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  • 1
    Electronic Resource
    Electronic Resource
    Sea water consumption by two strains of mice (1968)
    Springer
    Cellular and molecular life sciences 24 (1968), S. 145-146 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Résumé Deux espèces de souris (IHB et A) vécurent 1 an avec un régime d'eau de mer ad libitum et d'aliments secs. La haute osmolarité urinaire, la capacité élevée de concentrer le sodium et l'absence de diarrhée furent des facteurs qui leur permirent de supporter ce régime expérimental.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02146949
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Dentatectomy: Absence of effects on dyskinesias arizing from chemical stimulation of the striatum in rats (1972)
    Springer
    Cellular and molecular life sciences 28 (1972), S. 37-38 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Elektrolytische, ipsilaterale, kontralaterale oder bilaterale Läsionen blieben in den tiefen Kernen des Cerebellums ohne Einfluss auf Intensität oder Charakter von Dyskinesien, welche durch Injektionen von 1,5 μg Carbachol in den Caudatum-Putamen-Komplex ungehindert beweglicher Ratten hervorgerufen wurden.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01928250
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Phenytoin-induced DNA synthesis and inositol 1,4,5-triphosphate formation in L-929 fibroblasts (1991)
    Springer
    Cellular and molecular life sciences 47 (1991), S. 728-730 
    Details
    ISSN: 1420-9071
    Keywords: Phenytoin ; fibroblasts ; inositol phosphates ; DNA synthesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Culture of L-929 fibroblasts in the presence of phenytoin (2.5–5.0 μg/ml) increased DNA synthesis, as indicated by increased [3H]thymidine uptake, while a higher dose (20 μg/ml) inhibited DNA synthesis. In like manner, a low dose of phenytoin (5.0 μg/ml) was effective in increasing inositol 1,4,5-trisphosphate formation while a higher dose (10 μg/ml) tended to inhibit this activity. These data suggest that the formation of inositol phosphate second messengers may play a role in phenytoin-induced fibroblast proliferation and connective tissue growth.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01958828
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Phenytoin-induced connective tissue growth in the rat (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 215 (1986), S. 99-105 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Rats were treated daily for 9 days with 100, 50, or 25 mg/kg phenytoin i.p. This treatment resulted in a significant increase in the thickness of the connective tissue capsules of the liver, spleen, and pancreas, and of the subepithelial connective tissue of the mesentery but not the epicardium or visceral pleura of the lung where exposure to the drug was via the vascular route. Many areas of connective tissue growth exhibited obvious proliferation of fibroblasts and in some areas contained seemingly large numbers of macrophages and an increase in vascularity. It was demonstrated by electron microscopy that the macrophages occasionally were seen in intimate contact with the fibroblasts.Our observations clearly showed that intraperitoneal exposure of visceral connective tissues of the rat to phenytoin rapidly resulted in a dose-related proliferation of that tissue. The presence of numerous macrophages leads to the suggestion that macrophage-derived growth factor could be responsible for the increased growth.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1092150203
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    Paper (German National Licenses)
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