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  • 1
    Electronic Resource
    Electronic Resource
    Gene expression profiles in psoriasis: analysis of impact of body site location and clinical severity (2005)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 152 (2005), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background  Psoriasis is characterized by symmetry of plaques and modulation of multiple genes within those plaques.Objectives  We compared gene expression profiles of plaques of psoriasis at different anatomical sites for both symmetrical and asymmetrical disease to ascertain whether the same genes were expressed.Methods  Gene expression profiles were analysed in biopsies from lesional and uninvolved skin from two groups of patients with either predominantly symmetrical or truncal plaques of psoriasis vulgaris, and from normal skin of healthy volunteers. Genomic analyses were performed using cDNA array and kinetically monitored reverse transcriptase-initiated polymerase chain reaction (kRT-PCR) approaches. A cluster of genes upregulated in involved psoriasis skin as compared with normal skin was identified using each of these two technologies.Results  Clustering of patients based on their gene expression profile did not reveal any correlation with family history of psoriasis, age at onset or association of psoriasis with arthritis. There was no difference in gene expression profile between the type (symmetrical vs. truncal) or location (left vs. right side of body) of psoriatic plaques. Gene expression profiles of involved psoriatic skin analysed by kRT-PCR analysis did correlate with both global (Psoriasis Area and Severity Index) and local (erythema, desquamation and plaque elevation) clinical severity.Conclusions  These results indicate that it may be feasible to analyse the molecular effects of pharmacological agents on psoriatic skin in ‘minizone’ protocols, that the obtained data can be correlated with clinical severity and that plaques of psoriasis in the same individual express the same genes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.2005.06384.x
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  • 2
    Electronic Resource
    Electronic Resource
    Influence of insufficiency and excess of thyroid hormones in the rabbit body upon the activity of a nonspecific inhibitor of hyaluronidase (1966)
    Springer
    Bulletin of experimental biology and medicine 61 (1966), S. 521-523 
    Details
    ISSN: 1573-8221
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The object of study was the influence of thyroid gland hormones on the activity of nonspecific antihyaluronidase in rabbits. For this purpose, a hypothyroid state of thyrotoxicossi of a variable degree was induced in the animals. It was found that there was an inverse relationship between the antihyaluronidase activity of the blood serum and the concentration of protein-bound iodine in the blood plasma. With a decrease in protein-bound iodine, the activity of hyaluronidase grew, and with an increase in its level the activity of the inhibitor lessened. Apparently, thyroid hormones take part in the regulation of mucopolysaccharide metabolism through a change in the activity of the nonspecific inhibitor of hyaluronidase.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01892443
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Determination of plasma bupropion and its relationship to therapeutic effect (1984)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 11 (1984), S. 629-632 
    Details
    ISSN: 0306-042X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: An analytical method to determine the concentration of bupropion in human plasma has been developed using a deuterium-labeled analog as internal standard and selected ion monitoring applied to an extract of plasma samples taken as part of a clinical trial of this antidepressant. In all, 15 depressed outpatients were randomly assigned to bupropion in a double-blind study which included weekly evaluation of their clinical condition. A good correlation was found between the results obtained by this assay and by a radioimmunoassay technique currently in use. While no simple correlation between plasma concentration and therapeutic improvement was noted, the majority of subjects showed mild to marked amelioration of symptoms and those having mean concentrations above 35 ng ml-1 had significant improvement in their test scores. Interpretation of the mass spectra of both the labeled and unlabeled drug revealed an apparent violation of the ‘even-electron rule’.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200111207
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    Paper (German National Licenses)
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