ISSN:
1612-1112
Keywords:
Chemical modification of silica
;
Liquid chromatography
;
Cardiac glycosides
;
Chromatographic investigation of adsorption from solution
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Summary The chemical modification of silica surface using dichlorosilanes with methyl and phenyl groups and triethylamine as donor in the liquid phase was investigated. This modification leads to a dense coverage of the silica surface by the organic functional groups. Liquid chromatography permits the determination of the thermodinamic characteristics of intermolecular interactions of different molecules during adsorption from solutions on the modified surface of the silica. Silica gels modified with dichlorosilanes containing phenyl groups, possess high selectivity (α) and capacity (k′) for the cardiac glycosides G-strophanthin, K-strophanthoside, K-strophanthin-β and cymarin using water-alcohol mixture as the mobile phase, and the selectivity and capacity is much higher than observed on silica gels modified with methyl groups only.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02262056
Permalink