ISSN:
1435-0130
Keywords:
Wound healing
;
Diethyl maleate
;
Tensile strength
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Diethyl maleate (DEM) which binds and thus depletes tissue glutathione levels was used to aggravate the injury and to determine its effect on incisional healing. A 5 cm dorsal midline skin incision was performed on 40 albino Wistar rats in two groups and then closed by interrupted sutures. Groups received 0.9% NaCl and DEM at a dosage of 1 mg/kg/day intraperitoneally for seven days, respectively. On postoperative days 7 and 14, histopathological assessment and tensile strengths were measured. The DEM treated group had a marked inflammation with poorly defined collagen formation and the tensile strength measurements revealed a significant decrease (p 〈0.001) on the 7t day. On the other hand, the first group showed better collagenization and a lesser degree of inflammation. However, on the 14th day, there was no noticeable histopathological difference between the two groups; but, tensile strength values of the second group were still lower (p 〈0.05). In this animal model, DEM postponed the healing process and reduced the tensile strength.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01387856
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