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  • 1
    Electronic Resource
    Electronic Resource
    Population Dynamics of CD4+ T Cells Lacking Thy-1 in Murine Retrovirus-Induced Immunodeficiency Syndrome (MAIDS) (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 39 (1994), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Increased numbers of CD4+ Thy-1 cells have been described in the spleen (SP) of mice with retrovirusinduced immunodeliciency (MAIDS). Since this phenotypic abnormality might have considerable functional importance, the expansion of the CD4+ Thy-1 subset in MAIDS was characterized further. CD4+ Thy-1− and Thy-1+ T-cell is from infected mice expressed similar densities of CD3 and TCR γ/β. In contrast, the Thy-I− subset was uniformly CD44hi, even early in the disease when part of Thy-I+ cells were still CD4410. The emergence of CD4+ Thy-1−cells occurred first in SP and lymph nodes and was observed later in thymus. The important fraction ofCD4+ cells lacking Thy-1 normally present in Peyer's patches was only weakly modified. Despite the major expansion of the CD4+ Thy-1− phenotype. the proliferating fraction was not higher in this subset than in CD4+ Thy-1+ cells from infeeted miee. Persistence after hydroxyurea administration was identical in both subsets, indicating similar mean cell lifespans. Taken together, these results show that the major expansion of CD4+ Thy-I− T-cells in MAIDS is not ascribable solely to increased proliferation within this subset. Phenotypic analysis suggests that CD4+ Thy-I− cells result from the differentiation of Thy-I+ cells induced by activation signals related to retroviral infection.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1994.tb03363.x
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  • 2
    Electronic Resource
    Electronic Resource
    Idiopathic hypertrophic cranial pachymeningitis mimicking multiple meningiomas: case report and review of the literature (1997)
    Springer
    Acta neuropathologica 94 (1997), S. 385-389 
    Details
    ISSN: 1432-0533
    Keywords: Key words Dura mater ; Meningitis ; Tumor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A case of idiopathic hypertrophic cranial pachymeningitis with an unusual and misleading manifestation is reported. Computed tomography scan, angiographic and magnetic resonance imaging findings were suggestive of multiple meningeal neoplasms and a correct diagnosis was made only after meningeal biopsy. This 44-year-old patient had a previous history of an ill-defined systemic disorder associating episcleritis, erythroderma nodosa and multiple peripheral arthritis. We review previous reports of idiopathic cranial pachymeningitis with emphasis on radiological investigation techniques, histopathology and possible dysimmune mechanisms of pathogenesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004010050723
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    A new combined Bodian-Luxol technique for staining unmyelinated axons in semithin, resin-embedded peripheral nerves: a comparison with electron microscopy (1999)
    Springer
    Acta neuropathologica 98 (1999), S. 323-329 
    Details
    ISSN: 1432-0533
    Keywords: Key words Unmyelinated fibers ; Peripheral nerve ; Electron microscopy ; Histochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Quantitation of unmyelinated fibers (UF) in peripheral nerves has classically relied upon ultrastructural morphometry. Because this method is time-consuming, it is not typically performed in routine analysis of nerve biopsies. We applied the Bodian-Luxol technique to detect unmyelinated axons by light microscopy on semithin sections from resin-embedded nerve tissue. Estimates were compared to ultrastructural counts. The staining appeared highly specific for axons. Excellent correlation was found between optic densities and the population of UF larger than 0.5 μm. The smallest profiles detected by light microscopy had a diameter close to 0.6 μm. This new technique is not a substitute for ultrastructural quantitative morphometry of UF, as very small unmyelinated axons, especially regenerating ones, can not be reliably visualized. However, it provides a valuable light microscopic method for evaluating axonal loss among UF.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004010051088
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    Paper (German National Licenses)
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