ISSN:
1432-0428
Keywords:
Insulin
;
blood pressure
;
obesity
;
healthy man
;
oral glucose tolerance test
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary In this study, we have measured plasma insulin at fasting and following an oral glucose load and blood pressure after glucose load in 367 (247 non-obese, 120 obese) normotensive and untreated mildly hypertensive subjects. Overall, there was no independent association between fasting plasma insulin levels and blood pressure values. After controlling for age and body weight, a significant relationship between postglucose plasma insulin levels and diastolic blood pressure was found. When non-obese and obese subjects were examined separately, significant relationships were identified between postglucose plasma insulin levels and both systolic and diastolic blood pressure values in the former but not in the latter. A comparison of sex-, age-, and weight-matched hyperinsulinaemic vs normoinsulinaemic subjects showed that the former had significantly higher values of blood pressure only if not obese. These results demonstrate that the plasma insulin response to glucose is independently correlated with blood pressure.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00296995
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