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  • 1
    ISSN: 1365-2516
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Replacement therapy in patients with severe haemophilia A is associated with the development of inhibitory antibodies in about 15% [1,2]. The presence of inhibitors of factor VIII greatly complicates and compromises the treatment of these patients because of the lack of any completely satisfactory product to treat them. Haemostatic management for surgery in patients with inhibitors is very difficult. A product frequently used to treat bleeding episodes in such patients is prothrombin complex concentrate (PCC) [3] or its activated derivative (APCC) [4]. Activated recombinant human factor VII is another option [5]. For both these modalities of treatment, there are no laboratory tests that can be used to monitor clinical efficacy [5, 6]. Porcine factor VII is therefore the preferred product for surgery in patients with high-responding factor VIII inhibitors [7]. Unfortunately, none of these products are readily available in most developing countries, including India.We report the management of a patient with high-responding factor VIII inhibitor using low doses of FEIBAR (Immuno, Austria) in the post-operative period.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Haemophilia 10 (2004), S. 0 
    ISSN: 1365-2516
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary.  External fixators (EF) are not commonly used for patients with haemophilia. We describe the use of EF (Ilizarov, AO- uni- and bi-planar fixators and Charnley clamp) in nine patients (mean age: 19.2 years; range: 9–37) with haemophilia for the following indications – arthrodesis of infected joints, treatment of open fractures and osteoclasis. EF required an average of nine skin punctures [range: 4–17 were maintained for a period of 15 weeks (range: 8–29.5), without regular factor replacement, till bone healing was adequate and were removed with a single dose of factor infusion]. The mean preoperative factor level achieved was 85% (range: 64–102%). Much lower levels were subsequently maintained till wound healing. The average total factor consumption was 430 IU kg−1 (range: 240–870), administered over a period of 17 days (range: 9–44). There were no major complications related to EF except in a patient who developed inhibitors. In conclusion, EF can be used safely in haemophilic patients who do not have inhibitors and does not require prolonged factor replacement.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Geophysical prospecting 45 (1997), S. 0 
    ISSN: 1365-2478
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences , Physics
    Notes: During recent gravity surveys in Patagonia, we were unable to acquire data on the North Patagonian Icecap, which is completely inaccessible for land surveying. The Icecap is clearly of tectonic significance, but, because of its tectonic history, it is uplifted and rugged, and consequently inaccessible. Therefore the distribution of geophysical observations which can be acquired in a rugged field area is dependent on the tectonic history. This suggests that a tectonic history which is reconstructed from geophysical data may be systematically biased.We use models of local and flexural isostasy to estimate the gravity errors associated with interpolation across inaccessible topography. The gravity error is largest for Pratt isostasy, where the mass deficit which supports the topography is at relatively shallow depths. The gravity error is least for flexural isostasy, because in this case the inaccessible topography is supported regionally by a mass deficit which extends beyond the inaccessible region.An analytical flexural interpolation scheme is proposed for interpolation across data gaps associated with inaccessible topography. Flexural theory and Gauss’s theorem are used to predict the gravity anomaly due to the mass excess of the inaccessible topography. We apply this scheme to the North Patagonian Icecap, to demonstrate that flexural interpolation predicts a relative gravity low at the site of the Icecap, which would not be predicted by purely geometrical interpolation schemes.
    Type of Medium: Electronic Resource
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