ISSN:
0170-2041
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Description / Table of Contents:
Constituents of Euphorbiaceae, Vl. - Three New 4-Deoxyphorbol Triesters from Euphorbia biglandulosa Desf.The new 4-deoxyphorbol triesters 13,20-O-diacetyl-12-O-(Z,E)-2,4-octadienoyl-4-deoxyphorbol (1), 20- O-acetyl-12-O-(Z,E)2,4-octadienoyl-13-O-propionyl-4-deoxyphorbol (2) and 20-O-acetyl-13-O-isobutyryl-12-O-(Z,E)-2,4-octadienoyl-4-deoxyphorbol (3) were isolated from the lipophilic phase of the latex sap of Euphorbia biglandulosa Desf. Their structure and that of the compounds 1a, 1b,2a and 3a formed on hydrolysis have been established by IR-, 1H-NMR- and mass spectroscopy. - The natural compounds have an irritating action on the skin of mice, a toxic on fishes and inhibit the oxidative phosphorylation of isolated heart mitochondria.
Notes:
Aus der lipophilen Phase des Milchsaftes von Euphorbia biglandulosa Desf. wurden 13,20-O-Diacetyl-12-O-(Z,E)-2,4-octadienoyl-4-desoxyphorbol (1), 20-O-Acetyl-12-O-(Z,E)-2,4-octa-dienoyl-13-O-propionyl-4-desoxyphorbol (2) und 20-O-Acetyl-13-O-isobutyryl-12-O-(Z,E)-2,4-octadienoyl-4-desoxyphorbol (3) isoliert. Die Strukturen dieser Verbindungen und ihrer Hydrolysederivate 1a, 1b, 2a,3a wurden durch IR-, 1H-NMR- und Massen-Spektroskopie belegt. -Die Substanzen 1-3 wirken als Fischgifte; sie sind hautätzend und hemmen die oxidative Phosphorylierung isolierter Herzmitochondrien.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jlac.197919790806
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