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  • 1
    Electronic Resource
    Electronic Resource
    Melkersson-Rosenthal Syndrome (2005)
    Oxford, UK; Malden, USA : Blackwell Publishing Ltd/Inc.
    Journal of cutaneous pathology 32 (2005), S. 0 
    Details
    ISSN: 1600-0560
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A 13 year-old boy presented with a six-month history of severe lip swelling. His past medical history was significant for eczema, multiple episodes of urticaria, and two episodes of anaphylaxis. Physical exam revealed severe cheilitis and labial angioedema. The cranial nerves were intact, and there was no evidence of a fissured tongue. A lip biopsy showed noncaseating granulomas throughout the dermis, with extension into the underlying skeletal muscle. Other features included dilated lymphatic channels, some closely approximating the granulomas, and a mild perivascular lymphoplasmacytic infiltrate. The epidermis was acanthotic with parakeratosis and focal acantholysis. Methenamine silver and acid-fast stains were negative. A laboratory work-up revealed an increased total eosinophil count, an increased serum IgE level, and a low complement C1q level. All other complement levels were normal. The patient also had an unremarkable chest x-ray and a normal angiotensin converting enzyme level. This case represents the monosymptomatic form of Melkersson-Rosenthal syndrome (MRS), also known as cheilitis granulomatosa Meischer. MRS is classically known as a triad of granulomatous cheilitis, facial nerve palsy, and fissured tongue. The onset of granulomatous cheilitis typically precedes the other symptoms, and when present alone, it is known as the monosymptomatic form of MRS.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0303-6987.2005.320br.x
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  • 2
    Electronic Resource
    Electronic Resource
    CD30-Positive Peripheral T-Cell Lymphoma (2005)
    Oxford, UK; Malden, USA : Blackwell Publishing Ltd/Inc.
    Journal of cutaneous pathology 32 (2005), S. 0 
    Details
    ISSN: 1600-0560
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A 47 year-old female presented with a five-month history of left lower extremity cellulitis which was refractory to oral antibiotics. Physical exam revealed focal erythema of the left lower extremity and left inguinal adenopathy. A left leg skin punch biopsy revealed a dense infiltrate present primarily within the deep dermis consisting of markedly atypical large cells with prominent nuclear pleomorphism and focal multinucleation. Many of the cells displayed “horseshoe shaped” or “donut shaped” nuclei, consistent with so-called hallmark cells and/or wreath cells. Scattered mitoses were also observed. Imunohistochemical stains for CD45 and vimentin were positive. Stains for cytokeratins AE1/AE3, CK7, desmin, and S-100 protein were negative. The CD45-positive population was also positive for CD3, CD30, CD45 Ro, and epithelial membrane antigen. They were negative for CD20, CD15, and CD43. A biopsy of the left inguinal lymph nodes revealed involvement by a morphologically similar neoplasm with an identical immunohistochemical staining pattern. Additionally, a CD56 and ALK-1 stain were performed on the lymph node biopsy, and both were negative. This neoplastic process represents a CD30-positive peripheral T-cell lymphoma. The differential diagnosis includes an ALK-1-negative anaplastic large cell lymphoma and a primary cutaneous CD30-positive T-cell lymphoproliferative disorder.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0303-6987.2005.320bq.x
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  • 3
    Electronic Resource
    Electronic Resource
    Critical Steps in Breast Carcinogenesis (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 698 (1993), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1993.tb17187.x
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  • 4
    Electronic Resource
    Electronic Resource
    Antibiotics and enzymes produced by the biocontrol agent Streptomyces violaceusniger YCED-9 (1998)
    Springer
    Journal of industrial microbiology and biotechnology 21 (1998), S. 81-90 
    Details
    ISSN: 1476-5535
    Keywords: Keywords: nigericin; geldanamycin; guanidylfungin A; chitinase; β-1,3-glucanase; Streptomyces violaceusniger; biocontrol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Streptomyces violaceusniger strain YCED-9 is an antifungal biocontrol agent antagonistic to many different classes of plant pathogenic fungi. We discovered that strain YCED-9 produces three antimicrobial compounds with antifungal activity. These compounds were purified and identified, and included: AFA (Anti-Fusarium Activity), a fungicidal complex of polyene-like compounds similar to guanidylfungin A and active against most fungi except oomycetes; nigericin, a fungistatic polyether; and geldanamycin, a benzoquinoid polyketide highly inhibitory of mycelial growth of Pythium and Phytophthora spp. Antimicrobial assays were developed to estimate the production of each antibiotic independently. Medium composition had differential effects on the production of each metabolite. The hydrolytic enzymes chitinase and β-1,3-glucanase are also produced under induction by colloidal chitin and laminarin, respectively. Fungal cell walls induced the production of both enzymes. A potential for biological control of diseases caused by P. infestans was also suggested by strain YCED-9’s strong in vitro antagonism towards pathogenic isolates of this fungus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/sj.jim.2900549
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