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  • 1
    Electronic Resource
    Electronic Resource
    Effect of mitomycin C, verapamil, and hyperthermia on human gastric adenocarcinoma (1994)
    Springer
    Cancer chemotherapy and pharmacology 34 (1994), S. 257-260 
    Details
    ISSN: 1432-0843
    Keywords: Mitomycin C ; Verapamil ; Hyperthermia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The purpose of this study was to assess the efficacy of verapamil (20 μM) and hyperthermia (42°C) as modifiers of mitomycin C (MMC), used at different concentrations, in inhibiting the growth of human gastric adenocarcinoma (AGS) cells. Combined verapamil and hyperthermia treatment resulted in a significant decrease in cell count by 72.2% as compared with the control value. Verapamil drastically enhanced the growth-inhibitory activity of MMC at high concentration against AGS cells by 67.5% and had no effect at intermediate and low concentrations. Hyperthermia did not enhance the effect of MMC on AGS cells. The modalities analyzed in this study require further investigation and may have potential for in vivo studies on gastric cancer therapy in the near future.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00685086
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of mitomycin C, verapamil, and hyperthermia on human gastric adenocarcinoma (1994)
    Springer
    Cancer chemotherapy and pharmacology 34 (1994), S. 257-260 
    Details
    ISSN: 1432-0843
    Keywords: Key words: Mitomycin C – Verapamil – Hyperthermia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. The purpose of this study was to assess the efficacy of verapamil (20 μM) and hyperthermia (42°C) as modifiers of mitomycin C (MMC), used at different concentrations, in inhibiting the growth of human gastric adenocarcinoma (AGS) cells. Combined verapamil and hyperthermia treatment resulted in a significant decrease in cell count by 72.2% as compared with the control value. Verapamil drastically enhanced the growth-inhibitory activity of MMC at high concentration against AGS cells by 67.5% and had no effect at intermediate and low concentrations. Hyperthermia did not enhance the effect of MMC on AGS cells. The modalities analyzed in this study require further investigation and may have potential for in vivo studies on gastric cancer therapy in the near future.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002800050137
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    The effect of 1,25-dihydroxyvitamin D3 on the growth of soft-tissue sarcoma cells as mediated by the vitamin D receptor (1996)
    Springer
    Annals of surgical oncology 3 (1996), S. 144-149 
    Details
    ISSN: 1534-4681
    Keywords: 1,25-dihydroxyvitamin D3 ; Soft-tissue sarcoma ; Vitamin D receptor ; Growth
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: Soft-tissue sarcomas, malignant neoplasms originating from mesenchymal tissue, are rare but highly aggressive tumors. Present modes of therapy are associated with high rates of recurrence. 1,25-Dihydroxyvitamin D3, the active metabolite of vitamin D, serves as a potent antiproliferative agent in human cancer cells. Methods: In this study, six soft-tissue sarcoma cell lines were analyzed for vitamin D receptor (VDR) expression, which was then correlated with the degree of growth inhibition in response to 1,25-dihydroxyvitamin D3. These cell lines included rhabdomyosarcoma (HS729, A204), fibrosarcoma (HS913t). synovial sarcoma (SW982), liposarcoma (SW872), and leiomyosarcoma (SKLMS-1). The level of VDR messenger RNA (mRNA) expression was determined using a ribonuclease protection assay, and functional receptor content was determined by using a ligand-binding assay. Growth studies, including [3H]thymidine up-take and growth curves, were performed on two of the six cell lines that expressed the highest and lowest receptor levels. Results: Ribonuclease protection and ligand-binding assays demonstrated variable levels of VDR, with HS729 showing high expression and A204 showing no expression. In HS729, [3H]thymidine uptake was significantly decreased at 10−7 M (33%) and 10−6 M (40%) 1,25-dihydroxyvitamin D3. Growth curve studies showed significant growth inhibition of 55% at 10−6 M. A204 cells showed no growth inhibition upon treatment with 1,25-dihydroxyvitamin D3. Conclusion: This study demonstrates the existence of VDR in soft-tissue sarcoma cells and suggests a correlation between the level of VDR in cells and the degree of growth inhibition caused by 1,25-dihydroxyvitamin D3 which may potentially serve as an alternative form of therapy for soft-tissue sarcomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02305793
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Primary non-Hodgkin's lymphoma of the stomach: Three radical modalities of treatment in 75 patients (1996)
    Springer
    Annals of surgical oncology 3 (1996), S. 277-284 
    Details
    ISSN: 1534-4681
    Keywords: Gastric lymphoma ; Surgery ; Chemotherapy ; Radiation therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: Non-Hodgkin's lymphoma (NHL) remains a rare form of gastric malignancy, with a rising incidence. Approaches to treatment vary from surgery alone to conservative management. Methods: To determine the optimal scheme of treatment, a randomized clinical trial was undertaken. Seventy-five patients were randomized into three groups: A—surgery alone (25), B—surgery followed by chemotherapy (29), and C—radiation therapy followed by surgery and chemotherapy (21). Forty-nine patients had stage IE and 26 had stage IIE disease. Chemotherapy (COP and COPP) consisted of 6 courses during a 1-year period, with the courses being 6 weeks apart. Results: Subtotal gastrectomy was performed in 26 patients. Forty-nine patients underwent total gastrectomy. Postoperative complications occurred in 6 (8%) patients: 3 (12%) in group A, 2 (6.9%) in group B, and 1 (4.7%) in group C. Postoperative mortality occurred in 2 (8%) patients in group A (2.7% of all patients). An increase in hospital admissions number per year and decrease of mean age of patients with NHL of the stomach after the Chernobyl accident on April 26, 1986 was noted. Conclusions: Improved survival in gastric NHL was achieved by a combination of preoperative radiation with surgery and postoperative chemotherapy, presumptively through the management of local and systemic disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02306283
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Laparoscopic cholecystectomy (1993)
    Springer
    Digestive diseases and sciences 38 (1993), S. 2212-2219 
    Details
    ISSN: 1573-2568
    Keywords: laparoscopic cholecystectomy ; ultrasound ; postoperative
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Seventeen consecutive patients undergoing elective laparoscopic cholecystectomy (LC) were serially evaluated with transabdominal ultrasound before, one day after, and six days after LC to document what, if any, changes occur in the surgical bed and surrounding parenchyma. The most common postoperative finding was focal sonolucency in the hepatic parenchyma adjacent to the gallbladder fossa in six (35%) of 17 patients. Five patients (29%) had postoperative fluid collections in the gallbladder fossa; in four of these five, it was technically difficult to dissect the gallbladder from the liver at the time of original surgery. In one patient the fluid resolved by the sixth postoperative day. It persisted in the remaining four. Two patients had transient ductal dilation and one had pneumobilia. Shadowing and ring-down artifact was identified in 12 patients due to surgical clips in the triangle of Calot. Because gallbladder fossa fluid may persist up to six days after uncomplicated laparoscopic cholecystectomy, caution should be used before attaching significance to isolated imaging findings. Clinical judgement remains the best means of selecting which patients need additional evaluation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01299898
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  • 6
    Electronic Resource
    Electronic Resource
    Vitamin D receptors in breast cancer cells (1994)
    Springer
    Breast cancer research and treatment 31 (1994), S. 191-202 
    Details
    ISSN: 1573-7217
    Keywords: cholecalciferol ; differentiation ; hormones ; receptors ; steroids
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1,25-(OH)2-Vitamin D3, the active metabolite of vitamin D, is a secosteroid hormone with known differentiating activity in leukemic cells. Studies have demonstrated the presence of vitamin D receptors (VDR) in a wide range of tissues and cell types. Antiproliferative activity of 1,25-(OH)2-vitamin D3 has been documented in osteosarcoma, melanoma, colon carcinoma, and breast carcinoma cells. This study was designed to analyze vitamin D receptor level in breast cancer cells as a marker of differentiation and as a predictor of growth inhibition by 1,25-(OH)2-vitamin D3. VDR messenger RNA was found to be present in relatively high levels in well-differentiated cells and in low levels in poorly differentiated cells. All cell lines had detectable VDR mRNA. Radiolabeled ligand binding assay showed a similar pattern. MCF-7 and T47D cells, which express VDR at moderate levels, showed significant growth inhibition by 10−9 M 1,25-(OH)2-vitamin D3 (p 〈 0.05). MDA-MB-231 cells, which have very low levels of VDR, demonstrated no growth inhibition by 1,25-(OH)2-vitamin D3 at concentrations up to 10−6 M. Based on these results it can be stated that VDR expression is lost with de-differentiation and that receptor is essential for the antiproliferative response to 1,25-(OH)2-vitamin D3.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00666153
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