ISSN:
1573-2568
Keywords:
GASTRIC ULCER
;
PROTON PUMP INHIBITOR
;
MUCOSAL PROTECTIVE DRUGS
;
BILE REFLUX
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract c-Kit is a receptor tyrosine kinase, and it isencoded by the mouse W locus. Mutant W/Wvmice develop spontaneous gastric antral ulcers. The aimof the present study was to investigate the pathogenesis of these gastric ulcers and to examine theeffects of two antiulcer drugs; a proton pump inhibitor(2{[4-(3-methoxypropoxy)-3-methylpyridine-2-yl]methyl-sulfinyl}-1H-benzimidazole sodium salt, rabeprazole) and a mucosal protective drug(geranylgeranylacetone, GGA), on the gastric ulcers. Theinhibition of the gastric acid secretion by rabeprazole(30 mg/kg body weight, subcutaneous injection once a dayfor six weeks) significantly increased the gastriculcer formation compared to the controls. In contrast,the GGA treatment (100 mg/kg body weight, oraladministration for six weeks) significantly inhibited the ulcer formation. Bile reflux was seen inthese mutant mice, and they showed no cyclic intensecontractions in the gastric antrum. These resultssuggest that bile reflux due to the disturbance ofgastric antral movement is a cause of the spontaneousgastric ulcers in W/Wv mice.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1026684425642
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