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  • 1
    Electronic Resource
    Electronic Resource
    The unusual metal status of the dugong Dugon dugon (1980)
    Springer
    Marine biology 57 (1980), S. 201-219 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Using atomic absorption spectroscopy, exceptionally high concentrations of iron (778 to 82,363 μg g+1 dry weight) and zinc (219 to 4,183 μg g+1 dry weight) were detected in the livers of Dugong dugon (Müller) from north Queensland compared with reported values for other marine mammals from other areas of the world. Levels of copper (9.1 to 608 μg g+1 dry weight), cadmium (〈0.1 to 59 μg g+1 dry weight), cobalt (0.5 to 72 μg g+1 dry weight) and silver (0.2 to 39 μg g+1 dry weight) in the liver, and cadmium (0.2 to 209 μg g+1 dry weight) in the kidney were also relatively high in several samples, whilst concentrations of nickel, lead and chromium were consistently below the limits of detection in all tissues. Manganese concentrations, in all tissues examined, were generally comparable with those reported from other marine mammals. Tissue concentrations of a number of metals varied with the age of the dugong. Levels of iron, zinc, cadmium and cobalt in the liver zinc and cadmium in the kidney, and iron in the muscle were significantly positively correlated with age. Copper and manganese in both liver and kidney were negatively correlated with age. Large deposits of the iron-rich pigment, haemosiderin, the quantity of which also tended to increase with age, was a conspicuous feature of the livers of all the post-natal dugongs examined histologically. It seems unlikely that the unusual metal status of the dugong reflects anthropogenic activities, since many individuals were collected in remote areas far from major sites of urbanization and industrialization. Seagrasses, the major food of dugongs, were collected from various north Queensland dugong habitat-areas and analysed. Very high concentrations of iron but low levels of copper were detected. The significance of such dietary imbalances and their possible influence on the metal status of the dugong were therefore considered.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00390738
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  • 2
    Electronic Resource
    Electronic Resource
    Influence of temperature and salinity on the uptake, distribution and depuration of mercury, cadmium and lead by the black-lip oyster Saccostrea echinata (1981)
    Springer
    Marine biology 64 (1981), S. 317-326 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Saccostrea echinata (Quoy and Gaimard) were exposed to 10 μg 1-1 of either mercury, cadmium or lead at 30 °C, 36‰S; 30 °C, 20‰S; 20°C, 36‰S and 20°C, 20‰S for 30 d and were then transferred to clean seawater for a further 30 d to depurate. Specimens were removed at regular intervals during the exposure and depuration periods, dissected into gills, mantle, visceral mass and adductor, and analysed for the appropriate metal by atomic absorption spectroscopy. Mercury was concentrated more than the other metals in all tissues under all conditions. Cadmium uptake was greater than lead in all tissue in the high-temperature experiments, whereas both metals were concentrated to similar extents at low temperature. The gill tissue generally accumulated the greatest amount of all 3 metals, whilst the adductor concentrated the least amount. At both salinities, mercury and cadmium accumulation by all tissues was significantly greater at the higher temperature whereas lead uptake was only marginally increased. The accumulation rates of mercury at high temperature were significantly greater in all tissues at low compared with high salinity, whereas at low temperature, differences were not significant. Accumulation rates of cadmium and lead in the majority of tissues examined were significantly greater in lowsalinity water at both temperatures. In general, lead was lost the most rapidly from oyster tissues, followed by mercury and then cadmium. The residence times for mercury and cadmium differed significantly between tissues, with the gills showing the highest turnover rate. In contrast, residence times for lead were similar between tissues. Losses of all 3 metals from oyster tissues were not obviously influenced by temperature and only mercury losses differed significantly between salinities.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00393633
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  • 3
    Electronic Resource
    Electronic Resource
    Femtosecond transient photoinduced transmission measurements on a novel conjugated zinc porphyrin system (1996)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 104 (1996), S. 805-811 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: We present a comparative study on the ultrafast nonlinear optical response of a novel conjugated zinc porphyrin system. The linear optical absorption spectra of these molecules all show the Q-band and B-band transitions of the basic porphyrin unit. We have taken spectrally resolved ultrafast pump–probe measurements on monomer, dimer, and polymer solutions, which allows us to compare their excited state dynamics and relate these to their linear optical absorption. The spectra show several common features, but these features have markedly different decay dynamics. The bleaching is preferential in the Q band for the polymer and the B band for the monomer. The polymer Q-band bleaching shows a two-component decay, of approximately 700 fs and 170±50 ps time constants in a biexponential fit, which we attribute to both exciton–exciton annihilation and exciton diffusion to recombination centers on the polymer chain. The Q band of the dimer also has a two-component decay with 13±5 and 1250±70 ps time constants which we attribute to rotational diffusion of the excited molecule in solution, and decay to the ground state, respectively. The B-band bleaching in the monomer is long lived and has a decay constant of approximately 3.5±0.5 ns; from the absorption recovery of the B band we estimate a triplet yield of 0.8. All molecules exhibit broad π*−π* absorptions in the visible spectral region (between the Q band and the B band). In particular, we show that the monomer has potential as a broadband optical limiter in the visible region from 455 (2.72 eV) to 620 nm (2.00 eV); we estimate that its excited state absorption cross section is 8.5 times that of its ground state cross section at 532 nm (2.33 eV). There is also clear evidence of triplet transitions in the dimer and monomer; the triplet absorption feature ranging from 940 (1.32 eV) to 1000 nm (1.24 eV) rises 10 ps after excitation in the dimer which suggests a short intersystem-crossing time. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.470805
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  • 4
    Electronic Resource
    Electronic Resource
    First record of the rust Puccinia lagenophorae on Emilia spp. in the UK (2005)
    Oxford, UK : Blackwell Science Ltd
    Plant pathology 54 (2005), S. 0 
    Details
    ISSN: 1365-3059
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3059.2004.01152.x
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  • 5
    Electronic Resource
    Electronic Resource
    First report of fruit rot caused by Phytophthora syringae on Pyracantha in the UK (2004)
    Oxford, UK : Blackwell Science Ltd
    Plant pathology 53 (2004), S. 0 
    Details
    ISSN: 1365-3059
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3059.2004.01080.x
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  • 6
    Electronic Resource
    Electronic Resource
    Biexcitonic contribution to polarization-dependent degenerate four-wave mixing in GaAs quantum wells (1995)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 67 (1995), S. 238-240 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We report measurements of the polarization and time-averaged intensity of four-wave mixing signals from GaAs quantum wells as functions of the pump beam polarizations, laser photon energy, and optical injection density, the latter covering a range of higher levels than has previously been reported. Excitation of heavy-hole excitons produced a sin2 variation of the signal intensity as the pump beam polarizations changed from parallel to perpendicular, while injection of light-hole excitons led to an approximately cos2 dependence. The tuning dependence of the heavy-hole-exciton signal revealed a low-energy signal which is attributed to biexcitons. The dominance of this signal for perpendicular polarization causes the observed sin2 variation of the heavy-hole-exciton signal. © 1995 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.114679
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  • 7
    Electronic Resource
    Electronic Resource
    Immunization with Human Monoclonal Antiidiotypic Antibody in Colorectal Cancer (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 690 (1993), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1993.tb44022.x
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  • 8
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    Unknown
    Early Psychological Theories of Herbert Spencer. (1921)
    Urbana, etc. : Periodicals Archive Online (PAO)
    American Journal of Psychology. 32 (1921) 5 
    Details
    ISSN: 0002-9556
    Topics: Psychology
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:1016-1921-000-00-000011
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  • 9
    Electronic Resource
    Electronic Resource
    Preclinical evaluation of copper-67 labelled anti-MUC1 mucin antibody C595 for therapeutic use in bladder cancer (1997)
    Springer
    European journal of nuclear medicine 24 (1997), S. 439-443 
    Details
    ISSN: 1619-7089
    Keywords: Key words: Radioimmunotherapy ; MUC1 mucin ; Monoclonal antibody ; Copper-67 ; Bladder cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Transitional cell carcinoma of the bladder is the fifth commonest cause of death from cancer in men in the United Kingdom. Most patients present early with superficial disease, though with current treatment up to 20% progress to invasive disease, which has a poor prognosis. Better local treatments are required to limit this tumour progression. The ease of access to the bladder via a catheter provides the ideal opportunity for antibody (Ab) targeted therapy. We have previously shown that indium-111 labelled anti-MUC1 mucin Ab C595 selectively localises to bladder tumours after intravesical administration. We have selected copper-67 as an alternative radiolabel with suitable physical characteristics for radioimmunotherapy. This communication demonstrates that C595 can be reproducibly labelled with 67Cu and that the radioimmunoconjugate is both stable and maintains high immunoreactivity. Pilot studies on cystectomy specimens in a novel ex vivo system and in one patient confirmed the ability of this conjugate to localise to tumour after intravesical administration. On the basis of these studies we are now in a position to study the intravesical administration of 67Cu-labelled C595 in patients with bladder cancer with a view to a therapeutic trial.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00881818
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  • 10
    Electronic Resource
    Electronic Resource
    Preclinical evaluation of copper-67 labelled anti-MUC1 mutin antibody C595 for therapeutic use in bladder cancer (1997)
    Springer
    European journal of nuclear medicine 24 (1997), S. 439-443 
    Details
    ISSN: 1619-7089
    Keywords: Radioimmunotherapy ; MUC1 mucin ; Monoclonal antibody ; Copper-67 ; Bladder cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Transitional cell carcinoma of the bladder is the fifth commonest cause of death from cancer in men in the United Kingdom. Most patients present early with superficial disease, though with current treatment up to 20% progress to invasive disease, which has a poor prognosis. Better local treatments are required to limit this tumour progression. The ease of access to the bladder via a catheter provides the ideal opportunity for antibody (Ab) targeted therapy. We have previously shown that indium-111 labelled anti-MUCI mucin Ab C595 selectively localises to bladder tumours after intravesical administration. We have selected copper-67 as an alternative radiolabel with suitable physical characteristics for radioimmunotherapy. This communication demonstrates that C595 can be reproducibly labelled with67Cu and that the radioimmunoconjugate is both stable and maintains high immunoreactivity. Pilot studies on cystectomy specimens in a novel ex vivo system and in one patient confirmed the ability of this conjugate to localise to tumour after intravesical administration. On the basis of these studies we are now in a position to study the intravesical administration of67Cu-labelled C595 in patients with bladder cancer with a view to a therapeutic trial.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00881818
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