ISSN:
0942-0940
Keywords:
Ischaemia
;
cerebral function
;
cerebral blood flow
;
haemodilution
;
hypercapnia
;
intracerebral steal
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The direct cortical response (DCR) and associated local cerebral blood flow was recorded from the primate cerebral cortex during a period of focal ischaemia induced by middle cerebral artery occlusion (MCAO). The DCR was lost when local blood flow fell below 20ml/ 100g/min but began to recover as collateral flow increased. Hypercapnia demonstrated a loss of local vascular reactivity following MCAO, but isovolaemic haemodilution still proved effective in increasing blood flow to these areas. The reduction in blood oxygen content induced by haemodilution did not impair cerebral function but the reduction in whole blood viscosity did exacerbate cerebral susceptibility to hypercapnia-induced intra-cerebral steal.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01808768
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