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  • 1
    ISSN: 1432-1076
    Keywords: Chronic granulomatous disease ; Recombinant human granulocyte-macrophage colony stimulating factor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Variant X-linked chronic granulomatous disease (CGD) is characterised by a decreased but still measurable respiratory burst and cytochrome b content of phagocytes resulting in a clinically milder form of the disease. We examined the in vivo effect of recombinant human granulocyte-macrophage colony stimulating factor (rh-GM-CSF) on the neutrophil functions of a patient treated for liver abscess. The number of white blood cells was markedly increased at the highest dose of GM-CSF injected (30 μg/kg per day). This was mainly due to a large increase in eosinophils and to a lesser extent in neutrophils. No change in the deficient neutrophil respiratory burst nitroblue tetrazolium (NBT)-reduction, superoxide (O 2 − )-production and cytochrome b content was observed during 6 weeks of therapy with increasing doses of GM-CSF. No significant clinical improvement of the liver abscess was observed during treatment with GM-CSF.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Cancer Genetics and Cytogenetics 38 (1989), S. 167 
    ISSN: 0165-4608
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Monatsschrift Kinderheilkunde 147 (1999), S. 725-732 
    ISSN: 1433-0474
    Keywords: Schlüsselwörter Schädel-Hirn-Trauma ; Schädelfraktur ; Hirnverletzung ; Hirndruck ; Hirnödem ; Key words Head injury ; Brain damage ; Intracranial pressure ; Brain swelling/edema ; Skull fracture
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Background: Analysis of the impact of head fractures, intracranial hemorrhages, brain edema, and prognostic risk factors on long-term outcome in children with severe head injury. Methods: Retrospective analysis of prognostik risk factors of 150 children after severe head injury (GCCS≤8) by univariate and multivariate analysis. Results: 150 of 227 children (median age 6.6 years), sustained a severe head injury. 92 of them (61.3%) had traffic related injuries. 65 children (43.4%) had skull fractures, 87 patients (58.0%) an intracranial hemorrhage, and 79 patients (52.7%) a diffuse brain swelling/edema within 72 h after trauma. 33 deaths (22%) were related in most cases to secondary brain swelling/edema. Children with an initial GCSS〈5 had a probability of 18% of survival. 59 children (39.3%) had severe neurological impairments at the time of discharge. Therapeutic modalities (hyperventilation, mannitol-infusions, dexamethasone-therapy) showed no significant positive nor negative effects on survival. Conclusions: The major risks for death or neurological impairment after severe head injury in children are primary areflexia and the development of secondary brain swelling/edema, indicated by a low GCSS (3-5).
    Notes: Zusammenfassung Fragestellung: Untersucht wurden der Einfluß von Schädelfrakturen, intrakranialen Blutungen, Hirnödem und therapeutischen Maßnahmen auf das Langzeitüberleben von Kindern mit schwerem Schädel-Hirn-Trauma (SHT). Methode: Retrospektiv wurden prognostische Risikofaktoren bei 223 Kindern mit Schädel-Hirn-Trauma mittels univariater und multivariater Regressionsanalyse ausgewertet. Ergebnisse: Von den 227 Kindern (medianes Alter 6,6 Jahre) hatten 150 ein schweres SHT [GCSS≤8 (Glasgow-Coma-Scale-Score)]. Von diesen 150 Kindern mit schwerem SHT hatten 92 (61,3%) Verkehrsunfälle erlitten. 65 Kinder (43,3%) hatten Schädelfrakturen, 87 Patienten (58,0%) intrakraniale Blutungen, und 79 Kinder (52,7%) entwickelten eine Hirnschwellung bzw. ein Hirnödem innerhalb von 72 h nach dem Trauma. Die meisten der 33 Todesfälle (22%) waren Folge der Hirnschwellung bzw. des sekundären Hirnödems. Kinder mit einem GCSS〈5 hatten eine Überlebenswahrscheinlichkeit von 18%. 59 Kinder (39,3%) wurden mit schweren neurologischen Handicaps nach Hause entlassen. Schlußfolgerungen: Das Hauptrisiko für Tod oder neurologisches Handicap nach schwerem Schädel-Hirn-Trauma bei Kindern waren primäre Areflexie und die Entwicklung einer sekundären Hirnschwellung bzw. eines Hirnödems. Der Glasgow-Coma-Scale-Score war ein guter prognostischer Indikator.
    Type of Medium: Electronic Resource
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