ISSN:
0749-1581
Keywords:
Long-range CH correlation
;
Correlation by long-range coupling
;
One-bond CH correlation
;
COSY Intensity optimization
;
Dibromochloropropane metabolite
;
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Complete 13C and 1H spectral peak assignments of S-(2,3-dihydroxy-1-propyl)glutathione (1) (an in vivo metabolite of the pesticide 1,2-dibromo-3-chloropropane) were made using various 2D NMR techniques. Long-range CH correlation 2D NMR unambiguously assigned the key methylene resonances adjacent to sulfur. Appropriate delays for optimum cross-peak intensities in the long-range correlation experiment were chosen with response intensity curves, generated using estimated long-range coupling constants. These curves, although generated assuming a first-order coupling network, are useful even in systems with strong second-order couplings as in 1.
Additional Material:
5 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/mrc.1260260703
Permalink