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  • 1
    Electronic Resource
    Electronic Resource
    Spontaneous object recognition and object location memory in rats: the effects of lesions in the cingulate cortices, the medial prefrontal cortex, the cingulum bundle and the fornix (1997)
    Springer
    Experimental brain research 113 (1997), S. 509-519 
    Details
    ISSN: 1432-1106
    Keywords: Key words Fornix ; Cingulate cortex ; Prefrontal cortex ; Cingulum bundle ; Hippocampus ; Object recognition ; Object location ; Memory ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The first experiment assessed the effects of neurotoxic lesions in either the anterior cingulate cortex (ACc) or the retrosplenial cortex (RSc) on a test of object recognition. Neither lesion affected performance on this task, which takes advantage of the rat’s normal preference to spend more time investigating novel rather than familiar stimuli. In response to this negative result, a second experiment assessed the effects of much more extensive cingulate lesions (Cg) on both object recognition and object location memory. The latter task also used a preference measure, but in this case it concerned preference for a novel location. For comparison purposes this second study included groups of rats with lesions in closely allied regions: the fornix (Fx), the cingulum bundle (CB) and the medial prefrontal cortex (Pfc). Comparisons with sham-operated control rats showed that none of the four groups (Cg, Fx, CB, Pfc) was impaired on the object recognition task, adding further weight to the view that these structures are not necessary for assessing stimulus familiarity. The Fx and Cg groups were, however, impaired on the object location task, suggesting that these regions are necessary for remembering other attributes of a stimulus (spatial location).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00005603
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    High sensitivity of brain octopamine levels to stress (1986)
    Springer
    Psychopharmacology 88 (1986), S. 305-309 
    Details
    ISSN: 1432-2072
    Keywords: Octopamine ; Catecholamines ; Rat ; Stress ; Conditioned suppression
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Rats were submitted to unsignalled and uncontrolled electrical shocks. When re-exposed to the same situation but not shocked, 24 h later, their locomotor activity was significantly reduced compared to that of controls. This conditioned suppression was associated with a significant decrease in p-octopamine (OA) in brain stem and hypothalamus. Shocks delivered just before brain fixation produced an even larger decrease in cerebral OA. Heart levels of OA were not affected. Cerebral and peripheral levels of dopamine and noradrenaline were not significantly or reliably affected. These results, as those of previous experiments, suggest that octopamine is involved in emotional, neurovegetative responses to stress.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00180829
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Effect of combined or separate administration of piracetam and choline on learning and memory in the rat (1987)
    Springer
    Psychopharmacology 92 (1987), S. 58-67 
    Details
    ISSN: 1432-2072
    Keywords: Piracetam ; Choline ; Piracetam + choline ; Delayed alternation ; Two-way avoidance ; Object recognition ; 5-HT ; CAT ; Choline uptake ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Different groups of rats received combined or separate administration of different doses of piracetam (P1:100, P2:200, and P4:400 mg/kg) and choline (C1:100 and C2:200 mg/kg). Compared to control treatment, C1 significantly improved performance in a delayed alternation (DA) task, while P1, P2, P4 or P1C1 had no effect. Moreover, rats receiving P2C1 and P4C1 were significantly inferior in acquiring DA to rats receiving the vehicle or separate administration of P1, P2 or C1. The different treatments with combined or separate administration of P and C had no effect on spontaneous locomotor activity and two-way avoidance conditioning. In a recognition-task only groups C1 and P4 were able to discriminate between familiar and new objects. The combined or separate administration of P1 and C1 on NA, DA, DOPAC, 5-HT, 5-HIAA levels, CAT activity and choline uptake were measured in frontal cortex and hippocampus: the only significant effect was a 5-HT increase in the hippocampus of rats treated with C1.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00215480
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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