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  • 1
    Electronic Resource
    Electronic Resource
    The Verona diabetes study: a population-based survey on known diabetes mellitus prevalence and 5-year all-cause mortality (1995)
    Springer
    Diabetologia 38 (1995), S. 318-325 
    Details
    ISSN: 1432-0428
    Keywords: Diabetes mellitus ; epidemiology ; mortality ; population survey ; therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary This population-based survey aimed to determine the prevalence of known diabetes mellitus on 31 December 1986, and to assess all-cause mortality in the subsequent 5 years (1987–1991) in Verona, Italy. In the study of prevalence, 5996 patients were identified by three independent sources: family physicians, diabetes clinics, and drug prescriptions for diabetes. Mortality was assessed by matching all death certificates of Verona in 1987–1991 with the diabetic cohort. Overall diabetes prevalence was 2.61% (95% confidence interval 2.56–2.67). Prevalence of insulin-dependent and non-insulin-dependent diabetes mellitus was 0.069% (0.059–0.078) and 2.49% (2.43–2.54), respectively. Diabetes prevalence sharply increased after age 35 years up to age 75–79, and finally declined. Prevalence was higher in men up to age 69 years, in women after age 75 years. Of the diabetic cohort 1260 patients (592 men, 668 women) died by 31 December 1991, yielding an overall standardized mortality ratio of 1.46 (CI 1.38–1.54). Even though the differences narrowed with age, mortality rates in the diabetic cohort were higher than in the non-diabetic population at all ages. Women aged 65–74 years showed observed/expected ratio higher than men (2.27, CI 1.92–2.66, vs 1.50, CI 1.30–1.72), while in other age groups the sex-related differences were not significant. Pharmacological treatment of diabetes was associated with an excess mortality, while treatment with diet alone showed an apparent protective effect on mortality (observed/expected ratio 0.73, CI 0.58–0.92). In conclusion, in Verona diabetes has a prevalence similar to that of other European countries, and is associated with an excess mortality which is observed in both sexes, at all ages, and with any anti-diabetic pharmacologic treatment. Diet-treated diabetes seems to be associated with a significant reduction in the mortality risk.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00400637
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  • 2
    Electronic Resource
    Electronic Resource
    Impaired glucose tolerance, Type II diabetes mellitus and carotid atherosclerosis: prospective results from the Bruneck Study (2000)
    Springer
    Diabetologia 43 (2000), S. 156-164 
    Details
    ISSN: 1432-0428
    Keywords: Keywords Impaired glucose tolerance, Type II diabetes mellitus, atherosclerosis, carotid arteries, cardiovascular risk factors.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstracts Aims/hypothesis. Cardiovascular disease is a well-known severe complication of impaired glucose tolerance and Type II (non-insulin-dependent) diabetes mellitus. The independent contribution of glucose intolerance to cardiovascular disease and the underlying pathogenic mechanisms are still, however, not clear.¶Methods. In this prospective population-based study, 826 subjects aged 40–79 years underwent high resolution duplex ultrasound examinations of carotid arteries and extensive clinical and laboratory screenings for potential vascular risk factors at baseline and 5 years later. The ultrasound protocol involved measurements of maximum axial diameter of atherosclerotic plaques, if any, in common and internal carotid arteries on both sides and enable differentiation of two main stages in carotid artery disease, termed early non-stenotic and advanced stenotic atherosclerosis. Intima-media thickness was assessed at the follow-up examination.¶Results. Type II diabetes and, to a lesser extent, impaired glucose tolerance were found to be statistically significant risk predictors of 5-year changes in carotid atherosclerosis. These associations were in part independent of other vascular risk factors typically clustering with glucose intolerance. Both impaired glucose tolerance and Type II diabetes mellitus were not independently related to early non-stenotic atherosclerosis. In contrast, Type II diabetes mellitus was the strongest single risk predictor of advanced stenotic atherosclerosis [odds ratio 5.0 (95 % confidence intervals 2.3–11.1)] and impaired glucose tolerance was of relevance as well [odds ratio 2.8 (1.2–6.4)] (p 〈 0.001).¶Conclusion/interpretation. Impaired glucose tolerance and, to a greater extent, Type II diabetes were strong independent predictors of advanced carotid atherosclerosis in our prospective population-based study. [Diabetologia (2000) 43: 156–164]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250050024
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  • 3
    Electronic Resource
    Electronic Resource
    Long-term instability of fasting plasma glucose predicts mortality in elderly NIDDM patients: the Verona Diabetes Study (1995)
    Springer
    Diabetologia 38 (1995), S. 672-679 
    Details
    ISSN: 1432-0428
    Keywords: Key words Non-insulin-dependent diabetes mellitus ; mortality ; elderly ; hyperglycaemia ; glucose control.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The aim of this study was to evaluate whether long-term glucose control, as assessed by fasting plasma glucose determinations during 3 years, is a predictor of all-cause mortality in elderly NIDDM patients. Five hundred and sixty-six NIDDM patients attending the Verona Diabetes Clinic, aged 75 years and over, were followed-up from 1 January 1987 to 31 December 1991 to assess all-cause mortality. From their clinical records all fasting plasma glucose determinations available for the years 1984 to 1986 were collected and analysed. Patients were grouped in tertiles according to mean (M-FPG), coefficient of variation (CV-FPG) and trend over time (slope, S-FPG) of fasting plasma glucose during the period of retrospective evaluation. Mortality was assessed by observed/expected ratios, univariate Kaplan-Meier survival analysis and multivariate Poisson regression model. By 31 December 1991, 61 men and 127 women had died. Increased observed/expected ratios were found in women from the top M-FPG tertile, in patients (men and women) from the top CV-FPG tertile and in patients with a S-FPG less than –0.30 mmol/l per year (lowest tertile). Patients in the lowest tertile of CV-FPG and in the middle tertile of S-FPG had a reduced mortality risk. Kaplan-Meier survival analysis indicated that patients with high CV-FPG as well as those in tertiles I and III of S-FPG (i.e., those with a definitely negative or definitely positive slope) had an increased probability of dying, without any significant differences between the three tertiles of M-FPG. Poisson regression model showed that CV-FPG, but not M-FPG or S-FPG, was an independent significant predictor of mortality. These results suggest that glucose stability needs to be considered along with the absolute level of metabolic control when treating elderly NIDDM patients. [Diabetologia (1995) 38: 672–679]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00401838
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Long-term instability of fasting plasma glucose predicts mortality in elderly NIDDM patients: the Verona Diabetes Study (1995)
    Springer
    Diabetologia 38 (1995), S. 672-679 
    Details
    ISSN: 1432-0428
    Keywords: Non-insulin-dependent diabetes mellitus ; mortality ; elderly ; hyperglycaemia ; glucose control
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The aim of this study was to evaluate whether long-term glucose control, as assessed by fasting plasma glucose determinations during 3 years, is a predictor of all-cause mortality in elderly NIDDM patients. Five hundred and sixty-six NIDDM patients attending the Verona Diabetes Clinic, aged 75 years and over, were followed-up from 1 January 1987 to 31 December 1991 to assess all-cause mortality. From their clinical records all fasting plasma glucose determinations available for the years 1984 to 1986 were collected and analysed. Patients were grouped in tertiles according to mean (M-FPG), coefficient of variation (CV-FPG) and trend over time (slope, S-FPG) of fasting plasma glucose during the period of retrospective evaluation. Mortality was assessed by observed/expected ratios, univariate Kaplan-Meier survival analysis and multivariate Poisson regression model. By 31 December 1991, 61 men and 127 women had died. Increased observed/expected ratios were found in women from the top M-FPG tertile, in patients (men and women) from the top CV-FPG tertile and in patients with a S-FPG less than −0.30 mmol/l per year (lowest tertile). Patients in the lowest tertile of CV-FPG and in the middle tertile of S-FPG had a reduced mortality risk. Kaplan-Meier survival analysis indicated that patients with high CV-FPG as well as those in tertiles I and III of S-FPG (i.e., those with a definitely negative or definitely positive slope) had an increased probability of dying, without any significant differences between the three tertiles of M-FPG. Poisson regression model showed that CV-FPG, but not M-FPG or S-FPG, was an independent significant predictor of mortality. These results suggest that glucose stability needs to be considered along with the absolute level of metabolic control when treating elderly NIDDM patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00401838
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    The Verona diabetes study: a population-based survey on known diabetes mellitus prevalence and 5-year all-cause mortality (1995)
    Springer
    Diabetologia 38 (1995), S. 318-325 
    Details
    ISSN: 1432-0428
    Keywords: Key words Diabetes mellitus ; epidemiology ; mortality ; population survey ; therapy.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary This population-based survey aimed to determine the prevalence of known diabetes mellitus on 31 December 1986, and to assess all-cause mortality in the subsequent 5 years (1987–1991) in Verona, Italy. In the study of prevalence, 5996 patients were identified by three independent sources: family physicians, diabetes clinics, and drug prescriptions for diabetes. Mortality was assessed by matching all death certificates of Verona in 1987–1991 with the diabetic cohort. Overall diabetes prevalence was 2.61 % (95 % confidence interval 2.56–2.67). Prevalence of insulin-dependent and non-insulin-dependent diabetes mellitus was 0.069 % (0.059–0.078) and 2.49 % (2.43–2.54), respectively. Diabetes prevalence sharply increased after age 35 years up to age 75–79, and finally declined. Prevalence was higher in men up to age 69 years, in women after age 75 years. Of the diabetic cohort 1260 patients (592 men, 668 women) died by 31 December 1991, yielding an overall standardized mortality ratio of 1.46 (CI 1.38–1.54). Even though the differences narrowed with age, mortality rates in the diabetic cohort were higher than in the non-diabetic population at all ages. Women aged 65–74 years showed observed/expected ratio higher than men (2.27, CI 1.92–2.66, vs 1.50, CI 1.30–1.72), while in other age groups the sex-related differences were not significant. Pharmacological treatment of diabetes was associated with an excess mortality, while treatment with diet alone showed an apparent protective effect on mortality (observed/expected ratio 0.73, CI 0.58–0.92). In conclusion, in Verona diabetes has a prevalence similar to that of other European countries, and is associated with an excess mortality which is observed in both sexes, at all ages, and with any anti-diabetic pharmacologic treatment. Diet-treated diabetes seems to be associated with a significant reduction in the mortality risk. [Diabetologia (1995) 38: 318–325]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00400637
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    Paper (German National Licenses)
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  • 6
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    Il "castrum Pertice". Notizie preliminari sulle campagne di scavo 1982 e 1983 in località Sant' Antonino, Finale Ligure (Savona) (1984)
    Firenze : Periodicals Archive Online (PAO)
    Archeologia medievale. 11 (1984) 215 
    Details
    ISSN: 0390-0592
    Topics: Archaeology , History , Art History
    Notes: "NOTIZIE, SCAVI E LAVORI SUL CAMPO"
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:e315-1984-011-00-000005
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  • 7
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    Il "castrum" tardo-antico di S. Antonino di Perti, Finale Ligure (Savona): fasi stratigrafiche e reperti dell'area D. Seconde notizie preliminari sulle campagne di scavo 1982-1987 (1988)
    Firenze : Periodicals Archive Online (PAO)
    Archeologia medievale. 15 (1988) 335 
    Details
    ISSN: 0390-0592
    Topics: Archaeology , History , Art History
    Notes: "NOTIZIE, SCAVI E LAVORI SUL CAMPO"
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:e315-1988-015-00-000008
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  • 8
    Electronic Resource
    Electronic Resource
    Relationship between blood pressure and plasma insulin in non-obese and obese non-diabetic subjects (1987)
    Springer
    Diabetologia 30 (1987), S. 719-723 
    Details
    ISSN: 1432-0428
    Keywords: Insulin ; blood pressure ; obesity ; healthy man ; oral glucose tolerance test
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In this study, we have measured plasma insulin at fasting and following an oral glucose load and blood pressure after glucose load in 367 (247 non-obese, 120 obese) normotensive and untreated mildly hypertensive subjects. Overall, there was no independent association between fasting plasma insulin levels and blood pressure values. After controlling for age and body weight, a significant relationship between postglucose plasma insulin levels and diastolic blood pressure was found. When non-obese and obese subjects were examined separately, significant relationships were identified between postglucose plasma insulin levels and both systolic and diastolic blood pressure values in the former but not in the latter. A comparison of sex-, age-, and weight-matched hyperinsulinaemic vs normoinsulinaemic subjects showed that the former had significantly higher values of blood pressure only if not obese. These results demonstrate that the plasma insulin response to glucose is independently correlated with blood pressure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00296995
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  • 9
    Electronic Resource
    Electronic Resource
    Insulin and C-peptide plasma levels in patients with severe chronic pancreatitis and fasting normoglycemia (1988)
    Springer
    Digestive diseases and sciences 33 (1988), S. 732-736 
    Details
    ISSN: 1573-2568
    Keywords: chronic pancreatitis ; insulin, C-peptide ; B cell ; liver ; insulin metabolism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The aim of the present study was to evaluate insulin secretion by the pancreatic B cell in a group of patients with severe chronic pancreatitis and without overt diabetes. For this purpose we have measured plasma insulin and C-peptide peripheral levels in the fasting state and after a 100-g oral glucose load in 10 patients with severe chronic pancreatitis and fasting normoglycemia, and in 10 sex-, age-, and weight-matched healthy controls. As compared to normal subjects, patients with chronic pancreatitis showed: (1) significantly higher plasma glucose levels after oral glucose load (area under the plasma glucose curve 1708±142 vs 1208±47 mmol/liter × 240 min, P 〈 0.005); (2) plasma insulin levels significantly higher at fasting (0.11±0.008 vs 0.08±0.005 nmol/liter, P 〈 0.01) but not after oral glucose administration (area under the plasma insulin curve 79±12 vs 88 ±16 nmol/liter × 240 min); (3) significantly lower plasma C-peptide concentrations both in the fasting state (0.15±0.01 vs 0.54±0.05 nmol/liter, P〈0.001) and after oral glucose load (area under the plasma C-peptide curve 211±30 vs 325±37 nmol/liter × 240 min, P〈0.05). The finding of diminished plasma C-peptide levels suggests that chronic pancreatitis is associated with an impaired B-cell function even in the absence of overt diabetes. The increased or unchanged plasma insulin levels in spite of decreased plasma C-peptide concentrations indicate that in chronic pancreatitis insulin metabolism is reduced, most likely within the liver.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01540438
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