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  • 1
    Electronic Resource
    Electronic Resource
    Kinetics of autoxidation of cobalt(II) cyclidene dioxygen carriers (1993)
    s.l. : American Chemical Society
    Inorganic chemistry 32 (1993), S. 3826-3835 
    Details
    ISSN: 1520-510X
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ic00070a011
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  • 2
    Electronic Resource
    Electronic Resource
    Linear to bent geometry changes in the gas- and solution-phase photochemistry of tricarbonylnitrosylcobalt (1981)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 103 (1981), S. 2635-2640 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja00400a026
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  • 3
    Electronic Resource
    Electronic Resource
    Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23 (2000)
    [s.l.] : Nature America Inc.
    Nature genetics 26 (2000), S. 345-348 
    Details
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Proper serum phosphate concentrations are maintained by a complex and poorly understood process. Identification of genes responsible for inherited disorders involving disturbances in phosphate homeostasis may provide insight into the pathways that regulate phosphate balance. Several hereditary ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/81664
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  • 4
    Electronic Resource
    Electronic Resource
    Toward the development of a potent, nonsedating, oral analgesic (1978)
    Springer
    Psychopharmacology 60 (1978), S. 25-28 
    Details
    ISSN: 1432-2072
    Keywords: Experimental pain ; Analgesics ; Anileridine ; Amphetamine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The separate and combined analgesic effects of 10 mg of oral amphetamine sulfate and 25 mg of oral anileridine dihydrochloride were studied in 24 healthy, adult, male volunteers. Tolerance of progressively increasing pain produced by the Submaximum Effort Tourniquet Technique was tested four times in each subject: after amphetamine, after anileridine, after the combination, and after a matching placebo. Treatments were administered double blind and in counterbalanced order. Elapsed time to report of slight, moderately distressing, very distressing, and unbearable pain was recorded on each trial. The four oral treatments differed significantly for very distressing and for unbearable pain. At each of the three upper pain levels, the mean tolerance times for anileridine and amphetamine were similar; each was longer than placebo but shorter than the combination; and the effect of the combination was approximately the sum of the effects of the two components.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00429174
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  • 5
    Electronic Resource
    Electronic Resource
    Some effects of morphine and amphetamine on intellectual functions and mood (1964)
    Springer
    Psychopharmacology 6 (1964), S. 49-56 
    Details
    ISSN: 1432-2072
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Four groups of 15 undergraduate students received either 10 mg of d-amphetamine sulfate, 16 mg of morphine sulfate, a mixture of 16 mg of morphine sulfate and 10 mg of d-amphetamine sulfate, or a lactose placebo under double blind conditions. These subjects were given, both before and after the administration of the drugs, a series of tests utilizing the Guilford structure of intellect model, the Nowlis and Nowlis mood adjective check list, and the McClelland Need Achievement Scale. It was shown that certain tests were differentially effected by the drugs. Of particular interest was an enhancement by morphine of all tests which were based upon a logical judgment and selection of an answer among a limited number of alternatives. D-amphetamine was found to enhance the performance on scales different from those most enhanced by morphine. It was found that d-amphetamine enhanced the need to achieve and elevated the sense of activation of the subjects. These results were discussed in terms of possible theoretical consequences.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00710914
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  • 6
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    Autonomic effects on estimates of time: evidence for a physiological correlate of temporal experience (1962)
    Provincetown, Mass., etc. : Periodicals Archive Online (PAO)
    Journal of Psychology. 53 (1962) 183 
    Details
    ISSN: 0022-3980
    Topics: Psychology
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:1140-1962-053-00-000016
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  • 7
    Electronic Resource
    Electronic Resource
    Dose-response effects of secobarbital on human memory (1969)
    Springer
    Psychopharmacology 14 (1969), S. 46-61 
    Details
    ISSN: 1432-2072
    Keywords: Barbiturates ; Intoxication ; Memory
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The fundamental purpose of this experiment was to obtain empiric, replicatable, dose-response data from human subjects on the psychological effects of a common psychoactive drug. Six normal humans were first trained for six sessions on a series of tasks involving different aspects of memory and attention. Their individual sensitivity to secobarbital was also determined. After training, they were tested at zero and three levels of drug on a doubleblind basis. The drug levels for a given subject were selected so that the highest level was just under that which would make the subject untestable. The four point dose-response curves were replicated three times for each subject. Some of the tasks performed by the subjects were affected by the drug in the expected manner as related to dose. Some tasks were unaffected by the drug. In no case were there drug effects which did not follow a regular dose-response curve. In all cases the dose-response curves for an individual subject were replicable. The data from the experiment were interpreted as evidence for an effort stress effect inherent in some tasks. When the demand load of the tests was great, even very high doses of secobarbital had no effect. When the demand load of a task was lower, a dose related drug action was obtained. Some questions were raised by the data on the generality of the Mirsky-Kornetsky hypothesis as to the differential effects of barbiturates on the CPT and the DSST at all dose ranges. Finally, additional evidence was added to the position that a common effect of intoxicating chemicals is to produce a less differentiated, i.e., simpler, mental structure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00401534
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  • 8
    Electronic Resource
    Electronic Resource
    A new technique for the investigation of some analgesic drugs on a reflexive behavior in the rat (1961)
    Springer
    Psychopharmacology 2 (1961), S. 318-325 
    Details
    ISSN: 1432-2072
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The analgetic action of a series of analgesic and psychotropic agents was tested in a situation in which variable intensities of electric shock to a rat's feet were used to elicit two distinguishable reflexive responses: a “flinching” response at low shock values, and a “jumping” response at higher shock values, By using a modified method of limits, reliable threshold for the two responses were obtained. Chlorpromazine, perphenazine, morphine, codeine, nalorphine and acetylsalicylate were found to raise the threshold to “jump”, but had little or no effect on the threshold to “flinch”. PIH, JB 835, iproniazid, reserpine, tetrabenazine, and amphetamine were found to have no effect on either the “jump” or the “flinch” thresholds. A combination of amphetamine and codeine was found to produce a synergistic potentiation. A combination of morphine and nalorphine was found to produce an antagonism. The results were discussed in terms of Beecher's hypothesis that the analgetic action of drugs is due to a diminution of the emotional components of an animal's reaction to pain and in terms of the relationship of brain amine change to analgetic action.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00404119
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  • 9
    Electronic Resource
    Electronic Resource
    A comparison of the analgetic potency of some analgesics as measured by the “flinch-jump” procedure (1962)
    Springer
    Psychopharmacology 3 (1962), S. 51-54 
    Details
    ISSN: 1432-2072
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of various doses of morphine, dl-methadone, nalorphine, codeine, meperidine and saline on the “flinch-jump” thresholds of rats were measured by a procedure described previously. While none of the drugs influenced the “flinch” threshold, the group slopes of elevation of “jump” thresholds were significant for all drugs studied. In order of potency as revealed by this method, nalorphine ranked with morphine and methadone, while codeine and meperidine were less potent, suggesting that the procedure may be useful as a screening test for analgesic drugs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00413106
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  • 10
    Electronic Resource
    Electronic Resource
    The effect of some centrally acting drugs on disjunctive reaction time (1962)
    Springer
    Psychopharmacology 3 (1962), S. 124-127 
    Details
    ISSN: 1432-2072
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Callaway and Stone have proposed that drugs which arouse or depress the electroencephalographic response should differentially affect the expectancy of stimuli which occur with different frequencies. The disjunctive reaction times to stimuli with different probabilities of occurrence were tested for subjects under the effect of chloropromazine, d-amphetamine, atropine, and sucrose. The data demonstrated that subject's RT is a function of the probabilities of the stimuli, that chloropromazine increases RT and that amphetamine decreases RT. There was no evidence to support the hypothesis of a differential drug effect on the “probabilistic coding” of stimuli with different probabilities of occurrence.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00408340
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