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  • 1
    Electronic Resource
    Electronic Resource
    The Future of Labour Relations in the Public Service (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Labour 5 (1991), S. 0 
    Details
    ISSN: 1467-9914
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Economics
    Notes: Abstract. During the last decade, labour relations in the public service have been subject to pressures for change, less direct, given their protected character, than in the private sector, but not less strong.The main factors of change are (only) in part common to those operating in private sector labour relations: economic constraints and budgetary restrictions, coupled with a general reaction toward the ‘public’ in general have put pressure on employment whose costs represent the major part of public expenditures; the need for greater productivity and efficiency has been increasing in order to reduce labour costs and (possibly) meet the growing demand for (social) services; technological innovations (office automation. computerization and the like) are spreading; the impact of the international competition has begun to be felt not only indirectly via constraints on the state budgets but directly in those sectors of public services which can be somehow ‘transportable’ across borders and hence exposed to foreign initiatives (public works, TLC, to some extent health services.All these factors are emphasized by the European unification process which has already introduced limits in the monetary and financial autonomy of the member states.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1467-9914.1991.tb00032.x
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  • 2
    Electronic Resource
    Electronic Resource
    α-thalassemia among Pediatric Hemoglobin S Homozygotes (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 565 (1989), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1989.tb24196.x
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  • 3
    Electronic Resource
    Electronic Resource
    Hemorheologic Parameters in Children with Homozygous Sickle Cell Anemia Receiving Chronic Red Cell Transfusions for Large Cerebral Vessel Vasculopathy (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 565 (1989), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1989.tb24223.x
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  • 4
    Electronic Resource
    Electronic Resource
    The Acute Phase Response in the Rodent (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 557 (1989), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1989.tb24000.x
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  • 5
    Electronic Resource
    Electronic Resource
    Anomaly in the γ chain heterogeneity of the newborn (1977)
    [s.l.] : Nature Publishing Group
    Nature 265 (1977), S. 63-65 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Fig. 1 Distribution of glycine residues of gCB-3 from the cord bloods of black and Caucasian newborns from different areas. Open columns denote data from newborns without haemoglobinopathy, and black columns denote data from HbS- and/or HbC-containing samples, a, Burke County blacks; b, Caucasians; ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/265063a0
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  • 6
    Electronic Resource
    Electronic Resource
    Light adaptation in cone vision involves switching between receptor and post-receptor sites (2007)
    [s.l.] : Nature Publishing Group
    Nature 449 (2007), S. 603-606 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] We see over an enormous range of mean light levels, greater than the range of output signals retinal neurons can produce. Even highlights and shadows within a single visual scene can differ ∼10,000-fold in intensity—exceeding the range of distinct neural signals by a factor of ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nature06150
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  • 7
    Electronic Resource
    Electronic Resource
    Different ζ globin gene deletions among Black Americans (1986)
    Springer
    Human genetics 〈Berlin〉 73 (1986), S. 221-224 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Four types of chromosomes with a deletion between the human embryonic ζ and ψζ globin genes were identified among 2.8% of 321 Black Americans from Georgia. Two deletions of approximately 11 kb which differed by about 300 bp occurred on chromosomes with or without a polymorphic Xba I site 5′ to the ζ globin gene [(X+) or (X-)]. The deletions are identifiable in Xba I digests of genomic DNA using an α or a ζ globin gene probe which yield fragments of 23 kb from (X+)−ζ*αα chromosomes or 27 kb from (X−)−ζ*αα chromosomes. Digestion with other enzymes and probing with both α and ζ probes gave fragments typical of the two ζ globin gene deletions previously identified in Polynesians. Among Black Americans, these ζ globin gene deletions have been found in combination with α globin gene deletions in trans but not in cis. Homozygotes have not been found. Hematologic data on carriers of the ζ globin gene deletions in association with Hb AS, SS, and SC suggest that these deletions have no effect on the function of the adult α globin genes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00401231
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  • 8
    Electronic Resource
    Electronic Resource
    Detection and quantitation of the fetal hemoglobin variant Hb F-Malta-I in adults (1977)
    Springer
    Biochemical genetics 15 (1977), S. 915-923 
    Details
    ISSN: 1573-4927
    Keywords: radioimmunoassay ; hemoglobin F variants ; hemoglobinopathies ; γ chain loci
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract A variant of fetal hemoglobin (Hb F-Malta-I) has been detected and quantitated in adult blood with a sensitive radioimmunoassay employing monospecific anti-sera. The concentration of Hb F-Malta-I was 0.002–0.05%, with an average value of 0.011%. The ratio of Hb F-Malta-I/Hb F in adults was about 4.8%, compared to a ratio of about 27% in the newborn. Since the F-Malta-I variant is a product of a mutated Gγ locus, which is one of the nonallelic structural genes directing the γ chain synthesis, its presence in blood of adults shows that the synthesis of this gene is not completely suppressed after birth, as was previously suggested.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00483988
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  • 9
    Electronic Resource
    Electronic Resource
    α-Thalassemia and the production of different α chain variants in heterozygotes (1981)
    Springer
    Biochemical genetics 19 (1981), S. 487-498 
    Details
    ISSN: 1573-4927
    Keywords: Hb α chain variants ; α-thalassemia ; Hb synthesis ; Hb genetics ; posttranslational control
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract The production of five α chain variants (Hb G-Georgia, Hb St. Luke's, Hb Lloyd, Hb Montgomery, and Hb G-Philadelphia) in heterozygotes was evaluated through hematological observations, hemoglobin quantification, and biosynthetic studies. All heterozygotes for Hb St. Luke's and Hb Lloyd and most heterozygotes with Hb G-Georgia and Hb Montgomery had normal hematology and average σα/β values of about 1.1. They were assigned a normal genotype (ααG/αα), although the proportions of Hb St. Luke's and Hb G-Georgia were low (10 to 13%) and those of Hb Lloyd and Hb Montgomery twice as high (20%). Data from short-term incubations confirmed this genotype for some of these heterozygotes. Isolated Hb St. Luke's and Hb G-Georgia gave low αG/β values (0.2 and 0.3) indicating that these Hb variants were defective at the level of Hb assembly. Isolated Hb Montgomery and Hb G-Philadelphia, however, gave higher αG/β values of 0.6 and 0.8, respectively. A second type of variability existed among Hb G-Georgia (20 vs. 13%), Hb Montgomery (28 vs. 20%), and Hb G-Philadelphia (47 vs. 34%) heterozygotes, in whom the levels of Hb G differed. The occurrence of higher levels of these three α chain heterozygosities was associated with hematological or biosynthetic evidence of a mild or moderate α chain deficiency due to an α-thalassemia-2 heterozygosity (ααG/α0α or α0αG/αα) or a homozygosity (α0αG/α0α), respectively.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00484621
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  • 10
    Electronic Resource
    Electronic Resource
    Organization of α-chain genes among Hb G-Philadelphia heterozygotes in association with Hb S, β-thalassemia, and α-thalassemia-2 (1982)
    Springer
    Biochemical genetics 20 (1982), S. 689-701 
    Details
    ISSN: 1573-4927
    Keywords: Hb α-chain genes ; molecular hybridization ; Hb G-Philadelphia ; α-thalassemia-2
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract The percentages of the α-chain variant Hb G-Philadelphia (Hb G) or α2 68 Asn→Lysβ2 were evaluated in 84 adult and 18 newborn heterozygotes. These included members of three families who were studied in more detail by nucleic acid hybridization techniques. The adult heterozygotes fell in two categories, one with a higher proportion of Hb G [46.5±1.0% (SD), N=21] and another with lower values (33.9±3.4%, N=63). Among the newborn heterozygotes, two babies fell in the category with the higher proportion of Hb G while 16 babies gave values between 25 and 34%. Studies of α-chain gene organization on the parents of one neonate with a Hb G level of 27% at birth and 37% at 8 months excluded the presence of chromosomes with triplicated α-chain genes which could lead to the α0αG/ααα genotype. Rather, these studies on five Hb G heterozygotes from three families confirmed the linkage between Hb G and a specific type of α-thalassemia-2 associated with the presence of a 16-kbp Bgl II fragment which most probably carries the αG locus since it has been found in 19 Hb G heterozygotes studied to date. The presence of an α-thal-2 heterozygosity and three α-chain genes (α0αG/αα) was confirmed among Hb G heterozygotes with lower proportions of this variant. It is likely that the even lower values found in some newborn could arise through defective assembly of αG-γ dimers. The presence of an α-thal-2 homozygosity and two active α-chain genes, one on each chromosome (α0αG/α0α), was confirmed among heterozygotes with the higher proportion of Hb G. One of each of these categories was present in each of the three families investigated. This type of variability in the number of active α-chain genes due to a heterozygosity or a homozygosity for α-thalassemia-2 explains the trimodality of Hb S percentages among heterozygotes and the atypical hematological or biosynthetic features among patients with β-thalassemia and sickle-cell syndromes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00483966
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