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  • 1
    ISSN: 1432-1041
    Keywords: Key words Pantoprazole; Proton pump inhibitor drug interaction ; oral anticoagulant phenprocoumon ; pharmacodynamics ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Objective: Pantoprazole is a selective proton pump inhibitor characterized by a low potential to interact with the cytochrome P450 enzymes in man. Due to the clinical importance of an interaction with anticoagulants, this study was carried out to investigate the possible influence of pantoprazole on the pharmacodynamics and pharmacokinetics of phenprocoumon. Methods: Sixteen healthy male subjects were given individually adjusted doses of phenprocoumon to reduce prothrombin time ratio (Quick method) to about 30–40% of normal within the first 5–9 days and to maintain this level. The individual maintenance doses remained unaltered from day 9 on and were administered until day 15. Additionally, on study days 11–15, pantoprazole 40 mg was given per once daily. As a pharmacodynamic parameter, the prothrombin time ratio was determined on days 9 and 10 (reference value) and on days 14 and 15 (test value), and the ratio test/reference was evaluated according to equivalence criteria. Results: The equivalence ratio (test/reference) for prothrombin time ratio was 1.02 (90% confidence interval 0.95–1.09), thus fulfilling predetermined bioequivalence criteria (0.70–1.43). The pharmacokinetic characteristics AUC0–24h and Cmax of S(−)-and R(+)-phenprocoumon were also investigated using equivalence criteria. Equivalence ratios and confidence limits of AUC0–24h and of Cmax of S(−)-phenprocoumon (0.93, 0.87–1.00 for AUC0–24h; 0.95, 0.88–1.03 for Cmax) and of R(+)-phenprocoumon (0.89, 0.82–0.96; 0.9, 0.83–0.98) were within the accepted range of 0.8–1.25. Conclusion: Pantoprazole does not interact with the anticoagulant phenprocoumon on a pharmacodynamic or pharmacokinetic level. Concomitant treatment was well tolerated.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Archives of Biochemistry and Biophysics 35 (1952), S. 468-469 
    ISSN: 0003-9861
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 112 (1983), S. 911-918 
    ISSN: 0006-291X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 58 (1987), S. 780-783 
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: The temperature dependence of the response of piezoelectric "bimorphs'' (large-closed-square) ((large-closed-square) Registered trademark of Vernitron Corp., Bedford, OH) has been studied. This response is markedly decreased as temperature is decreased. Since the bimorphs are voltage limited, the amount of motion available is thus reduced as the temperature is lowered. This effect is important in the design specifications for the use of bimorphs at low temperatures.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 60 (1989), S. 956-958 
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: We have designed and built a sample probe that is particularly well suited for measuring the resistivity and superconducting transition temperature Tc of bulk high-Tc materials of nonuniform shape, in the temperature range 77 K〈T〈200 K. The probe uses spring-loaded indium pressure contacts and allows electrical contact to be made without altering or contaminating the sample. The probe is relatively efficient because of its short turn-around time in mounting of samples and cylcing of temperature. The resistivity and Tc of a bulk Y1Ba2Cu3−xAgxO7 sample was measured and the results compared with those from a more elaborate sample probe and Dewar system.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 79 (1996), S. 4002-4008 
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Polycrystalline samples of Ir4LaGe3Sb9, Ir4NdGe3Sb9, and Ir4SmGe3Sb9 have been made by hot isostatic pressing of powders. The lattice thermal conductivity of these filled skutterudites is markedly smaller than that of IrSb3; thus, void filling shows promise as a method for improving the thermoelectric properties of these materials. We present the lattice thermal conductivity of these filled skutterudites in an effort to quantify the impact of void filling in this structure. It is believed that the atoms "rattle'' in the voids of the structure and therefore interact with a broad spectrum of lattice phonons, reducing their mean free paths substantially below that in the "unfilled'' skutterudites. An additional phonon scattering mechanism is caused by phonon-stimulated transitions between the low-lying energy levels of the 4f electron configurations in the case of Nd3+ and Sm3+. Magnetic susceptibility and Hall-effect measurements are also presented. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 79 (1996), S. 8412-8418 
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We have measured the electrical resistivity, ρ, thermoelectric power, α, and thermal conductivity, κ, of the skutterudite material IrSb3 in a temperature range from 300 down to 4 K. It is found that the electrical resistivity and thermopower decrease monotonically as the temperature is reduced to 50–60 K. Below approximately 60 K the resistivity rises in a semiconducting manner. It appears the thermopower exhibits a large phonon drag peak at around 20 K and then falls towards zero. The thermal conductivity increases rapidly as the temperature is decreased with a maximum at around 20 K, corresponding to the peak in the thermopower. We will discuss these results and compare them to higher temperature data from G. A. Slack and V. G. Tsoukala [(IrSb3) J. Appl. Phys. 76, 1635 (1994)]. We have also measured some of the so-called "filled skutterudites,'' Ir4LaGe3Sb9, Ir4NdGe3Sb9 and Ir4SaGe3Sb9. The thermoelectric properties of these materials are considerably different than those of the unfilled sample. The thermopower is considerably lower and the resistivity is a factor of 2–4 times higher than the unfilled sample at room temperature. The thermal conductivity is markedly reduced by the filling, as much as a factor of 20 reduction for some of the systems. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 73 (1993), S. 5536-5538 
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: A theoretical model which accounts for the variations of the giant magnetoresistance, Δρ/ρ, with electron mean free path, L, interface roughness, r, and magnetic, tM, and normal layer, tN, thickness has been previously presented for sandwich films. It employs the quantum-size-effect theory of resistivity in thin films and relies on spin dependent transmission or reflection at individual layer boundaries to establish the metallic quantum-well states. This model has now been extended (i) to films where L can be different in the magnetic, LM, and nonmagnetic, LN, layers, (ii) to an electron/atom number, n, of 0.131 as well as 1.047, and (iii) to films from sandwiches to those with as many as 64 (63) magnetic (nonmagnetic) layers. The focus is on films with relatively thin tM and tN where quantum, as distinguished from semiclassical, effects should dominate. Typical results can be summarized as follows: for tM∼tN∼10 monolayers, ML, and L's∼70 ML, Δρ/ρ increases more rapidly as LM than LN, but this effect is reduced as one goes from sandwiches to superlattices; Δρ/ρ is approximately 50% in a superlattice with r=5 ML, which is an order of magnitude larger than in a superlattice with r=1 ML. In a sandwich the difference between r=5 and r=1 is closer to a factor of 5. In the sandwiches Δρ/ρ is smaller for n=0.131 than for n=1.05.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 70 (1991), S. 5819-5821 
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Temperature-dependent longitudinal and transverse magnetoresistance measurements have been carried out on a series of five Fe-Ni multilayer thin films. The samples were prepared by sputtering onto glass substrates that were nominally at room temperature and proved to be highly textured with the (111) direction perpendicular to the substrate. The multilayer wavelength ranged from 21 to 155 A(ring) with each sublayer composed of an equal number of monolayers of Fe and Ni. For the larger-wavelength films the magnetoresistance data shows a preferred direction of in-plane magnetization associated with the film growth parameters. With the field perpendicular to the plane the data shows the characteristic break at the applied magnetic field required for saturation. This saturation field is not temperature dependent and does not vary much or in any systematic manner with wavelength. Above the saturation field the magnetoresistance varies linearly with applied field with a slope, dR/dH, that varies systematically with temperature but very little with wavelength. For the smaller-wavelength samples where both the Fe and Ni are in the fcc crystal structure there is evidence in both the magnetization and dR/dH for a more complicated magnetic structure than either the long-wavelength films or bulk materials. In particular there is evidence for atomic scale magnetic anisotropy that differs from the film average.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 62 (1991), S. 1010-1014 
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: We describe a device for measuring Young's modulus Y and the piezoresistance of "whiskerlike'' samples. The device can be used in a standard vari-temp Dewar in the temperature range 1.5 K〈T〈360 K. One end of the sample is attached to a movable rod suspended by leaf springs and the other end is held fixed. Force is applied to the rod by a coaxial electromagnet acting on permanent magnets attached to the rod. Displacements are measured with a capacitive technique. We have used the device to measure Young's modulus for the charge density wave material TaS3. We also measured the Young's modulus of some Cu whiskers for comparison.
    Type of Medium: Electronic Resource
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