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  • 1
    Electronic Resource
    Electronic Resource
    Decreased deformability of erythrocytes in hyperglycaemic non-inbred ob/ob mice (1986)
    Springer
    Diabetologia 29 (1986), S. 661-666 
    Details
    ISSN: 1432-0428
    Keywords: Diabetic mice ; hyperglycaemia ; hyperinnsulinaemia ; ob/ob mice ; erythrocyte deformability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The deformability of erythrocytes from non-inbred ob/ob mice and lean controls was analyzed by filtration through Nuclepore polycarbonate under constant pressure. At the age of 1–2 months there was no difference in erythrocyte filtrability between the two types of mice, whereas from 3 months the ob/ob mouse erythrocytes exhibited a markedly decreased deformability. The filtrability of erythrocytes was sensitive to osmotic pressure (NaCl or glucose). However, the difference between normal and ob/ob mouse of erythroyctes was not due to acute osmotic effects of the hyperglycaemia in the ob/ob mice. When filtration was performed in the same glucose concentration as that recorded in the blood of the erythrocyte-donor animal, the difference in filtrability between adult normal and ob/ob mice remained large and significant (p 〈 0.01). Moreover, the most pronounced hyperglycaemia occurred in young ob/ob mice with normal erythrocyte filtrability. It is suggested that non-inbred ob/ob mice are a useful model for studying the damaging influence of diabetes on erythrocyte deformability.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00869267
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Insulin-driven erythropoiesis may underlie impairment of erythrocyte deformability in hyperinsulinaemic, hyperglycaemic ob/ob-mice (1990)
    Springer
    Diabetologia 33 (1990), S. 127-130 
    Details
    ISSN: 1432-0428
    Keywords: Erythrocyte ; erythropoiesis ; insulin ; erythrocyte deformability ; erythrocyte shape ; ob/ob-mice
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The circulating erythrocytes in hyperglycaemic and hyperinsulinaemic obese (ob/ob) mice are enlarged with a decreased erythrocyte filtrability and an abnormally low resistance to osmotic stress. These changes probably reflect aberrations of erythropoiesis, as evidenced by enhanced staining for iron in the bone marrow, reticulocytosis, and increased erythrocyte volume fraction. Mature erythrocytes, reticulocytes, and late-phase basophilic erythroblasts were found to have larger diameters than their counterparts in control mice while myelopoiesis appeared to be unaffected. The average erythrocyte also displayed an increased cell volume and a decreased haemoglobin concentration. It is suggested that the stimulation of the erythroid cell line in ob/ob-mice might be a consequence of the hereditary hyperinsulinaemia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00404037
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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