ISSN:
1617-4623
Keywords:
Key wordsArabidopsis thaliana
;
Glutathione-conjugate pump
;
Stress
;
Xenobiotic detoxification
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Abstract In all organisms glutathione-conjugate transporters (GS-X pumps) mediate the detoxification of a number of xenobiotics by removing them from the cytosol. In addition, GS-X pumps appear to play a role in the processing of endogenous compounds. We have isolated a novel genomic clone from Arabidopsis thaliana that encodes a putative GS-X pump, AtMRP4, which is part of a recently defined gene family. The derived amino acid sequence shares high levels of similarity (55–63%) with human, yeast, and other Arabidopsis homologues. The expression of the different members of the AtMRP gene family in Arabidopsis cell suspensions after treatment with chemicals that modify glutathione metabolism (compounds that induce different types of stress and that act as herbicide antidotes – safeners – in monocotyledonous species) revealed that the members of this gene family are differentially regulated.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s004380050779
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