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  • 1
    Electronic Resource
    Electronic Resource
    Alkynes and poly(ethylene glycol) derivatives as nucleophiles and catalysts in substitution reactions of 1-chloroanthraquinones (1991)
    s.l. : American Chemical Society
    The @journal of organic chemistry 56 (1991), S. 7059-7065 
    Details
    ISSN: 1520-6904
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jo00025a021
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  • 2
    Electronic Resource
    Electronic Resource
    Malaria Thermoregulation in a parasite's life cycle (2002)
    [s.l.] : Nature Publishing Group
    Nature 418 (2002), S. 742-742 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The life cycle of the malaria parasite Plasmodium falciparum goes through three developmental stages (schizogony, gametogony and sporogony), each of which presents different environmental constraints that must be met by an adaptive response in the parasite. Here we show that thermoregulation, ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/418742a
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  • 3
    Electronic Resource
    Electronic Resource
    Activation of Melatonin Receptor Sites Retarded the Depletion of Norepinephrine Following Inhibition of Synthesis in the C3H/HeN Mouse Hypothalamus (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 55 (1990), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: The aim of the present study was to determine the effect of activation of melatonin receptor sites on the activity of noradrenergic neurons in the C3H/HeN mouse brain. Changes in noradrenergic activity were assessed by measuring norepinephrine (NE) levels in the hypothalamus, frontal cortex, and hippocampus following inhibition of NE synthesis with α-methyl-p-tyrosine (α-MpT) (300 mg/kg, i.p., 2 h). 6 Chloromelatonin (1–30 mg/kg, i.p.) significantly retarded the α-MpT-induced decrease in NE levels in the hypothalamus, but not in hippocampus and frontal cortex. This effect was observed at 30 min and 60 min after 6-chloromelatonin administration and was dose dependent. At noon, when the levels of endogenous melatonin are low, the melatonin receptor antagonist luzindole (30 mg/kg, i.p., 30 min) did not affect the depletion of NE by α-MpT; however, it (1–30 mg/ kg) completely antagonized the 6-chloromelatonin-induced reduction of NE depletion elicited by α-MpT in hypothalamus. These results suggest that activation of melatonin receptor sites in brain of C3H/HeN mouse retarded the depletion of NE elicited by α-MpT. At midnight, when the levels of melatonin are high, luzindole (30 mg/kg) significantly accelerated the depletion of NE by α-MpT in hypothalamus, but not in frontal cortex or hippocampus, suggesting activation of melatonin receptor sites by endogenous melatonin. We conclude that activation of melatonin receptor sites in C3H/HeN mouse brain by endogenous melatonin inhibits the activity of noradrenergic neurons innervating the hypothalamus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1990.tb08823.x
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  • 4
    Electronic Resource
    Electronic Resource
    An observational study of six chromospherically active binaries
    Amsterdam : Elsevier
    Chinese Astronomy and Astrophysics 18 (1994), S. 191-197 
    Details
    ISSN: 0275-1062
    Keywords: binariesuchromospherically active binariesu Hα emission
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0275-1062(94)90101-5
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  • 5
    Electronic Resource
    Electronic Resource
    Critical behaviour of the double-well potentials in glasses
    Amsterdam : Elsevier
    Solid State Communications 60 (1986), S. 373-376 
    Details
    ISSN: 0038-1098
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0038-1098(86)90753-2
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  • 6
    Electronic Resource
    Electronic Resource
    Effects of Melatonin Agonists and Antagonists on Reproduction and Body Weight in the Siberian Hamster (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of pineal research 9 (1990), S. 0 
    Details
    ISSN: 1600-079X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: This study examined whether melatonin-induced inhibition of testicular weight and body weight in vivo could be antagonized by luzindole, a competitive melatonin receptor antagonist, or methysergide, a competitive serotonin receptor antagonist. Adult male Siberian hamsters were exposed to a long photoperiod (16L:8D) and given daily injections of drugs 3 h before lights off for 7 weeks. Hamsters treated with melatonin (0.375 mg/kg) exhibited testicular regression and loss of body weight. These effects were also marked in hamsters treated concommitantly with melatonin (0.375 mg/kg) and luzindole (10 mg/kg). In other studies, chronic injections of luzindole (30 mg/kg) to juvenile hamster failed to antagonize testicular regression induced by either melatonin injections or exposure to a short day photoperiod (12L: 12D). In contrast, concommitant injections of methysergide (6.25 mg/kg) and melatonin attenuated testicular regression and loss of body weight. When administered alone, neither luzindole nor methysergide affected testicular weight or body weight, whereas chronic injections of 5-methyoxyluzindole (10 mg/kg) mimicked the inhibitory effects of melatonin. 5-Methoxyluzindole inhibits 2-[125I]-iodomelatonin binding to median eminence/pars tuberalis membranes with an affinity similar to that of melatonin. Luzindole shows lower affinity for the inhibition of 2-[125I]-iodomelatonin binding than melatonin, which may explain why luzindole is not an effective melatonin receptor antagonist when administered in vivo. Methysergide, which has a very low affinity for inhibition of 2-[125I]-iodomelatonin binding, probably inhibits the effects of melatonin by blocking serotonergic neurotransmission.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-079X.1990.tb00898.x
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  • 7
    Electronic Resource
    Electronic Resource
    Effects of pretreatment with androgen or thyrold hormone on androgen-induced proliferation of granular convoluted tubular cells in mouse submandibular glands (1993)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 236 (1993), S. 679-684 
    Details
    ISSN: 0003-276X
    Keywords: Submandibular gland ; Granular convoluted tubular cell ; Thyroid hormone ; Androgen ; Mouse ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The effects of pretreatment with androgen or thyroid hormone on androgen-induced proliferation of granular convoluted tubular cells (GCT cells) in the submandibular glands of ovariectomized female BALB/c or C57BL/6 mice were investigated. The proliferation of GCT cells was estimated by their labeling index. Daily injections of 5α-dihydrotestosterone (DHT) (100 μg/mouse/day) caused a transient increase in the labeling index of GCT cells of ovariectomized 60-day-old BALB/c mice during the first four injections, but injections of thyroxine (T4) (15 μg/mouse/day) did not. On the other hand, both DHT and T4 increased the esteroprotease activity, a marker of the differentiation of GCT cells, time dependently. Injections of DHT into ovariectomized 102-day-old BALB/c mice also caused a transient increase in the labeling index of GCT cells. However, pretreatment of ovariectomized 60-day-old BALB/c mice with DHT for 4 or 14 days completely abolished the DHT-induced increase in the labeling index of 102-day-old mice, and pretreatment with T4 for 14 days reduced this increase. Pretreatment with DHT or T4 for 14 days did not affect the DHT-induced increase in esteroprotease activity. Pretreatment of ovariectomized 60-day-old C57BL/6 mice with DHT for 14 days also completely abolished the DHT-induced increase in the labeling index of GCT cells at the age of 102 days, but pretreatment with T4 for 14 days did not affect the increase. These results suggest that the proliferation of mouse GCT cells induced by androgen results in a complete abolition of their proliferative response to androgen, and that the effect of thyroid hormone on the proliferative response of GCT cells to androgen may differ in different strains of mice. © 1993 Wiley-Liss, Inc.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1092360412
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  • 8
    Electronic Resource
    Electronic Resource
    Non-homogeneous radiation and outflow boundary conditions simulating incoming acoustic and vorticity waves for exterior computational aeroacoustics problems (1998)
    Chichester : Wiley-Blackwell
    International Journal for Numerical Methods in Fluids 26 (1998), S. 1107-1123 
    Details
    ISSN: 0271-2091
    Keywords: computational aeroacoustics ; radiation boundary conditions ; scattering of sound or vorticity waves ; high-order finite difference solutions ; Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: A set of non-homogeneous radiation and outflow boundary conditions which automatically generate prescribed incoming acoustic or vorticity waves and, at the same time, are almost transparent to outgoing sound waves produced internally in a finite computation domain is proposed. This type of boundary condition is needed for the numerical solution of many exterior aeroacoustics problems. In computational aeroacoustics, the computation scheme must be as non-dispersive and non-dissipative as possible. It must also support waves with wave speeds which are nearly the same as those of the original linearized Euler equations. To meet these requirements, a high-order/large-stencil scheme is often necessary. The proposed non-homogeneous radiation and outflow boundary conditions are designed primarily for use in conjunction with such high-order/large-stencil finite difference schemes. © 1998 John Wiley & Sons, Ltd.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
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