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  • 1
    Electronic Resource
    Electronic Resource
    Alcohol intoxication reduces visual sustained attention (1988)
    Springer
    Psychopharmacology 96 (1988), S. 442-446 
    Details
    ISSN: 1432-2072
    Keywords: Alcohol ; Ethanol ; Vigilance ; Sustained attention
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Effects of alcohol intoxication on visual sustained attention were studied using a vigilance task entailing detection of degraded target stimuli. Data were obtained in separate sessions under four ethanol doses, ranging from 0 (placebo) to 1.05 g/kg lean body weight, with periodic maintenance dosing of 0.12 g/kg. Intoxication lowered the overall level of detection performance, and in addition produced dose-related increases in the rate of performance decrement over time. Analysis of performance data using techniques derived from Signal Detection Theory indicated that the decrements were due specifically to alterations in perceptual sensitivity. Examination of eye movements and blinks indicated that the effects of ethanol were not mediated peripherally. Rather, alcohol appears to have deleterious effects on central processing capacity and the availability of capacity over time. The alcohol-related failure of sustained attention may contribute to increased accident risk in tasks requiring continuous performance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02180021
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Behavioral interactions of fluoxetine and other 5-hydroxytryptamine uptake inhibitors with ethanol in tests of anxiety, locomotion and exploration (1988)
    Springer
    Psychopharmacology 96 (1988), S. 528-533 
    Details
    ISSN: 1432-2072
    Keywords: Mice ; 5HT Uptake inhibitors ; Ethanol ; Locomotor activity ; Anxiety
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The 5HT uptake inhibitor fluoxetine had no effect on motor activity or directed exploration (head-dipping) in a holeboard test or in an elevated plusmaze test of anxiety. Fluoxetine (20 mg/kg) attenuated the anxiolytic effect of a 2.4 g/kg dose of ethanol in the plusmaze but failed to alter ethanol's effects on exploratory head-dipping or locomotion. This interaction did not seem directly related to fluoxetine's 5HT uptake inhibiting properties because it was not observed with other 5HT uptake inhibitors (fluvoxamine and citalopram). Desipramine, which predominantly inhibits noradrenaline uptake, also failed to show effects similar to those of fluoxetine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02180035
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    The role of orosensory stimuli from ethanol and blood-alcohol levels in producing conditioned taste aversion in the rat (1975)
    Springer
    Psychopharmacology 44 (1975), S. 267-271 
    Details
    ISSN: 1432-2072
    Keywords: Conditioned taste aversion ; Oral ingestion of ethanol ; Blood-alcohol levels ; Orosensory stimuli
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A taste-aversion paradigm was used to demonstrate that aversive consequences accompany the rapid oral ingestion of 5% (v/v) ethanol solutions. The learned taste aversion resulted from five 10-min self-administrations of alcohol mixed with an originally preferred flavor at a dosage of 1.69 g alcohol/kg body weight/day. In contrast, when the consumption of the alcohol solution was distributed throughout the day, a conditioned aversion was not obtained. This outcome was observed even though the distributed drinking animals were exposed to more orosensory stimuli and ingested more g/kg than the 10-min animals. The observation that those animals that drank their daily fluid in 10 min demonstrated higher peak blood-alcohol levels than the distributed animals supports the conclusion that a centrally mediated aversive state of inebriation must be present to produce a conditioned aversion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00428905
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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