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  • 1
    ISSN: 1433-8726
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Thirteen patients with midline pathology of the bladder or prostate and two normal volunteers were examined by Magnetic Resonance Imaging (MRI) using a variety of pulse sequences. The MRI results were compared with computed tomography (CT) and transrectal or transurethral ultrasound (US). This study demonstrates that MRI is capable of visualizing pathology of the bladder and prostate at least as well as CT and US. However, MRI seems to be more advantageous in identifying lesions of tumors in the roof and base of the bladder because of flexible imaging planes. MRI is also very promising in the staging of pelvic malignancies because of excellent contrast between tumor and nearby important anatomical structures. This indicates that MRI might become the modality of choice in urological disease of the bladder and prostate.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1433-8726
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The purpose of this prospective study was to compare the accuracy of magnetic resonance imaging (MRI) and computed tomography (CT) in the diagnosis and staging of renal masses. MRI was performed with an 0.5 T superconducting MR-scanner using conventional T1- and T2-weighted spin-echo pulse sequences. The results of MRI and CT were compared in 31 patients with a renal mass. In the diagnosis of benign tumors, similar information was obtained by MRI and CT. Regarding malignant tumors, one transitional cell carcinoma, imaged by CT, was not shown by MRI. CT appeared to be slightly more accurate in the determination of perinephric extension of renal cell carcinoma (stage I vs stage II). Similar results were obtained in stage III and stage IV tumors. The main diagnostic limitations which may lead to inaccurate staging of renal cell carcinoma are encountered in MRI as well as CT. They are: the assessment of tumor extension into the intrarenal vein, the differentiation between lymphadenopathy due to reactive hyperplasia and metastatic involvement and the differentiation between tumor extension into adjacent organs and adhesions without tumor spread outside the renal capsule. It is concluded that CT remains the method of choice in the diagnosis and staging of renal masses as long as no substantial improvements in MRI performance have been achieved.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-2161
    Keywords: Bone tumour ; Bone neoplasm ; Ewing's sarcoma ; MR imaging ; Chemotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Magnetic resonance (MR) imaging was performed in 26 patients with Ewing's sarcoma of bone preceding and following neoadjuvant chemotherapy, to assess tumour response non-invasively prior to surgery. T1- and T2-weighted spin echo images were obtained. Changes including intra- and extramedullary signal intensities, tumour demarcation, tumour volume and the appearance of residual extramedullary tumour were compared with histopathology of the resected specimens. Reduction of tumour volume was significantly higher in good responders. Other single parameters did not correlate with histologic tumour response. However, when several MR parameters summarized in a classification system were combined, a positive correlation with histopathologic response was found. A limited decrease of tumour volume (〈25%) and/or residual soft tissue mass following chemotherapy correlated with a poor response. An inhomogeneous, well-defined cuff of abnormal tissue encircling the bone and/or radiological disappearance of the soft tissue tumour component following chemotherapy correlated with good response. Twenty-three out of 26 patients were correctly classified by MR as good or poor responders. Minimal residual disease (〈10% of the entire tumour volume), observed histologically, could not be identified with MR imaging. Tumour volume reduction and residual extramedullary tumour, rather than changes of signal intensity, are major features for evaluating the response to chemotherapy in Ewing's sarcoma.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei einer Patientin mit systemischem Lupus erythematodes wurde röntgenologisch eine Wirbelosteomyelitis diagnostiziert. In Material, das durch Punktur des dritten Lendenwirbelkörpers gewonnen wurde, ließ sich kulturell wiederholtCandida albicans nachweisen. Sechs Monate vorher war die Patientin mit Kortikosteroiden behandelt und parenteral ernährt worden. Zu dieser Zeit wurden aus dem Blut und von der Spitze des entfernten Subclavia-Katheters Hefen kultiviert. Nachdem eine Wirbelosteomyelitis durchCandida diagnostiziert worden war, wurde die Patientin sieben Monate lang mit Ketoconazol behandelt. Entsprechend den klinischen und röntgenologischen Befunden kam es zu einem eindrucksvollen Heilungsverlauf. Zwölf Monate nach Beendigung der Ketoconazolbehandlung — zum Zeitpunkt der Manuskripterstellung — waren bei der Patientin keine Zeichen für einen Rückfall festzustellen.
    Notes: Summary Candida vertebral osteomyelitis was diagnosed in a patient with systemic lupus erythematodes following X-ray evidence of osteomyelitis and the repeated culturing ofCandida albicans from material obtained by needle biopsies from the third lumbar vertebra. The patient had been on glucocorticosteroids and parenteral nutrition six months previously. At that time, a yeast was cultured from the blood and the tip of the subclavian catheter which had been removed. After candida vertebral osteomyelitis was diagnosed, she was treated with ketoconazole for seven months. Recovery was impressive, as judged by the clinical and radiographic findings. At the time of writing this paper — 12 months after the withdrawal of ketoconazole — the patient showed no signs of recurrence.
    Type of Medium: Electronic Resource
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