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  • 1
    Electronic Resource
    Electronic Resource
    Substance P Afferents Regulate ACTH-Corticosterone Release (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 632 (1991), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1991.tb33117.x
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  • 2
    Electronic Resource
    Electronic Resource
    Time Course of Capsaicin-Evoked Release of CGRP from Rat Spinal Cord in Vitro (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 657 (1992), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1992.tb22809.x
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  • 3
    Electronic Resource
    Electronic Resource
    Evidence for an Increase in the Release of CGRP from Sensory Nerves during Inflammation (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 657 (1992), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1992.tb22814.x
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  • 4
    Electronic Resource
    Electronic Resource
    Activation of Primary Afferents in the Rabbit Ear by Noxious Heat (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 632 (1991), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1991.tb33124.x
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  • 5
    Electronic Resource
    Electronic Resource
    Human and Rat Primary C-Fibre Afferents Store and Release Secretoneurin, a Novel Neuropeptide (1994)
    Oxford, UK : Blackwell Publishing Ltd
    European journal of neuroscience 6 (1994), S. 0 
    Details
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Secretoneurin is a recently discovered neuropeptide derived from secretogranin II (SgII). Since this peptide could be detected in the dorsal horn of the spinal cord we studied whether it is localized in and released from primary afferent neurons. Secretoneurin was investigated with immunocytochemistry and radioimmunoassay in spinal cord, dorsal root ganglia and peripheral organs. SgII mRNA was determined in dorsal root ganglia. Normal rats and rats pre-treated neonatally with capsaicin to destroy selectively polymodal nociceptive (C-) fibres were used. Slices of dorsal spinal cord were perfused in vitro for release experiments. Immunocytochemistry showed a distinct distribution of secretoneurin-immunoreactivity (IR) in the spinal cord and lower brainstem. A particularly high density of fibres was found in lamina I and outer lamina II of the caudal trigeminal nucleus and of the spinal cord. This distribution was qualitatively identical in rat and human post-mortem tissue. Numerous small diameter and some large dorsal root ganglia neurons were found to contain SgII mRNA. Capsaicin treatment led to a marked depletion of secretoneurin-IR in the substantia gelatinosa, but not in other immunopositive areas of the spinal cord and to a substantial loss of small (〈25 μm) SgII-mRNA-containing dorsal root ganglia neurons. Radioimmunoassay revealed a significant decrease of secretoneurin-IR in the dorsal spinal cord, the trachea, heart and urinary bladder of capsaicin-treated rats. Perfusion of spinal cord slices with capsaicin as well as with 60 mM potassium led to a release of secretoneurin-IR. In conclusion, secretoneurin is a neuropeptide which is stored in and released from capsaicin-sensitive, primary afferent (C-fibre) neurons. It may, therefore, be a novel peptidergic modulator of pain transmission or of C-fibre mediated non-nociceptive information.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1460-9568.1994.tb00996.x
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  • 6
    Electronic Resource
    Electronic Resource
    Effects of carbonyl cyanide p-trichloromethoxyphenylhydrazone (CCCP) and of ruthenium red (RR) on capsaicin-evoked neuropeptide release from peripheral terminals of primary afferent neurones (1990)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 341 (1990), S. 534-537 
    Details
    ISSN: 1432-1912
    Keywords: Capsaicin ; Ruthenium Red ; CCPP ; Afferent neurones
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In the superfused isolated rat urinary bladder, capsaicin as well as electrical field stimulation evoked the release of calcitonin gene-related peptide-like immunoreactivity (CGRP-IR). Carbonyl cyanide p-trichloromethoxyphenylhydrazone (CCCP, threshold 2 μM) reduced both, the capsaicin- and the electrical field stimulation-evoked release of CGRP-IR while a low concentration of Ruthenium Red (RR, 0.6 μM and 2 μM) selectively attenuated the capsaicin-evoked release of CGRP-IR but did not influence the effect of electrical field stimulation. 20 μM RR nearly abolished the capsaicin-evoked release, but also attenuated the effect of electrical field stimulation. In the isolated guinea-pig bronchus, electrical field stimulation and capsaicin induced non-cholinergic contractions which are known to be caused by tachykinin release from afferent nerve terminals. CCCP (0.6 μM) only reduced the response to field stimulation; a ten-fold higher concentration of CCCP attenuated field stimulation as well as capsaicin-induced contractions. This is in contrast to the reported selective inhibition of capsaic-ininduced contractions by RR. The present data demonstrate that CCCP generally inhibits evoked neuropeptide release, regardless of the kind of stimulation used while low concentrations of RR preferentially inhibit capsaicin-evoked neuropeptide release.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00171733
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  • 7
    Electronic Resource
    Electronic Resource
    Reflex fall in blood pressure mediated by capsaicin-sensitive afferent fibers of the rat splanchnic nerve (1983)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 322 (1983), S. 286-289 
    Details
    ISSN: 1432-1912
    Keywords: Capsaicin ; Substance P ; Splanchnic nerve ; Primary afferent neurons ; Adrenal catecholamine release ; Depressor reflex
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. Capsaicin treated rats, in which the function of substance P-containing primary sensory neurons was impaired, were used to investigate the function of afferent fibers within the splanchnic nerve. The effects of electrical stimulation of the splanchnic nerve either distal or proximal to the site of its transsection on blood pressure and heart rate were investigated. 2. Distal splanchnic nerve stimulation evoked an equal rise in blood pressure in capsaicin treated rats and in their controls. Distal splanchnic nerve stimulation did not cause plasma extravasation in the adrenal medulla, an effect which is produced by antidromic stimulation of cutaneous sensory nerves. Peripheral effects of stimulation of primary afferent fibers within the splanchnic nerve cannot be assumed from these experiments. 3. Proximal stimulation of the splanchnic nerve evoked a reflex fall in blood pressure but no bradycardia. The fall in blood pressure was absent in capsaicin treated rats, which indicates that this effect is mediated by primary afferent fibers. Since the reflex fall in blood pressure was abolished by adrenergic blockade with guanethidine, it can be explained by vasodilatation resulting from reduction of sympathetic vasoconstrictor tone.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00508344
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  • 8
    Electronic Resource
    Electronic Resource
    Caerulein, substance P, serotonin, and cholinomimetics induce rhythmic contractions of the intestinal circular muscle (1980)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 312 (1980), S. 131-137 
    Details
    ISSN: 1432-1912
    Keywords: Guinea-pig ileum ; Intestinal circular muscle ; Caerulein ; Substance P ; 5-Hydroxytryptamine ; Cholinomimetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. The mechanical activity of the circular muscle of the isolated guinea-pig ileum in response to various spasmogenic compounds was investigated. Contractions were recorded isotonically. 2. Caerulein (〉0.1 nM), bombesin (〉1 nM), substanceP (〉2 nM), 5-hydroxytryptamine and bethanechol (〉0.5 μM), and dimethylphenylpiperazinium (〉3 μM) induced rhythmic contractions superimposed on an increased tone. 3. Tetrodotoxin (0.93 μM) abolished the actions of caerulein, bombesin, 5-hydroxytryptamine, and dimethylphenylpiperazinium, partially inhibited the effect of substance P, but did not influence the contractile response to bethanechol. 4. The met-enkephalin analogue FK 33-824 (0.17 μM) abolished the action of only those compounds whose action was suppressed by tetrodotoxin, whereas noradrenaline (1.78 μM) blocked the effect of all six spasmogenic compounds studied. 5. An indirect action of caerulein, bombesin, substance P, 5-hydroxytryptamine, or dimethylphenylpiperazinium on the circular muscle by excitation of cholinergic neurones could be excluded because of the ineffectivity of tropicamide (3.64 μM). 6. Experiments employing tachyphylaxis to either substance P or 5-hydroxytryptamine showed that the contractile response to caerulein may involve release of endogenous substance P and that the action of substance P may be mediated via an indoleaminergic pathway. 7. The results imply that excitatory neurotransmitter candidates of the intestine such as cholecystokinin-like peptides (an analogue of which is caerulein), bombesin-like peptides, substance P, 5-hydroxytryptamine, and acetylcholine are able to induce rhythmic, peristalsis-like contractions of the intestinal circular muscle in physiologically relevant concentrations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00569721
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  • 9
    Electronic Resource
    Electronic Resource
    Time course of capsaicin-induced functional impairments in comparison with changes in neuronal substance P content (1981)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 316 (1981), S. 240-243 
    Details
    ISSN: 1432-1912
    Keywords: Substance P ; Capsaicin ; Chronic denervation ; Neurogenic plasma extravasation ; Chemosensitivity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. Changes in the content of substance P (dorsal spinal cord, dorsal roots, dorsal root ganglia, saphenous nerve, skin) and functional changes (neurogenic plasma extravasation, chemosensitivity of the cornea) were measured in the rat from 10 min to 4 days after the s.c. injection of a single dose of 50 mg kg−1 capsaicin. 2. The substance P content in dorsal roots, saphenous nerve and hind paw skin progressively declined to about 60–70% of control 4 days after treatment, whereas that of the dorsal root ganglia rose, after an initial decline, to 140% after 1–4 days. 3. After denervation, impairment of neurogenic plasma extravasation could be observed not earlier than after one day, thus being comparable in time course to the depletion of substance P in the skin and saphenous nerve. 4. Neurogenic plasma extravasation and the chemosensitivity of the cornea were greatly diminished already 10 min after systemic capsaicin treatment, i.e. at a time when the substance P content of the peripheral nerve was still unchanged. These early effects of systemic capsaicin treatment are therefore caused by actions other than depletion of substance P.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00505656
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  • 10
    Electronic Resource
    Electronic Resource
    Analysis of the effects of intravenously injected capsaicin in the rat (1982)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 320 (1982), S. 54-57 
    Details
    ISSN: 1432-1912
    Keywords: Substance P ; Capsaicin ; Primary sensory neurons ; Depressor reflex
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. I.v. injection of 1 or 3 μg capsaicin led to a triphasic blood pressure response in Sprague-Dawley rats but, in contrast to Wistar rats, did not affect heart rate and respiration. The blood pressure response was a sequence of fall (A), return to normal levels or slight rise (B), and fall (C) in blood pressure The blood pressure response to capsaicin remained unchanged after treatment with adrenoceptor or cholinoceptor antagonists. 2. The initial fall in blood pressure (A) was absent after bilateral vagotomy and in the pithed rat. The delayed fall in blood pressure (C) remained unchanged after vagotomy, but was absent after neonatal capsaicin pretreatment and in the pithed rat. Effect B was not diminished after vagotomy or despinalization; it was augmented in rats treated neonatally with capsaicin. 3. I.a. injection of capsaicin into the hind leg caused a reflex fall in blood pressure which was changed to a reflex rise in rats treated with capsaicin as neonates. 4. The initial and the delayed fall in blood pressure after i.v. injection of capsaicin seems to be reflex responses to stimulation of capsaicin-sensitive small diameter afferent fibres. The intermediate rise in blood pressure appears to result mainly from a direct short vasoconstriction by capsaicin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00499072
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