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  • 1
    Electronic Resource
    Electronic Resource
    5-HT3 receptor over-expression decreases ethanol self administration in transgenic mice (1998)
    Springer
    Psychopharmacology 140 (1998), S. 243-248 
    Details
    ISSN: 1432-2072
    Keywords: Key words 5-HT3 receptor ; Over-expression ; Transgenic animal model ; Alcohol drinking
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The 5-HT3 receptor is thought to play a role in the reward pathway and the phenomena of drug abuse by modulating dopamine release in the mesolimbic pathway. Studies involving this receptor have been hampered due to the low level of 5-HT3 receptors in the CNS. A 5-HT3 receptor over-expressing mouse was produced to study the role of this receptor in the rewarding properties of drugs of abuse. Over-expression was restricted to the forebrain by controlling gene expression with the Ca2+ calmodulin (CAM) kinase IIα promoter. No over-expression was detected in other body organs nor the cerebellum, as measured by ligand binding and Northern analysis. 5-HT3 receptor over-expressing mice drank less alcohol than non-transgenic mice in a two-bottle free choice test. Over-expression of the 5-HT3 receptor in these mice resulted in a decrease in ethanol consumption. These mice should prove useful in testing hypothesis regarding a common reward pathway for drugs of abuse and the role 5-HT3 receptors play in this pathway.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002130050763
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    5-HT3 receptor over-expression enhances ethanol sensitivity in mice (1999)
    Springer
    Psychopharmacology 144 (1999), S. 411-415 
    Details
    ISSN: 1432-2072
    Keywords: Key words 5-HT3 receptor ; Transgenic mice ; Alcohol sensitivity ; LRR ; Open field activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Ethanol sensitivity may play a role in the risk of developing alcoholism. The role of 5-HT3 receptors in sensitivity to ethanol was assessed in mice over-expressing the 5-HT3 receptor in the forebrain. Sleep time and ED50 for loss of righting reflex (LRR) were used to assess the effect of a high dose of ethanol in transgenic versus non-transgenic mice. The ED50 for ethanol-induced increase in open field activity was used to measure differences in sensitivity to low dose ethanol. The ED50 for ethanol-induced increase in activity was 41% lower in the 5-HT3 receptor over-expressing transgenic mice compared to non-transgenic mice. However, 5-HT3 receptor over-expressing mice did not differ from control mice in ethanol metabolism, ED50 for LRR, and ethanol sleep time. Over-expression of 5-HT3 receptors in mouse forebrain results in an enhanced sensitivity to the stimulating effects of a low dose of ethanol without altering ethanol sedating effects or ethanol metabolism. These data suggest that 5-HT3 receptors modulate low dose ethanol sensitivity and may explain why, in previous studies, these mice consume less ethanol.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002130051025
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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