ISSN:
1573-6873
Keywords:
cellular short-term memory
;
inactivation
;
potassium conductance
;
biophysical model
Source:
Springer Online Journal Archives 1860-2000
Topics:
Computer Science
,
Medicine
,
Physics
Notes:
Abstract We analyzed the cellular short-term memory effects induced by a slowly inactivating potassium (Ks) conductance using a biophysical model of a neuron. We first described latency-to-first-spike and temporal changes in firing frequency as a function of parameters of the model, injected current and prior history of the neuron (deinactivation level) under current clamp. This provided a complete set of properties describing the Ks conductance in a neuron. We then showed that the action of the Ks conductance is not generally appropriate for controlling latency-to-first-spike under random synaptic stimulation. However, reliable latencies were found when neuronal population computation was used. Ks inactivation was found to control the rate of convergence to steady-state discharge behavior and to allow frequency to increase at variable rates in sets of synaptically connected neurons. These results suggest that inactivation of the Ks conductance can have a reliable influence on the behavior of neuronal populations under real physiological conditions.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1008902110844
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