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  • 1
    Electronic Resource
    Electronic Resource
    Interferon modulates glucose-sensitive neurons in the hypothalamus (1997)
    Springer
    Experimental brain research 116 (1997), S. 519-524 
    Details
    ISSN: 1432-1106
    Keywords: Key words Lateral hypothalamus ; Ventromedial hypothalamus ; Interferon ; Glucose ; Single cell ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Interferon-α (IFN) therapy induces feeding suppression that resembles anorexia. The hypothalamic glucose-sensitive neurons engage in feeding behavior. Coronal sections of rat brains, containing both the lateral hypothalamus (LH) and the ventromedial hypothalamus (VMH), as well as single-cell recordings were used to study the interaction between IFN and glucose-sensitive neurons. IFN suppressed the majority (78%) of LH neurons, while reduction in glucose concentration elicited excitation in the majority (85%) of the same neurons. The opposite effects were observed in the VMH, where IFN excited the majority of neurons (61%), and reduction in glucose concentration exerted the opposite effects in 64% of VMH recordings. Concomitant IFN and glucose reduction exhibited only the effects elicited by IFN, regardless of whether the glucose reduction caused excitation (LH) or suppression (VMH). This observation suggests that IFN causes anorexia by modulating the LH and VMH glucose-sensitive neurons.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00005780
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    A direct input from amygdaloid complex to caudate nucleus of the rat (1975)
    Springer
    Experimental brain research 23 (1975), S. 203-210 
    Details
    ISSN: 1432-1106
    Keywords: Caudate ; Spontaneous activity ; Amygdaloid stimulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Spontaneous unit activity was recorded from the caudate nucleus in rats anesthetized with urethane. Amygdaloid nucleus stimulation altered the spontaneous activity of 51 units (65% of the population tested); 23 units (29%) showed an increase and 28 (36%) a decrease of discharge rate. Moreover, 25 units (32%) responded to stimulation with stimulus-locked spikes. Post-stimulus time histograms revealed 7 patterns of response to amygdaloid stimulation. In 4 groups of cells, stimulus-locked spikes occurred followed by alteration of spontaneous discharge rate. In another 2 groups there was a change of spontaneous discharge without stimulus-locked spikes and in the final group no effect occurred. The possibility of mono-, oligo-, and polysynaptic connections from amygdaloid nuclear complex to caudate nucleus was discussed. It was suggested that an amygdalofugal connection to basal ganglia may provide a pathway whereby activity of the limbic system may exert a modulatory influence on somatic motor mechanisms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00235461
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Rat Pineal Exhibits Two Electrophysiological Patterns of Response to Microiontophoretic Norepinephrine Application (1986)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of pineal research 3 (1986), S. 0 
    Details
    ISSN: 1600-079X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The spontaneous activity of 117 pineal units was recorded in urethane-anesthetized rats. The pineal units exhibited a wide range of firing rates of which 50% were on average slower than 14 spikes per second. Superior cervical ganglion (SCG) stimulation was studied in 76 pineal units; this stimulation caused excitation in 55% of the units. Microiontophoretic application of norepinephrine (NE) induced changes of firing rates in 61% of the pineal units tested. Two patterns of activity following NE microiontophoresis was observed: increase in firing rate (64%) and decrease in firing rate (36%). NE-induced excitation was observed only in those units excited by SCG stimulation. When NE and SCG stimulation were applied together, partial summation of the excitation induced by each one alone was observed. None of the units in which NE depressed the firing rate responded to SCG stimulation. Local application of propranolol blocked the excitation initiated by SCG stimulation as well as the excitation and the depression induced by NE microiontophoresis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-079X.1986.tb00744.x
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  • 4
    Electronic Resource
    Electronic Resource
    Photic input to rat pineal gland conveyed by both sympathetic and central afferents (1980)
    Springer
    Journal of neural transmission 48 (1980), S. 203-208 
    Details
    ISSN: 1435-1463
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Average photic evoked responses were recorded from the pineal in light and dark adaptation. Permanent semimicroelectrodes were implanted several days before the experiments were begun. Local anesthesia (xylocaine) at the superior cervical ganglion (scg) level was used as a tool to determine whether or not photic responses are transmitted via the scg and/or through another CNS route. The experiments demonstrated that in dark adaptation, photic evoked responses recorded from the pineal exhibited higher amplitude. Moreover, the photic evoked responses are transmitted via two separate routes: one, a fast pathway with a “shorter” latency, via the CNS,i.e. the habenular posterior commissure complex, and the other a “slower” (or longer) pathway via the reticular formation scg to the pineal.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01243504
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Monoamine effects on neuronal recovery cycles in globus pallidus, caudate nucleus, and substantia nigra (1974)
    Springer
    Journal of neural transmission 35 (1974), S. 275-281 
    Details
    ISSN: 1435-1463
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In freely moving rats, averaged evoked potentials (AAER) to paired click stimuli delivered at varying interstimulus intervals were recorded with semi-microelectrodes simultaneously in globus pallidus (GP), caudate nucleus (CN), and substantia nigra (SN). The effects of intrapentoneal injection of reserpine and L-Dopa on the neuronal recovery cycles were studied. The results indicate that these drugs have different effects in the various structures. The major difference is a lack of effect in SN in contrast to substantial effects in GP and CN. This finding is compatible with the hypothesis that monoamines may be synthesized in SN but exert their major pharmacological action in the GP and CN.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02205224
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Pineal body: Neuronal recording (1975)
    Springer
    Cellular and molecular life sciences 31 (1975), S. 321-322 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Im corpus pineale der Ratte konnte bis zu einer Tiefe von 200 μm spontane Aktivität einzelner neuronaler Elemente nachgewiesen werden. Diese reagierten auf Photostimulation, Stimulation der Habenula und des Fasciculus medialis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01922563
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  • 7
    Electronic Resource
    Electronic Resource
    Gastrointestinal hormones and neural interaction within the central nervous system (1975)
    Springer
    Cellular and molecular life sciences 31 (1975), S. 658-660 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Bei Ratten wurde die Tätigkeit des ZNS mit Hilfe von in diverse Hirnzonen implantierten Elektroden registriert, wobei die sensorische Reizung im Wachzustand zur Aktivierung der elektrischen Aktivität benutzt wurde. Injektionen von Cholecystokinin Oktapeptid in Zonen mit Appetitregulation führte zu systematischer Veränderung der durchschnittlichen Reizbeantwortung.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01944614
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    Paper (German National Licenses)
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