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  • 1
    Electronic Resource
    Electronic Resource
    Randomised trial of immediate versus deferred treatment strategies for the management of minor cervical cytological abnormalities (1997)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 104 (1997), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objective To compare immediate and deferred treatment in women with cervical smears showing borderline nuclear abnormalities or mild dyskaryosis.Design Prospective randomised trial.Setting Colposcopy clinics at Birmingham and Midland Hospital for Women and the City Hospital NHS Trust, Dudley Road, Birmingham.Participants Four hundred and thirty-five women with minor cytological abnormality younger than 35 years of age, of whom 353 were randomised to immediate treatment or deferred treatment.Main outcome measures Comparison of histologies in the subsequent two years in the immediate and deferred treatment groups.Results Thirty-six women (21%) defaulted from follow up. The percentage of high grade abnormalities (CIN II and III) in the deferred treatment arm at two years is similar to that in the immediate treated arm at first colposcopy (25%vs24%). Cytology failed to pick up two cases of CIN III and there was one case of early invasive carcinoma at the six month follow up. If treatment is deferred, the proportion with CIN I is almost halved (25%vs13%); the proportion with koilocytic atypia is slightly reduced (51%vs42%) and the proportion with no abnormality is substantially increased (0.6% vs 20%).Conclusion Immediate referral and a select-and-treat management strategy of all women with any degree of dyskaryosis is recommended based on the case of invasive cervical cancer, high default rate and the failure of cytology to pick up two cases of CIN III.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1997.tb11538.x
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  • 2
    Electronic Resource
    Electronic Resource
    Abnormal cervical cytology following large loop excision of the transformation zone: a case controlled study (1993)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 100 (1993), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objectives To determine factors that may predict cytological outcome at 6 months following large loop excision of transformation zone (LLETZ) for cervical intra epithelial neoplasia (CIN) and to investigate the outcome in women with continuing cytological abnormality.Design Case controlled retrospective study.Setting Dudley Road Hospital, Birmingham and Midland Hospital for Women.Subjects Fifty-eight women with abnormal follow up cytology and a control group of 116 women.Main outcome measures The relation between pretreatment and treatment factors and cytological outcome, and the relation between cytology and histology in women who had biopsies for persistent adnormal cytology.Results Univariate and stepwise logistic regression analysis showed that the number of sectors of atypical transformation zone (lesion size) and the excision margin status of the large loop excision specimen are of prognostic importance for the prediction of cytological abnormality at the 6 month follow up visit. Sixteen women have undergone further cervical biopsy. Of the five cases of persistent CIN, four had cytological changes showing moderate or severe dyskaryosis. Of the 11 women with koilocytosis or normal histology, 10 had mild dyskaryosis or borderline changes on their follow up cytology.Conclusion Lesion size and excision margin status are important correlates of follow up cytology when treating patients for CIN with LLETZ. All women with abnormal cervical cytology at follow up should undergo colposcopic assessment. Excision biopsy is indicated if follow up cytology shows moderate or severe dyskaryosis, especially if still present 12 months after treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1993.tb15210.x
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  • 3
    Electronic Resource
    Electronic Resource
    Digital imaging colposcopy, image analysis and quantification of the colposcopic image (1994)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 101 (1994), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objective To investigate the use of a digital imaging system for colposcopy, its use for image analysis and quantification of the colposcopic features that may predict histological outcome as defined by large loop excision of transformation zone.Design Prospective programme study of all patients undergoing colposcopy for cytological abnormalities.Setting Dudley Road Hospital, Birmingham.Subject Fifty consecutive patients having cytological and colposcopic abnormality treated with large loop excision of transformation zone formed the study group.Main outcome measures Pretreatment and colposcopic features correlated with histological diagnosis of excised transformation zone.Results Index cytology and current smoking status are the most important variables for prediction of histological diagnosis. Other important variables are focality of lesion, surface pattern, intercapillary distance and degree of acetowhiteness.Conclusion Digital imaging colposcopy allows image capture, processing and objective analysis. This methodology holds advantages for basic and clinical research, teaching, diagnostics and clinical audit. The system can act as a quality control tool for colposcopy units. This system should prove invaluable for further quantitative studies, for natural history studies and for those patients with deferred treatment of their cytological and colposcopic abnormalities. The statistical models described may be incorporated into the system and can aid the colposcopist in management of the woman with abnormal cervical cytology and colposcopic abnormality.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1994.tb13116.x
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  • 4
    Electronic Resource
    Electronic Resource
    Accumulation of Maillard Reaction Products in Skin Collagen in Diabetes and Aging (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 663 (1992), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1992.tb38687.x
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  • 5
    Electronic Resource
    Electronic Resource
    Insecticide Resistance in the Cocoa Capsid, Distantiella theobroma (Dist.) (1963)
    [s.l.] : Nature Publishing Group
    Nature 199 (1963), S. 1207-1207 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The plot was planted in 1956 and has since received four spray applications of g-BHC each year, the initial spray of 4 oz. a.i. and all subsequent sprays of 12 oz. a.i. per acre applied in 5 gallons of water by portable, motorized mistblowers. In August 1961 it became apparent that the capsid ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/1991207a0
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  • 6
    Electronic Resource
    Electronic Resource
    Lettace Root Aphid Control by Means of Plant Resistance (1974)
    Oxford, UK : Blackwell Publishing Ltd
    Plant pathology 23 (1974), S. 0 
    Details
    ISSN: 1365-3059
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: At Wellesbourne, Warwick, in 1968, not all plants of the lettuce cv. Webb's Wonderful protected against lettuce root aphid. Pemphigus bursarius (L.), by diazinon pre-sowing treatments remained uncolonized throughout a relatively light aphid attack but no colonization of unprotected plants of cv. Avoncrisp occurred. In a second experiment in 1972, in which plants were untreated and exposed to an intense aphid attack, the lettuce cvs. Mildura, Borough Wonder, Webb's Wonderful, Avoncrisp and Avondefiance all attracted similar large numbers of winged root aphid rnigrants. No root colonies formed on the resistant CVS. Avoncrisp and Avondefiance. All plants of the other cultivars became severely damaged and most were killed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3059.1974.tb01830.x
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  • 7
    Electronic Resource
    Electronic Resource
    Leiomyosarcomas have a poorer prognosis than mixed mesodermal tumours when adjusting for known prognostic factors: the result of a retrospective study of 423 cases of uterine sarcoma (1992)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 99 (1992), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objective To determine the survival data for the various tumour types of uterine sarcoma and determine the influence of various prognostic factors on survival.Design Retrospective analysis of all uterine sarcoma cases registered in the 15 year period 1967–1981.Setting West Midlands Regional Cancer Registry, serving a catchment area of 2.6 million women.Subjects 423 women registered as having a uterine sarcoma; 367 of these were associated with the two main histological types, leiomyosarcomas (LMS) and mixed mesodermal tumours (MMT).Main outcome measures Duration of survival was taken as the primary endpoint.Results The overall 5-year survival for uterine sarcomas in this series was 31%, with the major prognostic indicator being tumour stage. Survival for mixed mesodermal tumours is similar to other sarcomas despite a tendency towards less differentiation, wider dissemination and a greater age of the patient at diagnosis. Multivariate analysis shows that for cases with similar stage, age and grade, mixed mesodermal tumours have a better prognosis than leiomyosarcomas.Conclusions These results demonstrate the danger of considering each variable in isolation when the relation between variables can lead to spurious significance or lack of significance because of the imbalances in the numbers between groups of prognostic importance. This study underlines the need for an adequate inspection of the infra-abdominal contents at the time of hysterectomy for uterine fibroids.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1992.tb13827.x
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  • 8
    Electronic Resource
    Electronic Resource
    Is Stage I epithelial ovarian cancer overtreated both surgically and systemically? Results of a five-year cancer registry review (1992)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 99 (1992), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objective To review the incidence of Stage I epithelial ovarian carcinoma in the West Midlands region and to identify prognostic factors that have a significant effect on survival.Design A retrospective review of all Stage I ovarian cancer patients registered from 1.1.80 to 31.12.84.Setting West Midlands Regional Cancer Registry.Population 457 patients with Stage I ovarian cancer—373 with epithelial ovarian carcinoma.Main outcome measures Survival at censor date of 30.6.89.Results 28% developed recurrent disease, and the overall 50-year survival of the group was 70%. Univariate analysis of all possible prognostic factors showed that stage, adjuvant chemotherapy, histological grade and type, surgical rupture of the tumour, intact capsule histologically, clinical finding of ascites and the performance of peritoneal washings were significantly associated with survival. Adequate surgical staging as defined by FIGO was not significantly associated with survival. A multivariate analysis based on the Cox proportional hazard model identified histological grade, adjuvant chemotherapy, patient age and peritoneal washings as having independent prognostic effects. Surprisingly adjuvant chemotherapy and peritoneal washings had negative effects on survival.Conclusions Although a retrospective review has limitations, it would appear that adequate surgical staging and adjuvant chemotherapy confer no benefit in terms of survival in Stage I disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1992.tb14393.x
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  • 9
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    Peter J. Mayo, "The Morphology of Aspect in Seventeenth-Century Russian (Based on the Texts of the Smutnoe Vremja)" (Book Review) (1987)
    Cambridge : Periodicals Archive Online (PAO)
    The Modern language review. 82:2 (1987:Apr.) 532 
    Details
    ISSN: 0026-7937
    Topics: Linguistics and Literary Studies
    Notes: REVIEWS
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:0094-1987-082-02-000126
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  • 10
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    Literature from the Beginning in 1700 (1979)
    London, etc. : Periodicals Archive Online (PAO)
    The Year's work in modern language studies. 41 (1979) 1027 
    Details
    ISSN: 0084-4152
    Topics: Linguistics and Literary Studies
    Description / Table of Contents: RUSSIAN STUDIES
    Notes: SLAVONIC STUDIES
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:0015-1979-041-00-000070
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