribution of the length of the longest matching word present between two random DNA sequences of finite length, using only elementary probability arguments. The distribution is shown to be consistent with previous asymptotic results for the mean and variance of longest common words. The application of the distribution to assessing the statistical significance of sequence similarities is considered. It is shown how the distribution can be modified to take account of non-independence of neighbouring bases in real sequences.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02460808
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  • 7
    Electronic Resource
    Electronic Resource
    Multiple forms of synthase D phosphatase and phosphorylase a phosphatase in liver and regulatory effects of metabolites on their activities (1985)
    Springer
    Molecular and cellular biochemistry 66 (1985), S. 151-162 
    Details
    ISSN: 1573-4919
    Keywords: cytosol and smooth endoplasmic reticulum ; multiple forms ; synthase phosphatase and phosphorylase phosphatase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Summary The smooth endoplasmic reticulum (ER) and cytosol fractions of liver homogenates exhibit phosphoprotein phosphatase activity towards glycogen synthase D and phosphorylase a. The following observations suggest that liver contains multiple forms of these phosphatases. Synthase phosphatase activity in either fraction was more readily inactivated by heating than phosphorylase phosphatase activity. Both synthase phosphatase and phosphorylase phosphatase activities in smooth ER were non-competitively inhibited by Mg2+, but were activated by this ion in the cytosol. Synthase phosphatase activities in cytosol and smooth ER were stimulated by a number of sugar phosphates, particularly glucose-l-phosphate, galactose-6-phosphate and fructose-6-phosphate. Erythrose-4-phosphate stimulated synthase phosphatase activity in the cytosol, but inhibited the microsomal enzyme. Phosphorylase phosphatase activities in either fraction were inhibited by most sugar phosphates. Adenosine mono-, di- and tri-phosphates inhibited phosphatase activities in both fractions. Low concentrations of AMP and ADP inhibited phosphorylase phosphatase activities to a greater extent than synthase phosphatase activities. Chromatography of the smooth ER fraction on DEAE-cellulose resulted in the separation of synthase phosphatase from phosphorylase phosphatase, as soluble proteins. The elution profile for the microsomal phosphatase was different from that for the cytosol enzymes. It is concluded that: (a) both synthase phosphatase and phosphorylase phosphatase in liver have at least two isoenzyme forms (b) synthase phosphatase and phosphorylase phosphatase are separate enzymes (c) the different behaviour of microsomal and cytosol phosphatases towards divalent cations and sugar phosphates provides a potential mechanism for the differential regulation of these activities in liver.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00220783
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  • 8
    Electronic Resource
    Electronic Resource
    Long term regulation of glycogen metabolizing enzymes by insulin in H4 hepatoma cells (1987)
    Springer
    Molecular and cellular biochemistry 75 (1987), S. 137-149 
    Details
    ISSN: 1573-4919
    Keywords: insulin ; glycogen enzymes ; regulation ; longterm ; hepatoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract Insulin alone at concentrations of less than 1 to 5 uU/ml increased the enzyme activities of glycogen synthase, synthase phosphatase, phosphorylase, and phosphorylase phosphatase in hepatoma H4 cells in culture in the presence and absence of serum. Increase in total and active forms of glycogen synthase and phosphorylase were observed. Cycloheximide blocked the action of insulin on glycogen synthase, glycogen synthase phosphatase and phosphorylase phosphatase. The enzymes with the exception of glycogen synthase phosphatase were expressed with greater hormonal sensitivity in the absence as compared to the presence of serum in terms of hormone concentration required and or time of onset. These results demonstrate that these glycogen metabolizing enzymes are under long term control by insulin, with glycogen synthase being the most sensitive of the enzymes studied to the action of the hormone.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00229902
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  • 9
    Electronic Resource
    Electronic Resource
    Conditioning on the number of bands in interpreting matches of multilocus DNA profiles (1995)
    Springer
    Genetica 96 (1995), S. 51-53 
    Details
    ISSN: 1573-6857
    Keywords: DNA profiling ; number of bands
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01441151
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