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  • 1
    Electronic Resource
    Electronic Resource
    Direct mutation analysis as the preferred method for carrier diagnosis in families with isolated cases of haemophilia B (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Haemophilia 2 (1996), S. 0 
    Details
    ISSN: 1365-2516
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary. Approximately one-third of haemophilia B cases are described as isolated due to their occurrence in families with no prior history of the disorder. In this report, two families with isolated haemophilia B were studied by the standard method of restriction fragment length polymorphism (RFLP) analysis coupled with factor IX activity and antigen levels with the aim of achieving carrier diagnoses. The limitations of using this approach in the determination of carrier status were highlighted by diagnostic problems arising in both families. The problems included difficulty in interpreting bioassay results, homozygosity for the RFLP marker in a key family member and the possibility of germline mosaicism. Unequivocal carrier diagnosis in the two families was ultimately achieved by direct mutation analysis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2516.1996.tb00136.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Mechanism of an action of an antibacterial murine lymphokine (1975)
    [s.l.] : Nature Publishing Group
    Nature 254 (1975), S. 459-460 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The antibacterial activity was assayed on a diaminopimelic-acid (DAP)-dependent auxotrophic mutant of Escherichia coli, cultured in DAP-free supportive medium. DAP is utilised in the synthesis of the pentapeptide normally involved in cross-linking of polymeric macromolecules in cell walls and as a ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/254459a0
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Detection and prevalence of serotypes of feline syncytial spumaviruses (1985)
    Springer
    Archives of virology 83 (1985), S. 53-63 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Three serotypes of feline syncytial virus (FSV) were detected by neutralisation tests: 906, a serotype of low prevalence and 702 and 951 which were serotypes of higher prevalence, between which a minor one-way antigenic difference was detected. Serum antibody in naturally-infected cats in some cases neutralised 951 but not 702 or 906 which suggested that 951 could be considered as a major distinct serotype. An increase in prevalence of antibody to FSV in cats over a 5 year period from 1977–1981 was detected by neutralisation, agar gel immunodiffusion, and fluorescent antibody techniques. Over the 5 year period the prevalence of antibody to the 951 serotype increased and the overall increase in prevalence of antibody to FSV during this period appeared to relate to dissemination of the 951 serotype.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01310964
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    Paper (German National Licenses)
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