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  • 1
    Digitale Medien
    Digitale Medien
    Changes in muscle free carnitine and acetylcarnitine with increasing work intensity in the Thoroughbred horse (1990)
    Springer
    European journal of applied physiology 60 (1990), S. 81-85 
    Details
    ISSN: 1439-6327
    Schlagwort(e): Carnitine ; Acetylcarnitine ; Exercise ; Muscle ; Horse
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Treadmill exercise in Thoroughbred horses of 2 min duration and increasing intensity resulted in increased formation and accumulation of acetylcarnitine in the working middle gluteal muscle. At high work intensities a plateau in acetylcarnitine formation was reached corresponding to approximately 70% of the total carnitine pool (approx. 30 mmol · kg−1 dry muscle). Formation of acetylcarnitine was mirrored by an equal fall in the free carnitine content, which stabilised, at the highest work intensities, at around 8 mmol · kg− dry muscle. Acetylcarnitine and carnitine reached their point of maximum change at a work intensity just below that resulting in the rapid production and accumulation of lactate and glycerol 3-phosphate. It is possible that the formation of acetylcarnitine is important in the regulation of the intramitochondrial acetyl CoA/CoA ratio; equally these changes may represent a blocking mechanism aimed at preventing the transfer of unwanted free fatty acids (as acylcarnitines) into the mitochondria at work intensities where they could contribute little to energy production.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00846025
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Formation of acetylcarnitine in muscle of horse during high intensity exercise (1987)
    Springer
    European journal of applied physiology 56 (1987), S. 639-642 
    Details
    ISSN: 1439-6327
    Schlagwort(e): Carnitine ; Acetylcarnitine ; Pyruvate metabolism ; Muscle ; Horse ; Exercise
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary To study the changes in carnitine in muscle with sprint exercise, two Thoroughbred horses performed two treadmill exercise tests. Biopsies of the middle gluteal were taken before, after exercise and after 12 min recovery. Resting mean muscle total carnitine content was 29.5 mmol · kg−1 dry muscle (d. m.). Approximately 88% was free carnitine, 7% acetylcarnitine and acylcarnitine was estimated at 5%. Exercise did not affect total carnitine, but resulted in a marked fall in free carnitine and almost equivalent rise in acetylcarnitine. The results are consistent with a role for carnitine in the regulation of the acetyl-CoA/CoA ratio during sprint exercise in the Thoroughbred horse by buffering excess production of acetyl units.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00424803
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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