ISSN:
1432-0533
Keywords:
Postischemic Hyperemia
;
Intracranial Hypertension
;
Brain Edema
;
No-Reflow
;
Recirculation
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary A no-reflow phenomenon was observed in cats immediately after cerebral ischemia. When ischemia was followed by a normal recirculation of 1 hr duration, only minor perfusion defects and no intracranial hypertension was observed. If, however, ischemia was preceded by moderate hypoxia for several hours, extreme postischemic hyperemia was necessary to prevent the development of intracranial hypertension and a no-reflow phenomenon. Electron microscopic investigation revealed that capillary obstruction did not develop within the first hour after ischemia. Thus the no-reflow is not related to capillary lesions. The results support the view that the no-reflow phenomenon is produced by blood aggregates which obstruct vessels. This phenomenon is to some extent reversible. If, however, a slow-down of blood flow is induced by intracranial hypertension based on postischemic brain edema, the no-reflow is enhanced. There was no indication that arterial hypertension increases brain edema after ischemia.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00684393
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