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  • 1
    Electronic Resource
    Electronic Resource
    A 10-year survey of inflammatory bowel diseases—drug therapy, costs and adverse reactions (2001)
    Oxford UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 15 (2001), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Drug therapy for Crohn’s disease and ulcerative colitis is based on anti-inflammatory and immunodulating drugs, nutritional support and surgical resection. Recently, new drugs have been introduced.〈section xml:id="abs1-2"〉〈title type="main"〉Aim:To report drug prescriptions, costs and adverse reactions among inflammatory bowel disease patients in Sweden between 1988 and 1997.〈section xml:id="abs1-3"〉〈title type="main"〉Methods:Drug use was calculated from the national Diagnosis and therapy survey and drug costs from prescriptions and drug sales. Adverse drug reactions were obtained from the Medical Products Agency’s National Pharmacovigilance system.〈section xml:id="abs1-4"〉〈title type="main"〉Results:The annual drug exposure for Crohn’s disease was 0.55 million daily doses per million population, mainly supplementation and aminosalicylic acids. Mesalazine and olsalazine had 61% within this group. For ulcerative colitis patients, drug exposure was 0.61 million daily doses per million per year and aminosalicylic acids fell from 70% to 65%. For inflammatory bowel disease patients, corticosteroids and nutritional supplementation were common. The annual average cost for inflammatory bowel disease drugs was 7.0 million US dollars. Anually, 32 adverse drug reactions were reported, mainly haematological reactions such as agranulocytosis and pancytopenia (60%), followed by skin reactions. Only two deaths were reported. Aminosalicylic acids were the most commonly reported compounds.〈section xml:id="abs1-5"〉〈title type="main"〉Conclusions:Drug use for inflammatory bowel disease in the pre-biologic agent era rested on aminosalicylic acid drugs and corticosteroids with stable levels, proportions and costs. The level of adverse drug reactions was low but haematological reactions support the monitoring of inflammatory bowel disease patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2036.2001.00942.x
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  • 2
    Electronic Resource
    Electronic Resource
    Allergy and cancer (2005)
    Oxford, UK : Munksgaard International Publishers
    Allergy 60 (2005), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background:  Conflicting results have provided support for two distinct and contradictory hypotheses: (i) allergy has a protective effect against cancer by enhanced immune surveillance, and (ii) allergy is associated with an increased risk of cancer by chronic immune stimulation. We therefore aimed us to perform a large epidemiological study with a defined allergic disease cohort.Methods:  During the years 1988–2000, 70 136 patients tested for total serum immunoglobulin E (IgE) and 57 815 tested with Phadiatop for diagnosing allergic disease at Karolinska University Hospital, Stockholm, Sweden, were linked with the Swedish Cancer Registry for a virtually complete follow up with regard to cancer.Findings:  The total number of observed cancers was normal in the total serum IgE-cohort; standardized incidence ratio (SIR) = 0.98 (95% CI: 0.92–1.04) and in the Phadiatop-cohort: SIR = 0.99 (0.92–1.06) independent of the level of IgE and positive or negative Phadiatop. Specific analysis was done for cancer of the lung, cervix, pancreas, lymphoma, and nonmelanoma skin cancer. None of these forms of cancer had increased risks.Interpretation:  The study does not support the hypothesis that allergy has a protective effect against cancer, nor does it support an increased risk.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1398-9995.2005.00808.x
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  • 3
    Electronic Resource
    Electronic Resource
    Risk of pancreatic and periampullar cancer following cholecystectomy (1996)
    Springer
    Digestive diseases and sciences 41 (1996), S. 387-391 
    Details
    ISSN: 1573-2568
    Keywords: cholecystectomy ; pancreatic cancer ; periampullar cancer ; epidemiology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract An increased risk of pancreatic cancer following cholecystectomy has been reported in some studies but not in others. In order to settle this question, a population-based cohort consisting of 62,615 patients who had undergone cholecystectomy was followed up for the occurrence of pancreatic and periampullar cancer up to 23 years. After excluding the first year after operation, there were 261 pancreatic cancers vs 216.8 expected [standardized incidence ratio (SIR)=1.20; 95% confidence interval (CI)=1.06–1.37]; and 11 periampullar cancers vs 7.2 expected (SIR=1.52; 95% CI=0.76–2.72). The increased risk of pancreatic cancer was most prominent up to four years after operation, but was also significantly increased 15 years or more after operation (SIR=1.35; 95% CI=1.00–1.78). We conclude that there is a modest excess risk of pancreatic and periampullar cancer following cholecystectomy, most prominent up to four years after operation, but that also exists 15 years or more after operation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02093833
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  • 4
    Electronic Resource
    Electronic Resource
    Ueber die Monofluornaphtaline (1889)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 22 (1889), S. 1846-1846 
    Details
    ISSN: 0365-9496
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.18890220229
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