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  • 1
    Electronic Resource
    Electronic Resource
    Teratocarcinogenesis as related to the age of embryos grafted under the kidney capsule (1971)
    Springer
    Development genes and evolution 167 (1971), S. 288-290 
    Details
    ISSN: 1432-041X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Mouse egg-cylinders of C3H/H strain with two and three germ layers were transplanted under the kidney capsule. They developed into well differentiated teratomas and teratocarcinomas. Older embryos developed invariably into teratomas composed of adult tissues only. We consider the period of germ layer inversion as a critical stage when embryonic cells loose their potentiality for uncontrolled growth.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00584254
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  • 2
    Electronic Resource
    Electronic Resource
    Ultrastructure of mouse egg-cylinder (1970)
    Springer
    Anatomy and embryology 132 (1970), S. 291-298 
    Details
    ISSN: 1432-0568
    Keywords: Egg-cylinder ; Mouse ; Germ layers ; Differentiation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The mouse egg-cylinder prior to and after mesoderm formation was studied by means of electron microscopy. The ultrastructural appearance of the proximal entoderm of both embryonic and extraembryonic segments suggests an intensive absorptive and nutritional activity. Numerous pinocytotic vacuoles, microvilli, primary and secondary lysosomes and fair amounts of rough endoplasmic reticulum and free ribosomes were the most important characteristics of these cells. After mesoderm formation, the extraembryonic entoderm showed the aforementioned characteristics even more prominently, while the cells of embryonic entoderm became flattened and depleted of microvilli and of almost all organelles. The cells of the extraembryonic and embryonic ectoderm prior to and after mesoderm formation had the same ultrastructural appearance as mesodermal cells. The cytoplasm of these cells was replete with free ribosomes, but other organelles such as mitochondria and rough endoplasmic reticulum were few in number. The architecture of all cells of the egg-cylinder except those of the extraembryonic entoderm suggested a very low level of differentiation. The criteria and possibilities for the determination of the degree of differentiation on the ultrastructural level and possible differences in protein synthesis in extraembryonic entoderm as compared with other parts of the embryo are considered.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00569266
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  • 3
    Electronic Resource
    Electronic Resource
    Distribution of hydrolytic enzymes in early rat and mouse embryos — A reappraisal (1973)
    Springer
    Anatomy and embryology 139 (1973), S. 119-126 
    Details
    ISSN: 1432-0568
    Keywords: Cleavage stages ; Egg-cylinder ; Mouse ; Rat ; Hydrolytic enzymes distribution ; Differentiation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The time of appearance and the distribution of alkaline and acid phosphatase and nonspecific esterase was investigated in cleavage and early postimplantation stages of mouse and rat embryos. Alkaline and acid phosphatase appeared for the first time in 8-cell embryos. Activity of both enzymes grew progressively stronger to blastocyst stage. Acid phosphatase activity was revealed in the form of fine and coarse granules distributed evenly in the cytoplasm. Alkaline phosphatase was predominantly localized in plasma membranes. There was no difference in intensity of reaction between trophoblastic cells and the inner cell mass. After implantation acid phosphatase was localized in coarse granules in the apical portion of entodermal cells. With the appearance of mesoderm, the cells of embryonal entoderm became flattened and devoid of acid phosphatase activity which was restricted to cells of extraembryonic entoderm. The activity of nonspecific esterase was not detected in preimplantation stages. In postimplantation embryos it roughly corresponded to the activity of acid phosphatase. Alkaline phosphatase was localized in cell membranes of ectodermal cells. The mesodermal cells of mouse embryo displayed a somewhat weaker activity than ectodermal cells, while in the rat embryo the same layer remained completely nonreactive. Our findings on the distribution of the enzymes mentioned did not reveal any kind of polarity or bilateral symmetry in preimplantation stages. In postimplantation stages acid phosphatase and nonspecific esterase are probably bound to lysosomes and play an important role in embryonic nutrition. The absence of alkaline phosphatase from entodermal cells is somewhat puzzling and suggests that the process of molecular transport in those cells is most probably restricted to endocytosis. Our results suggest that all blastomeres are identical with respect to enzyme distribution and that the first signs of differentiation of enzyme content appear with the formation of germ layers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00523633
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  • 4
    Electronic Resource
    Electronic Resource
    Embryo-derived teratocarcinomas elicit splenomegaly in syngeneic host (1974)
    [s.l.] : Nature Publishing Group
    Nature 249 (1974), S. 569-571 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Seven-day-old mouse egg-cylinders (the day when the vaginal plug was found was considered day 0) were isolated from uterine swellings of pregnant C3H/H mice and transplanted under the kidney capsules or into ithe testes of 6-8-week-old syngeneic or (C57BL X C3H/H)Fi hybrid recipients as ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/249569a0
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  • 5
    Electronic Resource
    Electronic Resource
    Extrauterine Growth of Mouse Egg-cylinders results in Malignant Teratoma (1970)
    [s.l.] : Nature Publishing Group
    Nature 227 (1970), S. 503-504 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The egg-cylinder stage at which all extraembryonic material can be dispensed with is the most suitable model to use for elucidating the differentiation and histogenesis of mature tissues. Long term transplantations of rat egg-cylinders have been carried out in our laboratory^(unpublished results of ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/227503a0
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Chondrolipoma of the Breast (2005)
    Oxford, UK : Blackwell Science Inc
    The @breast journal 11 (2005), S. 0 
    Details
    ISSN: 1524-4741
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1075-122X.2005.21468.x
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  • 7
    Electronic Resource
    Electronic Resource
    Recent advances in the understanding of the pathology of testicular germ-cell tumors (1984)
    Springer
    World journal of urology 2 (1984), S. 12-17 
    Details
    ISSN: 1433-8726
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Most testicular cancers probably arise in intratubular germ cells. This article proposes that tumorigenesis involves two steps: activation of the germ cells, which can result either in simple proliferation (intratubular atypia) or in parthenogenetic development (teratomas), and malignant transformation, either simultaneously (embryonal carcinoma) of later (tumors with restricted developmental potential). The embryonal carcinoma cells then may be able to differentiate into the other types of nonseminomatous tumors according to the traditional schema. This model implies that histologically similar tumors have different origins and destinies. The clinical implications are discussed briefly.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00326927
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  • 8
    Electronic Resource
    Electronic Resource
    Intermediate filaments of human trophoblast and choriocarcinoma cell lines (1985)
    Springer
    Virchows Archiv 407 (1985), S. 203-208 
    Details
    ISSN: 1432-2307
    Keywords: Placenta ; Keratin ; Vimentin ; Choriocarcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Human term placenta and two human choriocarcinoma cell lines were studied immunohistochemically and by immunoblotting with monoclonal antibodies to keratin polypeptides and vimentin. Four keratin polypeptides (40, 45, 52, 54 K) were detected in both normal and malignant trophoblastic cells. The presence of the 54 K keratin polypeptide distinguishes the benign and malignant trophoblastic cells from human embryonal carcinoma cells and a yolk sac carcinoma cell line.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00737077
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  • 9
    Electronic Resource
    Electronic Resource
    Heterogeneity of basement membranes in normal and pathologically altered tissues (1990)
    Springer
    Virchows Archiv 416 (1990), S. 185-188 
    Details
    ISSN: 1432-2307
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01678976
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  • 10
    Electronic Resource
    Electronic Resource
    Undifferentiated carcinoma of the colon containing exocrine, neuroendocrine and squamous cells (1983)
    Springer
    Virchows Archiv 401 (1983), S. 57-66 
    Details
    ISSN: 1432-2307
    Keywords: Keratin ; Alpha-1-antitrypsin ; Lysozyme
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The light microscopic, electron microscopic and histochemical features of a highly malignant colonic tumor resected from a 39 year old man are presented. The tumor was composed predominantly of undifferentiated cells, with focally admixed neuroendocrine, exocrine and squamous cells, occasionally arranged in an organoid manner. Histochemically the tumor contained argyrophilic cells as well as cells that reacted positively with the antibodies to alpha-1-antitrypsin, alpha-1-antichymotrypsin, carcinoembryonic antigen and lysozyme. The term “stem cell carcinoma of the intestine” is proposed for this highly malignant tumor composed of undifferentiated cells exhibiting only focally their multidirectional developmental capacity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00644789
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